陈才勇教授

文章出处: 作者: 发布时间: 2015-02-17 访问次数: 1027

 

陈才勇

教授、博士生导师

866 Yuhangtang Road

Hangzhou 310058, China

Tel: 0571-88206497

Email: chency@zju.edu.cn

ZhejiangUniversity

College of Life Sciences

Lab: http://mypage.zju.edu.cn/chenlab

 

 

研究领域

铁离子/血红素代谢机制,红细胞发育与疾病,模式动物(秀丽线虫和斑马鱼) 生物学

 

教育和工作背景

2014-     教授      浙江大学生命科学学院

2011-2014 博士后    哈佛大学医学院,Brigham妇女医院(美国)

2009-2010 博士后    马里兰大学动物科学系(美国)

2003-2009 博士      马里兰大学动物科学系(美国)

1995-2003 学士、硕士南京农业大学动物科技学院

 

主要奖励及荣誉

2012 美国血液协会(ASH)第54届年会优秀摘要奖(Abstract Achievement Award)

2012 美国Gordon Research Conference四吡咯化合物分会旅行奖(Travel Award)

2009 美国Gordon Research Conference金属细胞生物学分会青年研究学者奖(Junior Investigator Award)

2009 美国马里兰大学农业与自然资源学院优秀研究生

2006 美国马里兰大学动物科学系优秀博士生

1998 南京农业大学明星学生

 

发表论文

1. Wu Q, Wang H, An P, Tao Y, Deng J, Zhang Z, Shen Y, Chen C, Min J, and Wang F. HJV and HFE Play Distinct Roles in Regulating Hepcidin. Antioxid Redox Signal 2015; in press.

2. Shmukler BE, Reimold FR, Heneghan JF, Chen C, Zhao T, Paw BH, and Alper SL. Molecular cloning and functional characterization of zebrafish Slc4a3/Ae3 anion exchanger. Pflugers Arch 2014; 466:1605-18.

3. Chen C, Santos D, Ishikawa Y, Seguin A, Li L, Fegan KH, Hildick-Smith GJ, Cooney JD, Chen W, King MJ, Schultz IJ, Dalton AJ, Kingsley P, Palis J, Hattangadi SM, Lodish HF, Ward D, Kaplan J, Maeda T, Ponka P, and Paw BH. Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metabolism 2013; 17:343-52.

4. Shah DI, Makise-Takahashi N, Cooney JD, Li L, Schultz IJ, Pierce EL, Narla A, Seguin A, Hattangadi S, Medlock AM, Langer LB, Dailey TA, Hurst SN, Faccenda D, Wiwczar JM, Heggers SK, Vogin G, Chen W, Chen C, Campagna D, Brugnara C, Zhou Y, Ebert BL, Danial NN, Fleming MD, Ward DM, Campanella M, Dailey H, Kaplan J, and Paw BH. Mtiochondrial Atpif1 regulates heme synthesis in developing erythroblasts. Nature 2012; 491:608-12.

5. Chen C and Paw BH. Cellular and mitochondrial iron homeostasis in vertebrates. Biochimica et Biophysica Acta -Molecular Cell Research 2012; 1823:1459-67.

6. Chung J, Chen C, and Paw BH. Heme metabolism and erythropoiesis. Current Opinion in Hematology 2012; 19: 156-62.

7. Chen C, Samuel TK, Krause MW, Dailey HA, and Hamza I. Heme utilization in the Caenorhabditis elegans hypodermal cells is facilitated by heme responsive gene -2. Journal of Biological Chemistry 2012; 287: 9601-12.

8. Chen C, Samuel TK, Sinclair J, Dailey HA, and Hamza I. An intercellular heme chaperone delivers maternal heme to the embryo during development in C. elegans. Cell 2011; 145: 720-31.

9. Schultz IJ*, Chen C*, Paw BH, and Hamza I. Iron and porphyrin trafficking in heme biogenesis. Journal of Biological Chemistry 2010; 285: 26753-9. (* Co-equal first author)

10. Severance S, Chen C, and Hamza I. Eukaryotic heme trafficking. In: Kadish KM, Smith KM, and Guilard R, editors. Handbook of Porphyrin Science. World Scientific Publishing Company, Singapore. 2010; 15: 1-48.

 

课题资助

2015-2018 参与国家973 计划项目牛羊重要寄生虫致病机制的分子基础

2014-2017 主持国家自然科学基金面上项目细胞间血红素分子伴侣HRG-3 的功能机理研究

2011-2013 主持美国库利贫血基金会(Cooley’s Anemia Foundation)科研项目“Iron and Heme Trafficking in Red Cells”