何向伟教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 624

 

个人信息

姓名:  何向伟

生日:  1967924

国籍:  美国

 

教育经历:

    高中

       上海第五十一中学/中国上海, 19818月-19847

    大学

       复旦大学/中国上海,理学士, 19848月-19887

    研究生

       贝勒医学院生物医学研究生院,哲学博士,

19918月-199712

导师: Shelley Sazer, 哲学博士,副教授

论文:裂殖酵母有丝分裂的调控

博士后培训:

    博士后学者,麻省理工学院生物系,19981月-20019

    博士后奖学金,美国国立卫生研究院, 1998 2001

    导师: Peter Sorger, 哲学博士,教授

学术职位:

德州大学休斯顿医学院生物化学和分子生物学系助理教授200110月至20046

贝勒医学院助理教授,副教授(20133月升职)

分子及人类遗传学系(主要职位)生物化学和分子生物学系(兼职)200471日起。

浙江大学生命科学研究院教授、博士生导师、资深研究员20138月至今

 


 

科研信息

 

A.科研资助

裂殖酵母中着丝体与纺锤体的相互作用

国立卫生研究院普通医学科学 RO1 GM068676

何向伟(主持人)

直接资助 $175000/每年,总直接资助 $11,575,000

200381日-2008730

200991日-2013830

 

浙江大学生命科学研究院学术特区建设项目经费

985项目子项目 181220-193534101/013

何向伟(负责人)总资助¥6000,000

2013-2018

 

DNA损伤修复蛋白的作用机制

中国科技部 973项目子项目 2015CB910602

1500,000

2015-2019

 

B.发表论文

 

1.Shi, Z-Z., Carter, B.Z., Habib, G.M., He. X., Sazer, S., Lebovitz, R.M., and Lieberman, M.W. (1996) A single mouse glutathione synthetase gene encodes six mRNAs with different 5' ends. Arch. Biochem. Biophys 331: 215- 224.

2.Shi, Z-Z., Habib, G.M., Rhead, W.J., Gahl, W.A., He. X., Sazer, S., and     Liebermen, M.W. (1996) Mutations in the glutathione synthetase gene causes 5-oxoprolinuria.  Nature Genetics 14 (3): 361-365.

3.Noguchi, E., Hayashi, N., Yanagida, M., He, X., Mueller, U.W., Sazer, S. and Nishimoto, T. (1996) Dis3, implicated in mitotic control, binds directly to Ran   and enhances the GEF activity of RCC1. EMBO J. 15: 5595-5605.

4.Matynia, A., Dimitrov, K., Mueller, U.W., He, X., and Sazer, S. (1996)       Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through     its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences. Mol.    Cell. Biol. 16 (11): 6352-6362.

5.He, X., Patterson, T.E., and Sazer, S. (1997) The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex.   Proc Natl Acad     Sci U S A. 94(15): 7965-70.

6.He, X., Jones, M. H., Winey, M. and Sazer, S. (1998) Mph1, a member of the Mps1-like family of dual specificity protein kinases, is required for the spindle checkpoint in S. pombe. J. Cell Science. 111: 1635-47.

7.Balasubramanian, M.K., McCollum, D., Chang, L, Wong, K.C., Naqvi, N.I.,

He, X., Sazer, S. and Gould, K.L. (1998) Isolation and characterization of new     fission yeast cytokinesis mutants. Genetics 149(3): 1265-75.

8.He, X., Hayashi, N., Walcott, N., Azuma, Y., Patterson, T.E., Nishimoto, T., and Sazer, S. (1998) The identification of cDNAs that affect the mitosis-to-interphase transition in Schizosaccharomyces pombe, including sbp1, which encodes a spi1p-GTP-binding protein.       Genetics 148(2): 645-656.

9.He, X., Asthana, S. and Sorger, P.K. (2000) Transient sister chromatid separation and elastic deformation of chromosomes during mitosis in budding yeast. Cell       101: 763-775.

10.He, X., Rines, D., Espelin, C. and Sorger, P. K. (2001) Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell 106:195-206

11.Jones, M. H., He, X. and Winey, M. (2001) Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle.Proc Natl Acad Sci U S A. 98 (24):13675-80.

12.Meriin, A. B., Zhang, X., He, X., Newman, G. P., Chernoff, Y. O. and Sherman, M. Y. (2002) Huntingtin toxicity in yeast model depends on polyglutamine        aggregation mediated by a prion-like protein Rnq1.  J. Cell Biology 157 (6) 997-1004.

13.Rines, D.R., He, X. and Sorger, P. K. (2002) Quantitative microscopy of green fluorescent protein-labeled yeast. Methods Enzymol. 351:16-34.

14.Kadura S, He X, Vanoosthuyse V, Hardwick KG and Sazer S. (2004)  The A78V Mutation in the Mad3-like Domain of Schizosaccharomyces pombe Bub1p Perturbs  Nuclear Accumulation and Kinetochore Targeting of Bub1p, Bub3p,    Mad3p and Spindle Assembly Checkpoint function.  Mol. Biol. Cell 16 (1): 385-95

 15.Liu X, McLeod I, Anderson S, Yates J.3rd and He X. (2005) Molecular analysis of the kinetochore architecture in fission yeast.  EMBO J 24(16): 2919-30

16.Joglekar, A.P., Bouck, D., Finley, K., Liu, X., Wan, Y., Berman, J., He, X., Salmon, E.D., Bloom, K.S. (2008) Molecular architecture of the kinetochore-       microtubule attachment site is conserved between point and regional centromeres.        J Cell Biol. 181(4): 587-94

17.Song J.S., Liu X., Liu X.S. and He, X. (2008) A high-resolution map of nucleosome positioning on a fission yeast centromere.  Genome Res. 18(7): 1064-72

18. Yao J., and He, X. (2008) Kinetochore assembly: building a molecular machine that drives chromosome movement.  Mol. BioSysems. 10: 1039/b719627 

19.Ezzeddine, N., Zheng, D., Chen C.A., Zhu W., He, X. and Shyu A. (2008).Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells.      J Cell Biol.14;182 (1):89-101

20.Lu, N., Yu, X., He, X., and Zhou, Z. Detecting apoptotic cells and monitoring   their clearance in the nematode Caenorhabditis elegans. Methods Mol. Biol.   (2009) 559: 357-70.

21.Pidoux, A.L., Choi, E.S., Abbott, J., Liu, X., Kagansky, A., Castillo, A.G., Hamilton, G.L., Richardson, W., Rappsilber, J., He, X. and Allshire, R. C. (2009)   Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin. Mol. Cell 33; (3):299-311

22.Kim JH, Zhao Y, Pan X, He X, Gilbert HF. (2009) The unfolded protein response is necessary but not sufficient to compensate for defects in disulfide isomerization.      J Bio Chem 284 (16): 10400-8.

23.Gao, Q., Courtheoux, T., Gachet, Y., Tournier, S. and He, X. (2010) A non-ring-like form of the Dam1 complex modulates microtubule dynamics in fission yeast.    PNAS 107(30):13330-5

24.Xi,Y., Yao, J., Chen, R., Li, W. and He, X. (2011) Nucleosome fragility reveals novel functional states of chromatin and poises genes for activation.Genome Research 21(5): 718-24

25.Chen, K., Xi, Y., Pan, X., Li, Z., Kaestner, K., Tyler, J., Dent, S., He, X., Wei Li

DANPOS: Dynamic Analysis of Nucleosome Position and Occupancy by Sequencing. (2013)      Genome Research 23(2):341-51

26.Yao J1, Liu X, Sakuno T, Li W, Xi Y, Aravamudhan P, Joglekar A, Li W, WatanabeY,He X. Plasticity and epigenetic inheritance of centromere-specific histone H3 (CENP-A)-containing nucleosome positioning in the fission yeast. 2013 J Biol Chem. 288(26):19184-96.

27.Courtwright A.M. and He, X. (2002) Dam1 is the right one: phosphoregulation of kinetochore biorientation.Developmental Cell 3: 610-1

28.Gao Q, Tanaka T.U, He X. (2006) GFP-based Microscopic Approaches for    Whole Chromosome Analysis in Yeasts.  In Yeast Gene Analysis (Academic   Press).

 

3.学术服务

 

1.  生物化学杂志,编委  (任期2009 - 2014)