肖卫华教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 391

 

肖卫华博士

中国科学技术大学生命科学院教授

办公地点:生命科学院641

电话:0551-63600535

Email: xiaow@ustc.edu.cn

实验室网站: http://lstt.ustc.edu.cn

 

教育背景

1985 白求恩医科大学临床医学学士

2001美国马里兰大学(University of Maryland at Baltimore)生物信息学理学硕士

2005吉林大学内科博士

 

工作经历

1985-1995 长春生物制品研究所助理研究员

1995-1998 美国马里兰大学肿瘤研究中心博士后

1998-2005美国国立卫生研究院肿瘤研究所(NIH, NCI) 研究员(Scienctist)

2005-至今中国科学技术大学生命科学院教授

 

学术奖项与活动

2002 Research Excellence AwardNIH, NCI

2005 国家自然科学基金委员会海外青年学者合作研究基金(杰青B类)

2011-present Council member, World Immunotherapy Council

研究方向

分子肿瘤和分子免疫学: 肿瘤细胞复杂信号网络异常及基因调控机制和作用;免疫与肿瘤的相互作用及肿瘤的免疫逃逸;

生物技术及药物的研究开发:免役调节生物技术药物的研究和开发;医药生物技术的研究。

 

 

The major research goals are: (1) to elucidate the underlying mechanisms and interplays among signaling pathways and gene transcription in cancer; (2) understand molecular alterations in signaling during pathogenesis of human diseases such as cancer; (3) Study and development of biotechnology and drugs.

 

主持的课题

 

   国家自然科学基金面上项目,E2F1与细胞信号通路相互作用的分子机制及在前列腺肿瘤中的作用(20111-201312月)负责人

   国家自然基金重大科学计划培育项目,非可控性炎症恶性转化的调控网络及其分子机制(20111-201312月)负责人

   国家自然科学基金面上项目,化疗诱导IL-33对肿瘤治疗的影响和机制研究(20131-201612月)负责人

   国家重大科学计划项目,纳米分辨完整细胞三维成像的新理论和新方法(20111-201512月)骨干成员

   国家重大科学计划项目,肝脏造血免疫组织发育分化的分子调控(20131-201712月)骨干成员

 

代表性论文

   NK cells in immunotolerant organs. Sun H, Sun C, Tian Z, Xiao W. Cell Mol Immunol. 2013 May;10(3):202-12.

   NK cell-based immunotherapy for malignant diseases. Cheng M, Chen Y, Xiao W, Sun R, Tian Z. Cell Mol Immunol. 2013 May;10(3):230-52.

   Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis. Nallar SC, Kalakonda S, Lindner DJ, Lorenz RR, Lamarre E, Weihua X, Kalvakolanu DV. J Biol Chem. 2013 Mar 15;288(11):7930-41.

   Synergistic cytotoxicity of ex vivo expanded natural killer cells in combination with monoclonal antibody drugs against cancer cells. Deng X, Terunuma H, Nieda M, Xiao W, Nicol A. Int Immunopharmacol. 2012 Dec;14(4):593-605.

   Production and characterization of recombinant 9 and 15 kDa granulysin by fed-batch fermentation in Pichia pastoris. Guo Y, Luan G, Shen G, Wu L, Jia H, Zhong Y, Li R, Li G, Shen Y, Sun J, Hu S, Xiao W. Appl Microbiol Biotechnol. 2012 Dec 7. [Epub ahead of print]

   Purification and characterization of human IL-10/Fc fusion protein expressed in Pichia pastoris.Guo Y, Kang W, Zhong Y, Li R, Li G, Shen Y, Hu S, Sun J, Xiao W. Protein Expr Purif. 2012 Jun;83(2):152-6.

   Significance of E-cadherin, β-catenin, and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma. Cheng Y, Zhou Y, Jiang W, Yang X, Zhu J, Feng D, Wei Y, Li M, Yao F, Hu W, Xiao W, Ling B. Hum. Pathol. 2012 Aug;43(8):1213-20.

   Defining the Critical Hurdles in Cancer Immunotherapy. Fox BA, et al. J Transl Med. 2011 Dec 14;9(1):214.

   Ma Y, Cheng Q, Ren Z, Xu L, Zhao Y, Sun J, Hu S, Xiao W. Induction of IGF-1R expression by EGR-1 facilitates the growth of prostate cancer cells. Cancer Lett. 2012 Apr 28;317(2):150-6.

   Zhou Y, Wei Y, Zhu J, Wang Q, Bao L, Ma Y, Chen Y, Feng D, Zhang A, Sun J, Nallar SC, Shen K, Kalvakolanu DV, Xiao W, Ling B. GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers. PLoS One. 2011;6(7):e22065.

   Zhou Y, Xu Q, Ling B, Xiao W, Liu P. Reduced expression of ΔΝp63α in cervical squamous cell carcinoma. Clin Invest Med. 2011 Jun 1;34(3):E184-91.

   Hofmann ER, Nallar SC, Lin L, D'Cunha J, Lindner DJ, Weihua X, Kalvakolanu DV. Identification and characterization of GRIM-1, a cell-death-associated gene product. J Cell Sci. 2010 Aug 15;123(Pt 16):2781-91.

   Fang F, Wang Y, Li R, Zhao Y, Guo Y, Jiang M, Sun J, Ma Y, Ren Z, Tian Z, Wei  F, Yang D, Xiao W. Transcription factor E2F1 suppresses dendritic cell maturation. J Immunol. 2010 Jun 1;184(11):6084-91.

   Ma J, Ren Z, Ma Y, Xu L, Zhao Y, Zheng C, Fang Y, Xue T, Sun B, Xiao W. Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy. J Biol Chem. 2009 Dec 11;284(50):34600-6.

   Zheng C, Ren Z, Wang H, Zhang W, Kalvakolanu DV, Tian Z, Xiao W. E2F1 Induces tumor cell survival via nuclear factor-kappaB-dependent induction of EGR1 transcription in prostate cancer cells. Cancer Res. 2009 Mar 15;69(6):2324-31.

   Xiao W. Advances in NF-kappaB signaling transduction and transcription. Cell Mol Immunol. 2004 Dec;1(6):425-35. Review.

   Xiao W, Hodge DR, Wang L, Yang X, Zhang X, Farrar WL. NF-kappaB activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NFkappaB regulatory site in autocrine human multiple myeloma cells. Cancer Biol Ther. 2004 Oct;3(10):1007-17. Epub 2004 Oct 2.

   Xiao W, Hodge DR, Wang L, Yang X, Zhang X, Farrar WL. Co-operative functions between nuclear factors NFkappaB and CCAT/enhancer-binding protein-beta (C/EBP-beta) regulate the IL-6 promoter in autocrine human prostate cancer cells. Prostate. 2004 Dec 1;61(4):354-70.

   Wang LH, Yang XY, Zhang X, Huang J, Hou J, Li J, Xiong H, Mihalic K, Zhu H, Xiao W, Farrar WL. Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells. Immunity. 2004 Feb;20(2):205-18.

   Wang LH, Yang XY, Zhang X, Mihalic K, Fan YX, Xiao W, Howard OM, Appella E, Maynard AT, Farrar WL. Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor. Nat Med. 2004 Jan;10(1):40-7.

   Xiao W, Wang L, Yang X, Chen T, Hodge D, Johnson PF, Farrar W. CCAAT/enhancer-binding protein beta mediates interferon-gamma-induced p48 (ISGF3-gamma ) gene transcription in human monocytic cells. J Biol Chem. 2001 Jun 29;276(26):23275-81.

   Weihua X, Hu J, Roy SK, Mannino SB, Kalvakolanu DV. Interleukin-6 modulates interferon-regulated gene expression by inducing the ISGF3 gamma gene using CCAAT/enhancer binding protein-beta(C/EBP-beta). Biochim Biophys Acta. 2000 Jun 21;1492(1):163-71.

   Weihua X, Ling W, Kalvakolanu DV. Regulation of interferon-alpha/beta-stimulated gene expression through the gamma-activated transcriptional element. Antiviral Res. 1999 Jan;40(3):145-53.

   Weihua X, Ramanujam S, Lindner DJ, Kudaravalli RD, Freund R, Kalvakolanu DV. The polyoma virus T antigen interferes with interferon-inducible gene expression. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1085-90.

   Weihua X, Lindner DJ, Kalvakolanu DV. The interferon-inducible murine p48 (ISGF3gamma) gene is regulated by protooncogene c-myc. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7227-32.

   Weihua X, Kolla V, Kalvakolanu DV. Interferon gamma-induced transcription of  the murine ISGF3gamma (p48) gene is mediated by novel factors. Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):103-8.