张晓坤教授

文章出处: 作者: 发布时间: 2015-03-04 访问次数: 553

 

张晓坤,Ph.D.

教授、博士生导师。教育部“长江学者”特聘教授,中组部“千人计划”获得者。厦门大学药学院院长。

 电话:0592-2181851  传真:0592-2181879

Emailxkzhang@xmu.edu.cn

地址:厦门市翔安区厦门大学药学院  361102

 

教育及工作经历

 

1982年毕业于厦门大学生物学系,

1989年获美国佛蒙特州大学生物化学博士学位,

1989年起在美国加州圣地亚哥桑福德-伯纳姆医学研究所(Sanford-Burnham Institute for Medical Research)从事核激素受体的基础研究和药物开发应用工作,历任博士后、助理教授、副教授,2006年起任教授。

2006年作为五位主要发起人之一,组建厦门大学生物医学研究院,

200610月起担任厦门大学生物医学研究院院长。

2007年受聘为教育部第八批生物医学学科“长江学者”讲座教授。

2008年成为中组部“海外高层次人才引进计划”(即“千人计划”)首批入选者,国家特聘专家,并于2010年起按“千人计划”合同约定,全职回国工作。

201012月起担任在原厦门大学生物医学研究院、医学院药学系等的基础上,新整合成立的厦门大学药学院院长。

 

研究成果

 

张晓坤教授长期从事核激素受体的前沿研究,主要集中于维生素A、视黄醇类化合物和衍生物的抗癌作用,以及凋亡信号转导通路的研究。在《自然》、《科学》及《细胞》等国际核心期刊发表了100余篇具有重要创见的核激素受体研究论文;在美国及中国获得十几项专利;在国内外承担多项重大科研课题,是国家基金重大研究计划、教育部创新团队负责人;为美国NIH等科学基金委员会评审专家,担任多个国际一流杂志资深审稿人,如CellNatureNature Cell BiologyScienceMol. Cell. Biol.Cancer Research等。

 

张晓坤教授是核激素受体RXR同源二聚体及异源二聚体作用机制的发现者,根据其发现的新型分子作用机制,张晓坤教授及其团队在1999年成功开发了世界上第一个针对核受体RXR靶点的抗癌专利药Targretin®Targretin®被《自然药物开发》及药物界同行认为是从199320019年间国际上22个被美国FDA批准的最有创新突破的靶点药物之一。近年来张晓坤教授及团队率先在国际上报道了核激素受体的非基因型作用机制及针对该机制的靶点药物开发新模式,并发现了多个针对该模式的具有开发潜力的药物先导小分子化合物及小肽,为寻找高效低毒的靶向核激素受体的药物及制定个性化治疗策略探索了一条新的途径。

 

 

图为根据张晓坤教授的发明专利,由美国Ligand 制药公司开发的抗癌新药Targretin® /Bexarotene,已被FDA批准广泛应用于癌症病人的治疗。

 

发表的论文

 

1.    Zhang, X-k., Huang, D.P., Chiu, D.K., and Chiu, J.F.  The expression of oncogenes in human developing liver and hepatomas.  Biochem. Biophys. Res. Comm. 142: 932-938. 1987.

2.    Zhang, X-k., Wang, Z., Lee, A., Huang, D.P., and Chiu, J.F.  Differential expression of cellular oncogenes during rat liver development.  Cancer Lett. 41: 147-155. 1988.

3.    Li, P.M., Zhong, J.L., Chen, R.Q., Zhang, X-k., Ho, K.L., Chiu, J.F., and Huang, D.P.  Zhi-mu saponin inhibits alpha-fetoprotein gene expression in developing rat liver.  Int. J. Biochem. 21: 15-22. 1989.

4.    Graupner, G., Wills, K.N., Tzukerman, M., Zhang, X-k., and Pfahl, M.  Dual regulatory role for thyroid-hormone receptors allows control of retinoic acid receptor activity.  Nature (London) 340: 653-656. 1989.

5.    Zhang, X-k., Huang, D.P., Qiu, D.K., and Chiu, J.F.  The expression of c-myc and c-N-ras in human cirrhotic livers, hepatocellular carcinomas and liver tissue surrounding the tumors.  Oncogene 5: 909-914. 1990.

6.    Hoffmann, B., Lehmann, J.M., Zhang, X-k., Hermann, T., Graupner, G., and Pfahl, M.  A retinoic acid receptor-specific element controls the retinoic acid receptor-? promoter.  Mol. Endocrinol. 4: 1727-1736. 1990.

7.    Tzukerman, M., Zhang, X-k., Hermann, T., Wills, K.N., Graupner, G., and Pfahl, M.  The human estrogen receptor has transcriptional activator and repressor functions in the absence of ligand.  New Biol. 2: 613-620. 1990.

8.    Pfahl, M., Tzukerman, M., Zhang, X-k., Lehmann, J.M., Hermann, T., Wills, K.N., and Graupner, G.  Nuclear retinoic acid receptors: cloning, analysis, and function.  Methods Enzymol. 189: 256-270. 1990.

9.    Zhang, X-k., Zucker, M.I., Huang, D.P., Lin, T-S., Prusoff, W.H., and Chiu, J.F.  Alteration of cellular oncogene expression in L1210 cells by a nitrosoureaalalog of thymidine.  Cancer Comm. 3: 119-126. 1991.

10.  Zhang, X-k., Dong, J.M., and Chiu, J.F.  Regulation of ?-fetoprotein gene expression by antagonism between AP-1 and the glucocorticoid receptor at their overlapping binding site.  J. Biol. Chem. 266: 8248-8254. 1991.

11.  Graupner, G., Zhang, X-k., Tzukerman, M., Wills, K.N., Hermann, T., and Pfahl, M.  Thyroid hormone receptors repress estrogen receptor activation of a TRE.  Mol. Endocrinol. 5: 365-372. 1991.

12.  Hermann, T., Zhang, X-k., Tzukerman, M., Wills, K.N., Graupner, G., and Pfahl, M.  Regulatory functions of a non-ligand-binding thyroid hormone receptor isoform.  Cell Regul. 2: 565-574. 1991.

13.  Pfahl, M., Zhang, X-k., Lehmann, J.M., Husmann, M., Graupner, G., and Hoffmann, B.  Molecular mechanisms of retinoic acid action.  In G. Morriss-Kay (ed.), Retinoids in normal development and teratogenesis.  Oxford University Press, Oxford. p. 51-64. 1992.

14.  Zhang, X-k., Wills, K.N., Graupner, G., Tzukerman, M., Hermann, T., and Pfahl, M.  Ligand-binding domain of thyroid hormone receptors modulates DNA binding and determines their bifunctional roles.  New Biol. 3: 169-181. 1991.

15.  Wills, K.N., Zhang, X-k., and Pfahl, M.  Coordinate expression of functionally distinct thyroid hormone receptor ? isoforms during neonatal brain development.  Mol. Endocrinol. 5: 1109-1119. 1991.

16.  Tzukerman, M., Zhang, X-k., and Pfahl, M.  Inhibition of estrogen receptor activity by the tumor promoter 12-O-tetradeconylphorbol-13-acetate: a molecular analysis.  Mol. Endocrinol. 5: 1983-1992. 1991.

17.  Yang-Yen, H-F*., Zhang, X-k.*, Graupner, G., Tzukerman, M., Sakamoto, B., Karin, M, and Pfahl, M.  Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation.  New. Biol. 3: 1206-1219. 1991.  *Equal contribution.

18.  Zhang, X-k., Tran, P.B., and Pfahl, M.  DNA binding and dimerization determinants for thyroid hormone receptor ? and its interaction with a nuclear protein.  Mol. Endocrinol. 5: 1909-1920. 1991.

19.  Zhang, X-k., Wills, K.N., Husmann, M., Hermann, T., and Pfahl, M.  Novel pathway for thyroid hormone receptor action through interaction with junand fos oncogene activities.  Mol. Cell. Biol. 11: 6016-6025. 1991.

20.  Zhang, X-k., Hoffmann, B., Tran, P., Graupner, G., and Pfahl, M.  Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors.  Nature (London) 355: 441-446. 1992.

21.  Lehmann, J.M., Zhang, X-k., and Pfahl, M.  RAR?2 expression is regulated through a retinoic acid response element embedded in SP1 sites.  Mol. Cell. Biol. 12: 2976-2985. 1992.

22.  Hermann, T., Hoffmann, B., Zhang, X-k., Tran, P., and Pfahl, M.  Heterodimeric receptor complexes determine 3,5,3'-triiodothyronine and retinoid signaling specificities.  Mol. Endocrinol. 6: 1153-1162. 1992.

23.  Zhang, X-k., Egan, J.O., Huang, D-p., Sun, Z.L., Chien, V.K., and Chiu, J.F.  Hepatitis B virus DNA integration and expression of an erbB-like gene in human hepatocellular carcinoma.  Biochem. Biophys. Res. Commun. 188: 344-351. 1992.

24.  Tran, P., Zhang, X-k., Salbert, G., Hermann, T., Lehmann, J.M., and Pfahl, M.  COUP orphan receptors are negative regulators of retinoic acid response pathways.  Mol. Cell. Biol. 12: 4666-4676. 1992.

25.  Zhang, X-k., Lehmann, J.M., Hoffmann, B., Dawson, M., Cameron, J., Graupner, G., Hermann, T., Tran, P., and Pfahl, M.  Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid.  Nature (London) 358: 587-591. 1992.

26.  Hermann, T.,  Hoffmann, B., Piedrafita, F.J., Zhang, X-k., and Pfahl, M.  V-erb A requires auxiliary proteins for dominant negative activity.  Oncogene. 8: 55-65. 1993.

27.  Zhang, X-k. and Pfahl, M.  Regulation of retinoid and thyroid hormone action through homodimeric and heterodimeric receptors.  Trends Endocrinol. Metab. 4: 156-162. 1993.

28.  Lehmann, J.M., Zhang, X-k., Graupner, G., Lee, M.O., Hermann, T., Hoffmann, B., and Pfahl, M.  Formation of retinoid X receptor homodimers leads to repression of T3 response: hormonal cross talk by ligand-induced squelching.  Mol. Cell. Biol. 13: 7698-7707. 1993.

29.  Zhang, X-k. and Pfahl, M.  Hetero- and homodimeric receptors in thyroid hormone and vitamin A action.  Receptor. 3: 183-191. 1993.

30.  Zhang, X-k. and Pfahl, M.  Molecular mechanisms of action for vitamin-A derived hormones in receptor-mediated biological processes.  Implications for Evaluating Carcinogens. (ed. T.J. Slaga). Wiley-Liss Press. 1993.

31.  Zhang, X-k., Salbert, G., Lee, M-O., and Pfahl, M.  Mutations that alter ligand-induced switches and dimerization activities in the retinoid X receptor.  Mol. Cell. Biol. 14: 4311-4323. 1994.

32.  Pfahl, M., Apfel, R., Bendik, I., Fanjul, A., Graupner, G., Lee, M-O., La-Vista, N., Lu, X-P, Piedrafita, J., Ortiz-Caseda, A., Salbert, G., and Zhang, X-k.  Nuclear retinoid receptors and their mechanism of action.  Vitamins and hormones. (ed. Gerald Litwac). Vol. 49, pp. 327-382. 1994.

33.  Lee, M-O., Hobbs, P.D., Zhang, X-k., Dawson, M.I., and Pfahl, M.  A synthetic retinoid antagonist inhibits the human immunodeficiency virus type 1 promoter.  Proc. Nat. Acad. Sci. 91: 5632-5636. 1994

34.  Zhang, X-k., Liu, Y., Lee, M-O., and Pfahl, M.  A specific defect in the retinoic acid response associated with human lung cancer cell lines.  Cancer Res. 54: 5663-5669. 1994.

35.  Zhang, X-k.  Molecular mechanisms of action for vitamin A-derived hormones.  Prog. Clin. Biol. Res. 387: 59-71. 1994.

36.  Lee, M-O., Liu, Y., and Zhang, X-k.A retinoic acid response element that overlaps an estrogen response element mediates multihormonal sensibility in transcriptional activation of the lactoferrin gene.  Mol. Cell. Biol. 15: 4194-4207. 1995.

37.  Alam, M., Zhestkov, V., Sani, B.P., Venepally, P., Levin, A.A., Kazmer, S., Li, E., Norris, A.W., Zhang, X-k., Lee, M.-O., Hill, D.L., Lin, T.-H., Brouillette, and Muccio, D.D.  Conformationally defined 6-s-trans retinoic acid analogs. 2: Selective agonists for nuclear receptor binding and transactivational activity.  J. Med. Chem. 38: 2302-2310. 1995.

38.  Dawson, M.I., Chao, W-R., Pine, P., Jong, L., Hobbs, P.D., Rudd, C., Quick, T.C., Niles, R.M., Zhang, X-k., Lombardo, A., Ely, K.R., Shroot, B., and Fontana, J.A.  Correlation of retinoid binding affinity to RAR? with retinoid inhibition of growth of estrogen receptor-positive MCF-7 mammary carcinoma cells.  Cancer Res. 55: 4446-4451. 1995.

39.  Zhang, X-k., Liu, Y., and Lee, M-O.  Retinoid receptors in human lung cancer and breast cancer.  Mutat. Res. 350: 267-277. 1996.

40.  Liu, Y., Lee, M-O., Wang, H-G., Li, Y., Hashimoto, Y., Klaus, M., Reed, J., and Zhang, X-k.  RAR? mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells.  Mol. Cell. Biol. 16: 1138-1149. 1996.

41.  Sani, P., Zhang, X.-k., Hill, D.L., and Shealy, Y.F.  Retinyl methyl ether: binding to transport proteins and effect on transcriptional regulation.  Biochem. Biophys. Res. Comm. 223: 293-298. 1996.

42.  Sani, B.P., Venepally, P., Zhang, X-k., Hill, D.L., and Shealy, F.  Biochemical characteristics and differentiating activity of 4-oxo analogs of retinoic acid.  Anticancer Res. 16: 1177-1181. 1996.

43.  Wu, Q., Li, Y., Liu, R., Agadir, A., Lee, M-O., Liu, Y., and Zhang, X-k.  Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nur77 and COUP-TF and their heterodimerization.  EMBO J. 16: 1656-1669. 1997.

44.  Agadir, A., Shealy, Y. F., Hills, D.L., and Zhang, X-k.Retinyl methyl ether down-regulates activator protein 1 transcriptional activation in breast cancer cells.  Cancer Res. 57: 3444-3450. 1997.

45.  Wu, Q., Dawson, M.I., Zheng, Y., Hobbs, P.D., Agadir, A., Jong, L., Li, Y., Liu, R., Lin, B., and Zhang, X-k.  Inhibition of trans-RA-resistant human breast cancer cell growth by retinoid X-receptor-selective retinoids.  Mol. Cell. Biol. 17: 6598-6608. 1997.

46.  Chao, W-r, Hobbs, P.D., Jong, L., Zhang, X-k., Zheng, Y., Wu, Q., Shroot, B., and Dawson, M.I.  Effects of receptor class- and subtype-selective retinoids and an apoptosis-inducing retinoid on the adherent growth of the NIH:OVCAR-3 ovarian cancer cell line in culture.  Cancer Lett. 115: 1-7. 1997.

47.  Giannini, G., Dawson, M.I., Zhang, X-k., and Thiele, C.J.  Activation of three distinct RXR/RAR heterodimers induces growth arrest and differentiation of neuroblastoma cells.  J. Biol. Chem. 272: 26693-26701. 1997.

48.  Li, Y., Dawson, M.I., Agadir, A., Lee, M-O., Jong, L., Hobbs, P.D., and Zhang, X-k.  Regulation of RAR beta expression by RAR- and RXR-selective retinoids in human lung cancer cell lines: effect on growth inhibition and apoptosis induction.  Int. J. Cancer 75: 88-95. 1998.

49.  Muccio, D.D., Brouillette, W.J., Breitman, T.R., Taimi, M., Emanuel, P.D., Zhang, X-k., Chen, G-q., Sani, B.P., Venepally, P., Lakshimi, R., Alam, M., Simpson-Herren, L., and Hill, D.L.  Conformationally defined retinoic acid analogues. 4, potential new agents for acute promyelocytic and juvenile myelomonocyticleukemias.  J. Med. Chem. 41: 1679-1687. 1998.

50.  Liu, R., Takayama, S., Zheng, Y., Froesch, B., Chen, G-q., Zhang, X., Reed, J.C., and Zhang, X-k.  Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells.  J. Biol. Chem. 273: 16985-16992. 1998.

51.  Li, Y., Lin, B., Agadir, A., Liu, R., Dawson, M.I., Reed, J.C., Fontana, J.A., Bost, F., Hobbs, P.D., Zheng, Y., Chen, G.Q., Shroot, B., Mercola, D., and Zhang, X-k.  Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines.  Mol. Cell. Biol. 18: 4719-4731. 1998.

52.  Dawson, M.I., Chao, W.R., Hobbs, P.D., and Zhang, X-k.  Effects of trans-retinoic acid, 9-cis-retinoic acid, 1alpha, 25-(dihydroxy) vitamin D3 and a novel apoptosis-inducing retinoid on breast cancer and endothelial cell growth.  Cancer Lett. 133: 1-8. 1998.

53.  Agadir, A., Lazzaro, G., Zheng, Y., Zhang, X-k., and Mehta, R.G.  Resistance of HBL100 human breast epithelial cells to vitamin D action.  Carcinogenesis 20: 577-582. 1999.

54.  Li, Y., Hashimoto, Y., Agadir, A., Kagechika, H., and Zhang, X-k.  Identification of a novel class of retinoic acid receptor ?-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells.  J. Biol. Chem. 274: 15360-15366. 1999.

55.  Agadir, A., Chen, G-q., Bost, F., Li, Y., Mercola, D., and Zhang, X-k.  Differential effect of retinoic acid on growth regulation by phorbol ester in human cancer cell lines.  J. Biol. Chem. 274: 29779-29785. 1999.

56.  Lin, B., Chen, G-q., Xiao, D., Kolluri, S.K., Cao, X., Su, H., and Zhang, X-k.Orphan receptor COUP-TF is required for induction of retinoic acid receptor ?, growth inhibition and apoptosis by retinoic acid in cancer cells.  Mol. Cell. Biol. 20: 957-970. 2000.

57.  Dawson, M.I., Hobbs, P.D., Jong, L., Xiao, D., Chao, W-r., Pan, C., and Zhang, X-k.sp2-bridgeddiarylretinoids: effect of bridge-region substitution on retinoid X receptor (RXR) selectivity.  Bioorg. Med. Chem. Lett. 10: 1307-1310. 2000.

58.  Dawson, M.I., Jong, L., Hobbs, P.D., Xiao, D., Feng, K.C., Chao, W-r., Pan, C., Fontana, J.A., and Zhang, X-k. 4-[3-(5,6,7,8-Tetrahydro-5,5,8,8,-tetramethyl-2-naphthalenyl)-phenyl]benzoic acid and hetercyclic-bridged analogs are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists.  Bioorg. Med. ChemLett. 10: 1311-1313. 2000.

59.  Lin, F., Xiao, D., Kolluri, S.K., and Zhang, X-k.Unique anti-activator protein-1 activity of retinoic acid receptor-?.  Cancer Res. 60: 3271-3280. 2000.

60.  Dawson, M.I., Zhang, X-k., Hobbs, P.D., and Jong, L.  Synthetic retinoids and their usefulness in biology and medicine. Vitamin A and retinoids: an update of biological aspects and clinical applications.  M.A. Livrea (ed.), Birkh?userVerlag Basel/Switzerland.pp161-196. 2000.

61.  Li, H., Kolluri, S., Gu, J., Dawson, M.I., Cao, X., Hobbs, P., Lin, B., Chen, G-q., Lu, J-s., Lin, F., Xie, Z., Fontana, J. A., Reed, J. C., and Zhang, X-k.  Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.  Science. 289: 1159-1164. 2000.

62.  Dawson, M.I., Park, J., Chen, G-q., Chao, W-r., Dousman, L., Waleh, N., Hobbs, P., Jong, L., Toll, L., Zhang, X-k., Gu, J., Agadir, A., Merchant, J., Bai, L., Verma, A., Thacher, S., Chandraratna, R., Shroot, B., and Hill, D.  Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-Tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity by retonoids. A potential role for Trans-RA-induced ZBP-89 in ODC inhibition.  Int. J. Cancer. 91: 8-21. 2001.

63.  Dawson, M.I., Hobbs, P., Peterson, V., Leid, M., Lange, C., Feng, K., Chen, G., Gu, J., Li, H., Kolluri, S., Zhang, X-k., Zhang, Y., and Fontana, J.  Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity.  Cancer Research. 61: 4723-4730. 2001.

64.  Stelle-Perkins, G., Fang, W., Yang, X-H., Van Gele, M., Carling, T., Gu, J., Buyse, I.M., Fletcher, J.A., Liu, J., Bronson, R., Chadwick, R.B., de la Chapelle, A., Zhang, X-k., Speleman, F., and Huang, S.  Tumor formation and inactivation of RIZ1, an R?-binding member of a nuclear protein-methyltransferase superfamily.  Genes Dev. 15: 2250-2262. 2001.

65.  Chen, G-q., Lin, B., Dawson, M.I., and Zhang, X-k.Nicotine modulates the effects of retinoids on growth inhibition and RAR? expression in lung cancer cells.  Int. J. Cancer. 99: 171-178.2002.

67.  Zhang, Y., Dawson, M.I., Mohammad, R., Rishi, A.K., Farhana, L., Feng, K-C., Leid, M., Perterson, V., Zhang, X-k., Edelstein, M., Eilander, D., Biggar, S., Wall, N., Reichert, U., and Fontana, J.A.  Induction of apoptosis of human B-CLL and ALL cells by a novel retinoid and its non-retinoidal analog.  Blood. 100: 2917-2925. 2002.

68.  Lin, F., Kolluri, S., Chen, G-q., and Zhang, X-k.Regulation of Retinoic Acid-induced Inhibition of AP-1 Activity by Orphan Receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor.  J. Biol. Chem. 277: 21414-21422. 2002.

69.  Peterson, V.J., Barofsky, E., Deinzer, M.L., Dawson, M.I., Feng, K.C., Zhang, X-k., Madduru, M.R., and Leid, M.  Mass-spectrometric analysis of agonist-induced retinoic acid receptor gamma conformational change.  Biochemical Jour. 362: 173-181. 2002.

70.  Zhang, X-k.  Vitamin A and apoptosis in prostate cancer.  Endocrine-Related Cancer. 9: 87-102. 2002.

71.  Li, M., Song, S., Lippman, S.M., Zhang, X-k., Liu, X., Lotan, R., and Xu, X-c.  Induction of Retinoic Acid Receptor-? and Sensitivity to Retinoic Acid of Esophageal Cancer Cells Dependent on Cyclooxygenase-2 Expression.  Oncogene.21: 411-418. 2002.

72.  Dawson M.I. and Zhang, X-k.  Discovery and design of retinoic acid receptor and retinoid X receptor class- and subtype-selective synthetic analogs of all-trans-retinoic acid and 9-cis-retinoic acid.  Curr. Med. Chem. 9: 623-637. 2002.

73.  Zhang, Y., Dawson, M.I., Ning, Y., Polin, L., Parchment, R.E., Corbett, T., Mohammad, A.N., Feng, K-C., Farhana, L., Rishi, A.K., Hogge, D., Leid, M., Peterson, V.J., Zhang, X-k., Mohammad, R., Lu, J-S., Willman, C., VanBuren, E., Biggar, S., Edelstein, M., Eilender, D., and Fontana, J.A.  Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog.  Blood. 102: 3743-3752. 2003.

74.  Kolluri, S., Bruey-Sedano, N., Cao, X., Lin, B., Lin, F., Han, Y-h., Dawson, M.I., and Zhang, X-k.Mitogenic Effect of Orphan Receptor TR3 and its Regulation by MEKK1 in Lung Cancer Cells.  Mol. Cell. Biol. 23: 8651-8667. 2003.

75.  James, S., Lin, F., Kolluri, S., Dawson, M.I., and Zhang, X-k.Regulation of retinoic acid receptor ? expression by peroxisome proliferator-activated receptor ? ligands in cancer cells.  Cancer Res. 63: 3531-3538. 2003.

76.  Liu,  Y., Ren, H., Wu, C., Bai, S., Zhang, X-k., and Ru., B. Lin, B. Attenuation of zinc-induced neuronal death by the interaction of growth inhibitory factor with Rab3A in rat hippocampal neurons. NeurosciLett. 358: 149-152, 2004.

77.  Lin, B., Kolluri, S., Lin, F., Liu, W., Han, Y-h., Cao, X., Dawson, M.I., Reed, J.C., and Zhang, X-k.  Conversion of Bcl-2 from Protector to Killer by Interaction with Nuclear Orphan Receptor Nur77/TR3.  Cell. 116: 527-540. 2004.

78.  Castro-Obregón, S., Rao, R., del Rio, G., Chen, S., Poksay, K., Rabizadeh, S., Vesce, S., Zhang, X-k., Swanson, R., and Bredesen, D.  Alternative, non-apoptotic programmed cell death: mediation by Arrestin 2, ERK2 and Nur77.  J Biol Chem. 279: 17543-17553. 2004.

79.  Dawson, M.I., Harris, D., Liu, G., Hobbs, P., Lange, C., Jong, L., Bruey-Sedano, N., James, S., Zhang, X-k., Peterson, V., Leid, M., Farhana, L., Rishi, A., and Fontana, J.  Antagonist Analogue of 6-[3’-(1-Adamantyl)-4’–hydroxyphenyl]-2-naphthalenecarboxylic Acid (AHPN) Family of Apoptosis Inducers That Effectively Blocks AHPN-Induced Apoptosis but Not Cell-Cycle Arrest.  J. Med. Chem. 47: 3518-3536. 2004.

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