方群教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 1353

 

方群教授

 

个人简介

方群,博士,浙江大学化学系求是特聘教授,博士生导师,浙江大学微分析系统研究所所长。1998年毕业于沈阳药科大学大学,获药物分析学博士学位。19981999年,在香港浸会大学化学系任博士后研究助理,1999年被引进到浙江大学工作,主要从事微流控分析领域的研究工作。主要研究方向包括微流控液滴分析和微流控分离检测技术研究,微型化分析仪器的研制,以及微流控分析系统在高通量筛选、快速生物分析、临床检验、蛋白质组和单细胞分析中的应用。主持国家和省部级科研项目12项,包括国家自然科学基金重大项目课题、重点项目、杰出青年基金、科学仪器研制专项、面上项目、国家科技部973项目课题、863计划课题等,2008年获得国家自然科学基金委杰出青年基金资助。发表SCI论文90余篇。在微流控分析领域,申请国家发明专利23项,其中14项已获授权。目前担任中国化学会有机分析专业委员会委员,中国微米纳米技术学会理事。担任国际分析化学期刊“AnalyticaChimicaActa”、“Analyst”和“Analytical Bioanalytical Chemistry”编委,以及国内分析化学期刊“分析化学”、“色谱”、“分析科学学报”、“化学传感器”、“光谱学与光谱分析”的编委。

 

发表论文目录

1.    D-Q. Jin, Y. Zhu, Q. Fang*, Swan probe: a nanoliter-scale and high-throughput sampling interface for coupling electrospray ionization mass spectrometry with microfluidic droplet array and multiwell plate, Anal. Chem. 2014, 86, 10796-10803.

2.    T. Zhang, J-L. Fu, Q. Fang*, Improved high-speed capillary electrophoresis system using a short capillary and picoliter-scale translational spontaneous injection,Electrophoresis, 2014, 35, 2361-2369.

3.    Y. Zhu, L-N. Zhu, R.Guo, H-J. Cui, S. Ye, Q. Fang*, Nanoliter-scale protein crystallization and screening with a microfluidic droplet robot, Sci. Rep., 2014, 4, 5046.

4.    Y-Q. Cheng, Y. Su, X-X. Fang, J-Z. Pan, Q.Fang*,A simple fabrication method for tapered capillary tip and its applications in high-speed CE and ESI-MS, Electrophoresis, 2014, 35, 1484-1488.

5.  方群,多相微流控分析与毛细管电泳研究进展,色谱,201432673-674

6.  章豪,方群*,范杰*,微量组合催化剂筛选技术,化学进展,201426512-521

7.S-Z.Wu, Z-Y.Zhou, L-R.Xu, B.Su*, Q.Fang*, Integrating bipolar electrochemistry an delectrochemiluminescence imaging with microdroplets for chemical analysis, Biosens.Bioelectro., 2014, 53, 148-153.

8.  朱丽娜,祝莹*方群*,基于微流控技术的蛋白质结晶及其筛选方法的研究进展,高等学校化学学报,2014351-11

9.   X-L. Wang,Y. Zhu, Q. Fang*, Coupling liquid chromatography/massspectrometry detection with microfluidic dropletarray for label-free enzyme inhibition assay, Analyst, 2014, 139, 191-197.

10.  H. Zhang, J-J. Wang, J. Fan*,Q. Fang*,Microfluidic chip-based analytical system for rapid screeningof photocatalysts, Talanta, 2013, 116, 946-950.

11.  C-Q. Lin, Y-X. Zhang, X. Zhou, B. Yao*, Q. Fang,Naked-eye detection of nucleic acids through rolling circle amplification and magnetic particle mediated aggregation,Biosens.Bioelectro., 2013, 47, 515-519.

12.  Y. Zhu, Q. Fang*,Analytical detection techniques for droplet microfluidics—A review, Anal.Chim.Acta, 2013, 787, 24-35.

13.  Y. Zhu, Y-X. Zhang, L-F.Cai, Q. Fang*, Sequential operation droplet array: an automated microfluidic platform for picoliter-scale liquid handling, analysis, and screening, Anal. Chem. 2013, 85, 6723-6731.

14.  G-S. Du, J-Z. Pan, S-P. Zhao, Y. Zhu, J. M.J. den Toonder, Q. Fang*,Cell-based drug combination screening with a microfluidic droplet array system, Anal. Chem. 2013, 85, 6740-6747.

15.  Y. Zhu, N-N. Chen, Q. Li, Q. Fang*, Improving the sensitivity of confocal laser inducedfluorescence detection to the sub-picomolar scale forround capillaries by laterally shifting the laser focuspoint, Analyst, 2013, 138, 4642-4648.

16.李启,张婷,方群*,基于短毛细管的高速毛细管电泳系统的研究进展,分析化学,201341650-657

17.Q. Li, T. Zhang, Y. Zhu, Y-Q Cheng, Q-H. Lin, Q. Fang*, Automated high-speed CE systemfor multiple samples, Electrophoresis, 2013, 34, 557-561.

18.  Q-Q.Ji, G-S. Du, M. J. van Uden, Q. Fang*, J. M. J. den Toonder*, Microfluidic cytometer based on dual photodiode detection for cell size and deformability analysis, Talanta, 2013, 111, 178-182.

19.  Y. Su, Y. Zhu, Q. Fang*, A multifunctional microfluidic droplet-array chip foranalysis by electrospray ionization mass spectrometry, Lab Chip, 2013, 13, 1876-1882.

20.  H. Yi, J-Z. Pan, X-T. Shi,Q. Fang*, Automated liquidoperationmethodformicrofluidicheterogeneous immunoassay, Talanta, 2013, 105, 52-56.

21.  Y. Zhu, H. Chen, G-S. Du, Q. Fang*, Microfluidic droplet-array liquid-liquid chromatography based on droplet trapping technique, Lab Chip, 2012, 12, 4350-4354.

22.  X-L. Wang, Y. Zhu, Q. Fang*, Valveless gated injection for microfluidic chip-based liquid chromatographysystem with polymer monolithic column, J.Chromatogr. A, 2012, 1246, 123-128.

23.  J-F. Fan, Y. Zhu, X-T. Shi, Q. Fang*, J. Huang*, Microfluidic sequential injection analysis system based onpolydimethylsiloxane (PDMS) chip with integratedpneumatic-actuated valves, Science China Chemistry, 2012, 55, 531-536.

24.  L-F. Cai, Y. Zhu, G-S. Du, Q. Fang*, Droplet-based microfluidic flow injection system with large-scaleconcentration gradient by a single nanoliter-scale injection forenzyme inhibition assay, Anal. Chem., 2012, 84, 446-452.

25.潘建章,方群*,微流控床边检验系统的流体操控方法研究进展,分析化学, 20124011-17

26.Z-Q. Yu, Y. Zhu, Y-X. Zhang, J. Li, Q. Fang, J-Z. Xi, Y. Bo*, Nanoliter droplet array for microRNA detection based on enzymatic stem-loop probes ligation and SYBR Green real-time PCR, Talanta, 2011, 85, 1760-1765.

27.  S-Q. Gu, Y-X.Zhang, Y. Zhu, W-B.Du, B. Yao, Q. Fang*, Multifunctional picoliter droplet manipulation platform and itsapplication in single cell analysis, Anal. Chem., 2011, 83, 7570-7576.

28.  Q-H. Lin, Y-Q. Cheng, Y-N. Dong, Y. Zhu, J-Z. Pan, Q Fang*, High-speed separation of proteinsby sodium dodecyl sulfate-capillary gelelectrophoresis with partial translationalspontaneous sample injection, Electrophoresis, 2011, 32, 1-6.

29.  S-Z. Wu, Y-X. Zhang, H. Shen, B. Su*, Q. Fang*, Microfluidic droplet-based liquid/liquid extraction modulated by the interfacial Galvani potential difference, Chem. Comm., 2011, 47, 5723-5725.

30.  Y-X. Zhang, Y. Zhu, B. Yao*, Q. Fang*, Nanolitre droplet array for real time reverse transcription polymerase chain reaction, Lab Chip, 2011, 11, 1545-1549.

31.  G-S. Du, A.Ravetto, Q. Fang, J. M. J. den Toonder*, Cell types can be distinguished by measuring their viscoelastic recovery times using a micro-fluidic device, Biomed.Microdev. 2011, 13, 29-40.

32.王新珏,祝莹,方群*,基于微流控芯片的色谱技术的研究进展及其应用,色谱,2011299-104

33.  W-B. Du, M. Sun, S-Q.Gu, Y. Zhu, Q. Fang*, Automated microfluidic screening assay platformbased on DropLab, Anal. Chem., 2010, 82, 9941-9947.

34.  Z-Q. Wu, X-D.Cao, L. Chen, J-R.Zhang, X-H.Xia*, Q. Fang*, H-Y.Chen, Study on the influence of cross-sectional area and zeta potential on separation for hybrid-chip-based capillary electrophoresis using 3-D simulations, Electrophoresis, 2010, 31, 3665-3674.

35.  Y. Zhu, Q. Fang*,Integrated droplet analysis system withelectrospray ionization-mass spectrometry usinga hydrophilic tongue-based droplet extractioninterface, Anal. Chem., 2010, 82, 8361-8366.

36.  Y-Q. Cheng, B. Yao, H-D.Zhang, J. Fang, Q. Fang*, An automated capillary electrophoresis system for high-speed separation of DNA fragments based on a short capillary, Electrophoresis, 2010, 31, 3184-3184.

37.  M. Sun, Q. Fang*, High-throughput sample introduction for droplet-based screening with anon-chip integrated sampling probe and slotted-vial array, Lab Chip, 2010, 10, 2864-2868.

38.  J-Z. Pan, B. Yao, Q. Fang*, Hand-held photometer based on liquid-corewaveguide absorption detection fornanoliter-scale samples, Anal. Chem., 2010, 82,3394-3398.

39.  Y. Zhu, J.-Z. Pan, Y. Su, Q-H. He, Q. Fang*, Fabrication of low-melting-point alloy microelectrode and monolithic spray tipfor integration of glass chip with electrospray ionization mass spectrometry, Talanta, 2010, 81, 1069-1075.

40.沈玉勤,姚波*方群*,磁场控制技术在微流控芯片中的应用,化学进展,201022133-139

41.  Q. Fang, P. K. Dasgupta, Young analytical chemists in China preface, Anal. Chim. Acta, 2009, 650, 1-2.

42.姚波,何巧红,杜文斌,石晓彤,方群*,微流控高通量试样引入技术的研究进展,色谱,200927662-666

43.  T. Zhang, Q. Fang*, W-B.Du, J-L. Fu, Microfluidic picoliter-scale translational spontaneous sample introduction for high-speed capillary electrophoresis, Anal. Chem., 2009, 81, 3693-3698.

44.  F-B. Yang, J.-Z. Pan, T. Zhang, Q. Fang*,A low-cost light-emitting diode induced fluorescence detector for capillaryelectrophoresis based on an orthogonal optical arrangement, Talanta, 2009, 78, 1155-1158.

45.  Q. Fang*, M. Sun, Y-Z.Huang, Capillary-based microfluidic analysis systems, Anal.Bioanal. Chem., 2009, 393, 63-66.

46.  X-F. Fan, Q. Li, S-L.Wang, Z-R. Xu*, W-B.Du, Q. Fang, Z-L. Fang, High-throughput analysis of DNA fragmentsusing a miniaturized CE system combinedwith a slotted-vial array sample introductionsystem, Electrophoresis, 2008, 29, 4733-4738.

47.  Q-H. He*, S. Chen, Y. Su, Q. Fang, H-W. Chen, Fabrication of 1D nanofluidic channels on glass substrate by wet etching and room-temperature bonding, Anal. Chim. Acta, 2008, 628, 1-8.

48.沈宏*,方群,微流控分析芯片的两种液相传质模式及其应用,化学进展,2008202053-2060

49.  Q. Fang*, X-T. Shi, W-B.Du, Q-H. He, H. Shen,Z-L. Fang, High-throughput microfluidicsample-introduction systems, TRAC-Trends in Anal. Chem., 2008, 27, 521-532.

50.  H. Shen, Q. Fang*, Improved microfluidic chip-based sequential-injection trapped-droplet arrayliquid–liquid extraction system for determination of aluminum, Talanta, 2008, 77, 269-272.

51.  Y-Z. Huang, W-B.Du, J.-Z. Pan, Q. Fang*, Microfluidic chip-based valveless flow injection analysis system withgravity-driven flows, Analyst, 2008, 133, 1237-1241.

52.董娅妮,方群*,微流控芯片毛细管电泳在蛋白质分离分析中的应用研究进展,色谱,200826269-273

53.叶晓兰,杜文斌,古淑青,潘建章,牟颖,方群*,小型微流控芯片流式细胞仪的研制,分析化学,2008361443-1446

54.程永强,张涛,王鹗,王伟,徐光明,方群*,激光诱导荧光检测微流控芯片生化分析仪的研制,分析化学,200836127-131

 

 

授权发明专利:

1方群,潘建章,易会,石晓彤,一种用于非均相免疫快速分析的自动化装置及其使用方法,中国发明专利,专利号:ZL 201210465463.6,专利申请日:20121119,授权公告日:201442

2方群,潘建章,用于微量液体分析的双波长吸收光度检测装置,中国发明专利,专利号:ZL 201010134196.5,专利申请日:2010329,授权公告日:201259

3方群,孙蒙,基于芯片一体化取样探针的液滴分析筛选装置,中国发明专利,专利号:ZL 200910153240.4,专利申请日:20091029,授权公告日:2011914

4方群,张婷,杜文斌,刘军,一种用于毛细管电泳的微体积试样引入装置及其使用方法,中国发明专利,专利号:ZL 200610052734.X,专利申请日:200681,授权公告日:201016

5方群,杜文斌,何巧红,微分析芯片的高通量连续换样装置及其使用方法,中国发明专利,专利号:ZL 200410016224.8,专利申请日:200429,授权公告日:2009520

6方群,何巧红,自动液体更换的微流控芯片毛细管电泳分析装置及其使用方法,中国发明专利,专利号:ZL 200610050805.2,专利申请日:2006518,授权公告日:2009610

7方群,李丹妮,陈宏,微分析芯片贮液池内的液位稳定装置及其使用方法,中国发明专利,专利号:ZL 03115485.9,专利申请日:2003219,授权公告日:2008521

8方群,富景林,黄艳贞,一种用于微分析芯片的正交光路型荧光检测装置,中国发明专利,专利号:ZL03141572.5,专利申请日:200378,授权公告日:20061122

9方群,贾志舰,方肇伦,玻璃基质微分析芯片的低温封接方法,中国发明专利,专利号:ZL 200410016216.3,专利申请日:200429,授权公告日:20061025

10方群,刘军,陈宏,微量试样浓集方法及其装置,中国发明专利,专利号:ZL 200410066752.4,专利申请日:2004924;授权公告日:2006823

11方群,曹小丹,毛细管电泳的样品引入装置和进样方法,中国发明专利,专利号:ZL 03142164.4,专利申请日:200388;授权公告日:2006712

12方群,蔡增轩,夹膜型液液萃取微分析芯片及其封接方法,中国发明专利,专利号:ZL 200410017735.1,专利申请日:2004414;授权公告日:200638

13方群,杜文斌,方肇伦,吸收光度检测的微分析芯片及其使用方法,中国发明专利,专利号:ZL03114734.8,专利申请日:200313;授权公告日:2005824

14方群,一种用于微分析芯片液体引入的装置,中国发明专利,专利号:Zl01126088.2,专利申请日:200182;授权公告日:20041020