戈宝学教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 951

 

Bao-Xue Ge, Ph.D.

 

PRESENT TITLE AND AFFLIATION

Professor, TongjiUniversitySchool of Medicine, Shanghai, China

Director, Shanghai Key Lab of Tuberculosis, ShanghaiChina

Director, Clinical and TranslationalResearchCenter, TongjiUniversity affiliated Shanghai Pulmonary Hospital, China

 

EDUCATION

Degree-Granting Education

1987. B.Sc. in Entomology, BeijingAgricultureUniversity, Beijing, China

1999. Ph.D. in Genetics, University of California, Riverside, California, USAMentor: Dr. Brian Federici

Postgraduate Training

3/1999-8/2002 Postdoctoral Fellow, Department of Immunology, The Scripps Research   Institute Mentor: Dr. Jiahuai Han,

8/2002-6/2005 Postdoctoral Fellow/Visiting Scholar, Department of Molecular and Cellular     Biology, HarvardUniversityMentor: Dr. Jack Strominger

 

HONORS AND AWARDS

2002      Research Fellowship Award, National Institute of Health, USA

2002      “One-Hundred Talent Program” CAS, China

2005      National Distinguished Young Scientist, NSFC, China

2006      Excellent Award, "One-Hundred Talent Program" Final Evaluation, CAS

2008      1st Tanjiazhen “Science Innovator” Award

2008      Mingzhi “Outstanding Scientist” Award

2012      Shanghai Subject Leader

2013      Excellent Graduate Advisor, CAS

 

EDITORIAL BOARDS:

2009 -: Member of Editorial Board of Microbes & Infection (Institute Pasteur, France)

Reviewer Responsibilities:

PLoS pathogens, Oncogene, JBC, Cell Research, Immunology

 

PUBLICATION LIST: (*Corresponding author):

1.    Yang H, Liu HP, Weng D, Ge B*. 2014 IL-10 negatively regulates oxLDL-P38 pathway inhibited macrophage emigration. Exp Mol Pathol. 97(3):590-9.

2.    Cui Z, Li Y, Cheng S, Yang H, Lu J, Hu Z, Ge B*. 2014 Mutations in the embC-embA region contribute to M. tuberculosis resistance to ethambutol. Antimicrobial Agents and Chemotherapy 58(11):6837-43.

3.    Zheng R, Zhu C, Guo Q, Qin L, Wang J, Lu J, Cui H, Cui Z, Ge B, Liu J, Hu Z. 2014 Pyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patients. BMC Infect Dis. 14(1):200.

4.    Bai W, Liu H, Ji Q, Zhou Y, Liang L, Zheng R, Chen J, Liu Z, Yang H, Zhang P, Kaufmann SH, Ge B*. 2014 TLR3 regulates mycobacterial RNA-induced IL-10 production through the PI3K/AKT signaling pathway. Cell Signal. 26(5):942-50.

5.    Liu F, Luo LJ, Zou QL, Zhao YX, Ratni Saini R, Han SF, Knölker HJ, Wang LS, Ge B.* 2013 Nuclear Hormone Receptor Regulation of MicroRNAs Controls Innate Immune Responses in C. elegans. PLoS Pathogens, 9(8):e1003545

6.    Yan D, Quan H, Wang L, Liu F, Liu H, Chen J, Cao X, Ge B*. 2013 Enteropathogenic Escherichia coli Tir recruits cellular SHP-2 through ITIM motifs to suppress host immune response. Cell Signal. 25(9):1887-94.

7.    Liu H, Liu Z, Chen J, Chen L, He X, Zheng R, Yang H, Song P, Weng D, Hu H, Fan L, Xiao H, Kaufmann SH, Ernst J, Ge B*. 2013 Induction of CCL8/MCP-2 by mycobacteria through the activation of TLR2/PI3K/Akt signaling pathway. PLoS One. 8(2):e56815.

8.    Xu A, Shi G, Liu F, Ge B*. 2013 Caenorhabditis elegans mom-4 is required for the activation of the p38 MAPK signaling pathway in the response to Pseudomonas aeruginosa infection. Protein Cell. 4(1):53-61.

9.    Liu S, Zhang H, Li M, Hu D, Li C, Ge B, Jin B, Fan Z. 2013 Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells. Cell Death Differ.  20(3):456-64.

10.  Yan DP, Wang X., Li-Jun Luo LJ, Xuetao Cao X. and Ge B.* 2012 Inhibition of toll-like receptor signaling by an ITIM-containing bacterial protein Nature Immunology, 13(11):1063-71

11.  Luo LJ, Liu F, Wang XY, Dai TY, Dai YL, Dong C, Ge B.* 2012 An essential function for MKP5 in the formation of oxidized low density lipid-induced foam cells. Cell Signal. 24(10):1889-1898

12.  Meng S, Zhang M, Pan W, Li Z, Anderson DH, Zhang S, Ge B, Wang C. 2012 Tyrosines 303/343/353 within the Sprouty-related domain of Spred2 are essential for its interaction with p85 and inhibitory effect on Ras/ERK activation. Int J Biochem Cell Biol. 2012 44(5):748-58.

13.  Bian J, Wang K, Kong X, Liu H, Chen F, Hu M, Zhang X, Jiao X, Ge B, Wu Y, Meng S. 2011 Caspase- and p38-MAPK-dependent induction of apoptosis in A549 lung cancer cells by Newcastle disease virus. Arch Virol. 156(8):1335-44.

14.  Liu HPYu MCGe B*  2011 Supervillin associates with KIR2DL1 and regulates the cytotoxicity of natural killer cells. Cell Signal. 23(2):487-96

15.  Sun SX, Ge B, Miao CH. 2011 Effects of preconditioning with sevoflurane on TNF-α-induced permeability and activation of p38 MAPK in rat pulmonary microvascular endothelial cells. Cell Biochem Biophys. 61(1):123-9.

16.  Deng YQ, Dai JX, Ji GH, Jiang T, Wang HJ, Yang HO, Tan WL, Liu R, Yu M, Ge B, Zhu QY, Qin ED, Guo YJ, Qin CF. 2011 A broadly flavivirus cross-neutralizing monoclonal antibody that recognizes a novel epitope within the fusion loop of E protein. PLoS One. 6(1):e16059.

17.  Zhu QY, Liu Q, Chen JX, Miao C and Ge B* 2010 MicroRNA-101 targets MKP-1 to regulate the activation of MAP kinases in macrophages. J Immunol. 185(12):7435-42

18.  Meng S, Gui Q, Xu Q, Lu K, Jiao X, Fan J, Ge B, Ke Y, Zhang S, Wu J, Wang C. 2010 Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation. J Mol Cell Biol. 22(4):223-30.

19.  Qian G, Qin X, Zang YQ, Ge B, Guo TB, Wan B, Fang L, Zhang JZ. 2010 High doses of alpha-galactosylceramide potentiate experimental autoimmune encephalomyelitis by directly enhancing Th17 response. Cell Res. 20(4):480-91.

20.  Kong L, Zhang H, Qin L, Zhuang ZH, Sun L, Yu MC, Zhu J, Chen Z. Wang ZG and Ge B* 2009 An essential role for RIG-I in Toll-like receptor-mediated phagocytosis. Cell Host & Microbe 6(2):150-161. (Cited by “Faculty of 1000 Biology, Highlighted by Nature China)

21.  Cui G, Qin X, Zhang Y, Gong Z, Ge B, Zang YQ. 2009 Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice. J Biol Chem. 284(41):28420-9.

22.  Huang Z, Yan DP, Ge B* 2008 JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin. Cell Signal. 20(11):2002-12.

23.  Yu MC, Su LL, Zou L, Liu Y, Wu N, Kong L, Zhuang ZH, Sun L, Liu HP, Hu JH, Li D, Strominger JL, Zang JW, Pei G, Ge B.* 2008 An essential function for β-arrestin 2 in the inhibitory signaling of Natural Killer cells. Nature Immunology, 9(8):898-907. (Commented in Nature Immunology, Highlighted by Nature China)

24.  Zhang NN, Shen SH, Jiang LJ, Zhang W, Zhang HX, Sun YP, Li XY, Huang QH, Ge B, Chen SJ, Wang ZG, Chen Z, Zhu J. 2008 RIG-I plays a critical role in negatively regulating granulocytic proliferation. Proc Natl Acad Sci U S A. 105(30):10553-8.

25.  Kong L, Ge B*. 2008 MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis. Cell Res. 18(7):745-55 (Cover Story)

26.  Liu J, Wang ZT, Ge B. 2008 Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways. Int Immunopharmacol. 8(7):951-958.

27.  Sun L, Yu MC, Kong L, Zhuang ZH, Hu JH, Ge B*. 2008 Molecular identification and functional characterization of a Drosophila dual-specificity phosphatase DMKP-4 which is involved in PGN-induced activation of the JNK pathway. Cell Signal. 20(7):1329-1337.

28.  Li C, Ge B, Nicotra M, Stern JN, Kopcow HD, Chen X, Strominger JL. 2008 JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity. Proc Natl Acad Sci U S A. 105(8):3017-22.

29.  Chen X, Trivedi PP, Ge B, Krzewski K, Strominger JL. 2007 Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity. Proc Natl Acad Sci U S A. 104(15):6329-34.

30.  Hu JH, Chen T, Zhuang ZH, Kong L., Yu MC, Liu Y, Zang JW and Ge B*. 2007 Feedback control of MKP-1 expression by p38. Cell Signal. 19(2):393-400.

31.  Liu J, Wang ZT, Ji LL, Ge B. 2007 Inhibitory effects of neoandrographolide on nitric oxide and prostaglandin E(2) production in LPS-stimulated murine macrophage. Mol Cell Biochem. 298(1-2):49-57.

32.  Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge B*. 2006 Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli. Cell Signal. 18(4):441-8.

33.  Zhuang ZH, Sun L, Kong L, Hu JH, Yu MC, Reinach P, Zang JW, Ge B* 2006 Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB. Cell Signal. 18(7):964-70.

34.  Chen X, Allan DS, Krzewski K, Ge B, Kopcow H, Strominger JL 2006 CD28-stimulated ERK2 phosphorylation is required for polarization of the microtubule organizing center and granules in YTS NK cells. Proc Natl Acad Sci U S A. 103, 10346-10351

35.  Qin LH, Long L, Shi GJ1, Wang ZT, Ge B* 2006 Andrographolide Inhibits the Production of TNF-α and Interleukin-12 in Lipopolysaccharide-stimulated Macrophages: Role of Mitogen-Activated Protein Kinases. Biol Pharm Bull. 29:220-4.

36.  Kopcow HD, Allan DS, Chen X, Rybalov B, Andzelm MM, Ge B, Strominger JL 2005 Human decidual NK cells form immature activating synapses and are not cytotoxic. Proc Natl Acad Sci U S A. 102:15563-8.

37.  Ge B, Xiong X, Jing Q, Mosley JL, Filose A, Bian D, Huang S, Han J. 2003. TAB1beta, a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. J Biol Chem 278: 2286-2293

38.  Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J. 2002. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science 295:1291-4

39.  New L, Li Y, Ge B, Zhong H, Mansbridge J, Liu K, Han J. 2001. SB203580 promotes EGF-stimulated early morphological differentiation in PC12 cell through activating ERK pathway. J Cell Biochem. 83:585-96.

40.  Kuzina LV, Miller ED, Ge B, Miller TA. 2002. Transformation of Enterobacter gergoviae isolated from pink bollworm (Lepidoptera: Gelechiidae) gut with Bacillus thuringiensis toxin. Curr Microbiol 44:1-4

41.  Park HW, Ge B, Bauer LS, Federici BA. 1998. Optimization of Cry3A yields in Bacillus thuringiensis by use of sporulation-dependent promoters in combination with the STAB-SD mRNA sequence. Appl Environ Microbiol 64:3932-8

42.  Ge B, Bideshi D, Moar WJ, Federici BA. 1998. Differential effects of helper proteins encoded by the cry2A and cry11A operons on the formation of Cry2A inclusions in Bacillus thuringiensis. FEMS Microbiol Lett 165:35-41

43.  Bideshi DK, Hice RH, Ge B, Federici BA. 1998. Molecular characterization and expression of the Trichoplusia ni granulovirus helicase gene. J Gen Virol 79:1309-19