金勇丰教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 1501

 

金勇丰教授

杭州市余杭塘路866号浙大紫金港校区

浙江大学生命科学学院

邮编:310058

电话:0571-88206478

手机:13003680728

jinyf@zju.edu.cn

 

金勇丰,男,1969.10出生,博士,浙江大学生命科学学院教授、博士生导师,生物技术系副主任,《中国科学》杂志编委。主要从事RNA可变剪接和编辑研究。目前主持国家自然科学杰出青年基金和国家自然科学基金重点项目等课题。在Nat Struct Mol Biol, Nat Commun等国内外著名学术期刊发表通讯作者学术论文20余篇。

 

1.学习简历

1987.9--1997.7,浙江农业大学园艺系果树专业,本科生、硕士研究生、博士研究生。

2.科研经历

2004.12至现在,浙江大学生命科学学院,教授、博士生导师。期间,在奥地利维也纳大学染色体系(2006.12-2007.5)和美国布朗大学(2008.11-2009.2)短期高访。

1997.9-2004.12,浙江(农业)大学生命科学学院()助教、讲师、副教授。期间,在奥地利维也纳大学微生物与遗传研究所做访问学者1年(2002.5-2003.4)。

3. 主要人才计划

12014年,国家“万人计划”中青年科技领军人才

22013年,国家科技部中青年科技领军人才

32013年,浙江大学求是特聘教授

42011年,国家杰出青年基金获得者(生化与分子生物学学科)

52010年,浙江省“新世纪151人才工程”重点资助

62009年,浙江省自然科学杰出青年基金获得者

72007年,浙江省青年科技奖获得者

82004年,教育部“新世纪优秀人才支持计划”获得者

4.近期发表的论文(*通讯作者):

1)    Zhang W, Wang Y, Dong S, Choudhury R, Jin Y, Wang Z. Treatment of type 1 myotonic dystrophy by engineering site-specific RNA endonucleases that target (CUG)n Repeats. Mol Ther, 2014. 2:312-320.

2)    Li S, Wei Z, Chen J, Chen Y, Lv Z, Yu W, Meng Q, Jin Y*. Oral administration of a fusion protein between the cholera toxin B subunit and the 42-amino acid isoform of amyloid-β peptide produced in silkworm pupae protects against Alzheimer's disease in mice. PLoS One. 2014.9:e113585.

3)    Yang Y, Zhou X, Jin Y*.ADAR-mediated RNA editing in non-coding RNA sequences. Sci China Life Sci. 2013; 56: 944-952.

4)    Yue Y, Li G, Yang Y, Zhang W, Pan H, Chen R, Shi F, Jin Y*. Regulation of Dscam exon 17 alternative splicing by steric hindrance in combination with RNA secondary structures. RNA Biol. 2013.10:1822-1833.

5)    Wang X, Li G, Yang Y, Wang W, Zhang W, Pan H, Zhang P, Yue Y, Lin H, Liu B, Bi J, Shi F, Mao J, Meng Y, Zhan L, Jin Y*. RNA architectural local control region in Dscam mutually exclusive splicing. Nat Commun, 2012; 3:1255.

6)    Yang Y, Sun F, Wang X, Yue Y, Wang W, Zhang W, Zhan L, Tian N, Shi F, Jin Y*, Conservation and regulation of alternative splicing by dynamic inter- and intra-intron base pairings in Lepidoptera 14-3-3z pre-mRNAs. RNA Biol. 2012; 9. 691-700.

7)    Jin Y*, Yang Y, Zhang P. New insight into RNA secondary structure on alternative splicing of pre-mRNA. RNA Biol, 2011, 8: 450-457

8)    Yang Y, Zhan L, Zhang W, Sun F, Wang W, Tian N, Bi J, Wang H, Shi D, Jiang Y, Zhang Y, Jin Y*. RNA secondary structure in mutually exclusive splicing. Nat Struct Mol Biol, 2011, 18: 159-68

9)    Tian N, Yang Y, Sachsenmaier N, Muggenhumer D, Bi J, Waldsich C, Jantsch MF, Jin Y*. A structural determinant required for RNA editing. Nucl Acids Res, 2011, 39: 5669-5681

10)  Meng Y, Gou L, Chen D, Mao C, Jin Y, Wu P, Chen M. PmiRKB: a plant microRNA knowledge base. Nucleic Acids Res, 2011, 39: D181-7. (SCI, IF=7.48)

11)  Meng Y, Chen D, Jin Y, Mao C, Wu P, Chen M.RNA editing of nuclear transcripts in Arabidopsis thaliana. BMC Genomics, 2010,11 Suppl 4:S12.

12)  Lv, J, Yang Y, Ying H, Zhu F, Wang H, Zhang WZhang Y, Jin Y*. Molecular determinants and evolutionary dynamics of wobble splicing. Mol Biol Evol, 2009, 26:1081-1092 (SCI, IF=9.87)

13)  Jin Y*, Zhang W, Li Q. Origins and evolution of ADAR-mediated RNA editing. IUBMB Life (Critical Review), 2009, 61:572-578. (SCI, IF=3.58)

14)  Zhang Y, Xia Q, Xu J, Chen J, Nie Z, Wang D, Zhang W, Chen J, Zheng Q, Chen Q, Kong L, Ren X, Wang J, Lv Z, Yu W, Jiang C, Liu L, Sheng Q, Jin Y, Wu X. Aligning the proteome and genome of the silkworm, Bombyx mori. Funct Integr Genomics, 2009, 9: 447-454

15)  Yang Y, Lv, JN, Gui B, Ying H, Wu X, Zhang Y*, Jin Y*. A-to-I RNA editing alters less-conserved residues of highly conserved coding regions: Implications for its dual functions in evolution. RNA, 2008, 14: 1516-1525

16)  Tian N, Wu X, Zhang Y, Jin Y*. A-to-I editing sites were a genomically encoded G: Implications for evolutionary significance and identification of novel editing sites. RNA, 2008,14: 211-216

17)  Zhang Y, Lv Z, Chen J, Chen Q, Quan Y, Kong L, Zhang H, Li S, Zheng Q, Chen J, Nie Z, Wang J, Jin Y, Wu X. A novel method for isolation of membrane proteins: a baculovirus surface display system. Proteomics, 2008, 8: 4178-85

18)  He P, Nie Z, Chen J, Chen J, Lv Z, Sheng Q, Zhou S, Gao X, Kong L, Wu X, Jin Y*, Zhang Y*. Identification and characteristics of microRNAs from Bombyx mori. BMC Genomics, 2008, 9: 248

19)  Cao J, Wu X, Jin Y*. Lower GC-content in editing exons: Implications for regulation by molecular characteristics maintained by selection. Gene, 2008, 421:14-19

20)  Cao J, Tong CZ, Wu X, Lv J, Yang Z, Jin Y*. Identification of conserved microRNAs in Bombyx mori (silkworm) and regulation of fibroin L chain production by microRNAs in heterologous system. Insect Biochem Mol Biol, 2008, 38:1066-1071

21)  Jin Y*, Tian N, Cao J, Liang J, Yang Z, and Lv J. RNA editing and alternative splicing of the insect nicotinic acetylcholine receptor subunit α6 transcript: evolutionary conservation, divergence and regulation. BMC Evol Biol, 2007, 7: 98

22)  Gong Z, Jin Y*, Zhang Y*. Suppression of diabetes in non-obese diabetic (NOD) mice by oral administration of a cholera toxin B subunit-insulin B chain fusion protein vaccine produced in silkworm, Vaccine, 2007, 25:1444-1451.

23)  Jin Y, Tashpulatov AS, Katholnigg H, Heberle-Bors E and Touraev A. Isolation and characterization of the two wheat β-expansin genes expressed during male gametophyte development. Protoplasma, 2006, 228: 13-19 (SCI)

24)  Gong Z, Jin Y*, Zhang Y*. Incorporation of partial polyhedrin homology sequences (pphs) enhances the production of cloned foreign genes in a baculovirus expression system. Biotechnol Appl Biochem, 2006, 43: 165-170

25)  Tong C, Jin Y*, Zhang Y. Computational identification of microRNA genes in silkworm genome. ZJUS, 2006, 7: 806-816

26)  Chen J, Liu T, Zhu C, Jin Y, Zhang Y. Genetic variation of Chinese PRRSV strains based on ORF5 sequence. Biochem Genet, 2006, 44: 425-435 (SCI)

27)  Gong Z, Jin Y*, Zhang Y*. Oral administration of a cholera toxin B subunit-insulin fusion protein produced in silkworm protects against autoimmune diabetes. J of Biotechnol, 2005, 119: 93-105

28)  Jin Y*, Chen Y, Gong Z. Determination and analysis of the pre-mRNA cleavage sites in Arabidopsis. RNA Biol, 2005, 2: 83-85

29)  Gong Z, Jin H, Jin Y*, Zhang Y*. Expression of cholera toxin B subunit and assembly as functional oligomers in silkworm. J Biochem Mol Biol, 2005, 38: 717-724

30)  Jin Y*, Bian T. Nontemplated nucleotide addition prior to polyadenylation: A comparison of Arabidopsis cDNA and genomic sequences, RNA, 2004, 10: 1695-1697

 

5.承担的主要科研项目:

1) 国家自然科学基金重点项目,竞争RNA二级结构调控互斥可变剪接的新机制研究, 330万元,2015-2019(排名第一)

2) 国家自然科学杰出青年基金, RNA可变剪接和编辑研究, 200万元,2012-2015(排名第一)

3) 国家重大科技专项子课题, 新型I型糖尿病口服药物的研制和中试,  389万元,2012-2015(排名第一)