Prof. Chao Tong , Journal of Biological Chemistry: Sec22 Regulates ER Morphology but not Autophagy and Is Required for Eye Development in Drosophila

文章出处: 作者: 发布时间: 2015-04-03 访问次数: 60

 

On February 10, 2015, Dr. Chao Tong’s group published a research article online entitled "Sec22 Regulates ER Morphology but not Autophagy and Is Required for Eye Development in Drosophila " in the Journal of Biological Chemistry. 

 

The endoplasmic reticulum (ER) is a highly dynamic organelle that plays a critical role in many cellular processes. Abnormal ER morphology is associated with some human diseases, although little is known regarding how ER morphology is regulated. Using a forward genetic screen to identify genes that regulated ER morphology in Drosophila, Dr. Tong’s group identified a mutant of Sec22. The orthologs of Sec22 in yeast, plants, and humans are required for ER to Golgi trafficking. However, the physiological function of Sec22 has not been previously investigated in animal development. In this study, Dr. Tong’s group found  malfunction of Sec22 and its binding partners Syx5, Eyc results in ER expansion and defects in fly eye development. This work showed that Sec22 regulates ER morphology through regulating ER-Golgi trafficking but not autophagy. The study proposed that appropriate trafficking between the ER and Golgi is required for maintaining ER morphology, which indicates that ER morphology changes under the disease conditions might due to the defects of ER-Golgi trafficking.