陈军教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 476

 

陈军教授

 

个人简历

19809-19847     武汉大学生物系,学士学位

1987,12-19894     获加拿大国际发展研究中心奖学金,Saskatchewan大学作物科学系硕士生(中断)

199110-19949    中国农科院研究生院,硕士学位

19991-20048     获新加坡分子细胞生物研究院奖学金,新加坡国立大学生物学系,博士学位

 

主要科研工作经历

19848-198712:    中国农科院油料所,实习研究员,从事油菜生物技术与育种研究工作。

198712-19894:    获加拿大国际发展研究中心硕士奖学金,在加拿大Saskatoon 农业研究站从事油菜细胞与组织培养研究工作。

1989, 7-1991, 9:     中国农科院油料所,实习研究员,从事油菜生物技术与育种研究工作。

1991, 10-1994, 9:    中国科学院遗传所,硕士生,从事转基因油菜研究工作。

1994, 10-1998, 12:   中国农科院油料所,助理研究员,从事油菜生物技术与育种研究工作。两篇第一作者论文分别发表在遗传学报激光生物学报上。

19991-20048:     新加坡分子细胞生物研究院,Junior Research Fellow,从事植物病毒繁殖以及致病分子机理研究。

20049-20083:     新加坡分子细胞生物研究院  Research Fellow,从研究植物转向研究斑马鱼内皮层器官发育。。

20084-2008,12:      新加坡分子细胞生物研究院 Research Scientist,由于发现p53异构体∆113p53,从研究发育转向研究p53信号途径。

2009,1-现在:浙江大学生命科学院,教授, 1:利用模式系统斑马鱼和人类细胞系研究p53及其异构体在发育再生和癌症治疗中的作用;2:利用斑马鱼,建立新的成体遗传筛选体系,筛选器官再生突变体,以及建立疾病模型。

 

申请人主要论文(*为通信作者)

1.    Hui Shi, Ting Tao, Delai Huang, Zhao Ou, Jun Chen, and Jinrong Peng. A naturally occurring 4-bp deletion in the intron 4 of p53 creates a spectrum of novel p53 isoforms with anti-apoptosis function. Nuclear Acid Research 43(2): 1044-1055. Jan, 2015

2.    Gong L., Gong H.J., Chang C.Q., Ou Z., Ye Y.F., Yin L., Yang L.N., Tao T., Zhang Z.H., Liu C., Lane P.D., Peng J.R., Chen J*. (2014) p53 isoform Δ113p53/Δ133p53 promotes double-strand break repair to protect cell from death and senescence in response to DNA damane. Cell Research. 已接受。

3.    Ou Z., Yin L., Chang C.Q., Peng J.R., and Chen J.*. (2014) Protein interaction between p53 and Δ113p53 is required for anti-apoptotic function of Δ113p53. Journal of Genetics and Genomics 41:53-62,2014. 封面论文

4.    Ting Tao, Hui Shi, Yihong Guan, Delai Huang, Ye Chen, David P Lane, Jun Chen*, Jinrong Peng* Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation. Cell Research 23:620-634 2013. 封面论文

5.    Wu T, Zhang Z, Yuan Z, Lo LJ, Chen Jun, et al. Distinctive Genes Determine Different Intramuscular Fat and Muscle Fiber Ratios of the longissimus dorsi Muscles in Jinhua and Landrace Pigs. PLoS ONE 8(1): e53181. 2013

6.    Hui Yang, Changwei Liu, Joonas Jamsen, Zhenxing Wu, Yingjie Wang, Jun Chen, Li Zheng and Binghui Shen. The DNase domain-containing protein TATDN1 plays an important role in chromosomal segregation and cell cycle progression during zebrafish eye development. Cell Cycle 11:24, 4626–4632. 2012

7.    Liu JG, Gong L, Chang CQ, Liu C., Peng JR, Chen Jun* Development of novel visual-plus quantitative analysis systems for studying DNA double-strand break repairs in zebrafish. Journal of Genetics and Genomics. 39:489-502. 2012

8.    Chang, C.Q., Hu, M.J., Zhu, Z.H., Lo, L.J., Chen J. and Peng, J.R. liver-enriched gene 1a and 1b encode novel secretory proteins essential for normal liver development in Zebrafish. PLoS ONE 6(8):e22910. 2011

9.    Chen J.*, and Peng J.R.* (2009) p53 isoform delta113p53 in zebrafish. ZEBRAFISH (Special Issue on Cancer Biology) 6:389-395

10.  Chen J, Ng SM, Chang C, Zhang Z, Bourdon JC, Lane DP, Peng J. p53 Isoform delta113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish. GENES & DEVELOPMENT 23(3):278-90. FEB  2009. 封面专评论文

11.  Meng CY, Chen J, Ding SW, Peng JR, and Wong SM. Hibiscus chlorotic ringspot virus coat protein inhibits trans-acting small interfering RNA biogenesis in Arabidopsis. JOURNAL OF GENERAL VIROLOGY 89: 2349 - 2358 SEP  2008

12.  Liu Y, Du L, Osato M, Teo EH, Qian F, Jin H, Zhen F, Xu J, Guo L, Huang H, Chen J, Geisler R, Jiang YJ, Peng J, Wen Z. The zebrafish udu gene encodes a novel nuclear factor and is essential for primitive erythroid cell development. BLOOD 110(1):99-106 JUL 2007

13.  Meng C, Chen J, Peng J, Wong SM. Host-induced avirulence of hibiscus chlorotic ringspot virus mutants correlates with reduced gene-silencing suppression activity. JOURNAL OF GENERAL VIROLOGY 87: 451-459 Part 2 FEB 2006

14.  Chen J, Ruan H, Ng SM, Gao C, Soo HM, Wu W, Zhang Z, Wen Z, Lane DP, Peng J. Loss of function of def selectively up-regulates Delta 113p53 expression to arrest expansion growth of digestive organs in zebrafish. GENES & DEVELOPMENT 19 (23): 2900-2911 DEC 2005

15.  Chen J, Li WX, Xie D, Peng JR, Ding SW. Viral virulence protein suppresses RNA silencing-mediated defense but upregulates the role of MicroRNA in host gene expression. PLANT CELL 16 (5): 1302-1313 MAY 2004

16.  Zeng L, Yin Z, Chen J, Leung H, Wang GL. Fine genetic mapping and physical delimitation of the lesion mimic gene Spl11 to a 160-kb DNA segment of the rice genome. MOL GENET GENOMICS. 2002 Oct;268(2):253-61.

17.  Yin Z, Chen J, Zeng L, Goh M, Leung H, Khush GS, Wang GL. Characterizing rice lesion mimic mutants and identifying a mutant with broad-spectrum resistance to rice blast and bacterial blight. MOL PLANT MICROBE INTERACT. 2000 Aug;13(8):869-76.