朱永群教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 505

朱永群

浙江大学生命科学研究院, 教授、博士生导师

国家自然科学基金委优秀青年科学基金获得者

浙江省杰出青年科学基金获得者

杭州市余杭塘路866号浙江大学医学院科研楼A201, 邮编:310058

邮箱:zhuyongqun@zju.edu.cn  

电话:0571-88206122

教育与工作背景

2012-至今浙江大学生命科学研究院教授,博士生导师

2010-2012美国霍华德-休斯医学研究所/斯隆-凯特琳癌症研究中心研究员

2007-2010北京生命科学研究所博士后

2002-2007中国科学院生物物理研究所生物化学与分子生物学博士

1998-2002南开大学生物物理学学士

代表性研究论文:

1.  Jin-Gen Xu, Chunfeng Huang, Zhengfeng Yang, Mengmeng Jin, Panhan Fu, Ni  Zhang, Jian Luo, Dali Li, Mingyao Liu, Yan Zhou and Yongqun Zhu. Crystal Structure of LGR4-Rspo1 complex: Insights  into the Divergent Mechanisms of Ligand Recognition by LGR Receptors. J Biol  Chem. 2014 Dec 5. [Epub ahead of print]


2. Yan  Zhou and Yongqun Zhu. Diversity of  bacterial manipulation of the host ubiquitin pathways. Cellular Microbiology.  Epub 2014 Nov 22.


3.  Panhan Fu, Xiaoqing Zhang, Mengmeng Jin, Li Xu, Chong Wang, Zongping Xia, Yongqun Zhu. Complex Structure of  OspI and Ubc13: The Molecular Basis of Ubc13 Deamidation and Convergence of  Bacterial and Host E2 Recognition. PLOS Pathogens. 2013 Apr.


4. Na  Dong*, Yongqun Zhu*#, Qiuhe Lu,  Liyan Hu, Yuqing Zheng, Feng Shao#.Structurally Distinct Bacterial TBC-like  GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses. Cell.  2012 Aug 31;150(5):1029-41. (* equal contribution, #共同通讯作者)


5. Yongqun Zhu, Hongtao Li,Chengzu Long,  Liyan Hu, Hao Xu, Liping Liu, She Chen, Da-Cheng Wang, and Feng Shao.  Structural Insights into the Enzymatic Mechanism of the Pathogenic MAPK  Phosphothreonine Lyase. Molecular Cell. 28, 899–913, Dec 14, 2007.


6. Yongqun Zhu, Hongtao Li, Jiayi Wang,  Liyan Hu, Yan Zhou, Liping Liu, Feng Shao. Structure of a Shigella effector  reveals a new class of ubiquitin ligases. Nature Structural & Molecular  Biology. 15(12):1302-8, Dec 2008.  


7. Yongqun Zhu, Liyan Hu, Yan Zhou, Qing  Yao, and Feng Shao. Structural mechanism of host Rab1 activation by the  bifunctional Legionella type IV effector SidM/DrrA. Proc Natl Acad Sci USA.  2010 Mar 9; 107(10):4699-704.


8.  Qing Yao, Jixin Cui, Yongqun Zhu,  Guolun Wang, Liyan Hu, Chengzu Long, Ran Cao, Xinqi Liu, Niu Huang, She Chen,  Liping Liu, and Feng Shao. A bacterial type III effector family uses the  papain-like hydrolytic activity to arrest the host cell cycle. Proc Natl Acad  Sci USA. 2009 Mar 10; 106(10):3716-21.


9. Yong-Qun Zhu, De-Yu Zhu, Lei Yin,  Ying Zhang, Clemens Vonrhein, and Da-Cheng Wang. Crystal Structure of Human  Spermidine/Spermine N1-Acetyltransferase (hSSAT): The First Structure of a  New Sequence Family of Transferase Homologous Superfamily. PROTEINS.  63:1127–1131, 2006.


10.  De-Yu Zhu, Yong-Qun Zhu*, Ren-Huai  Huang, Ye Xiang, Na Yang, Hong-Xia Lu, Gen-Pei Li, Qi Jin, and Da-Cheng Wang.  Crystal Structure of the Copper Homeostasis Protein (CutCm) from Shigella  flexneri at 1.7? Resolution: The First Structure of a New Sequence Family of  TIM Barrels. PROTEINS.58:764–768, 2005. (* equal contribution)


11.  De-Yu Zhu, Yong-Qun Zhu*, Ye Xiang  and Da-Cheng Wang. Optimizing Protein Crystal Growth through Dynamic Seeding.  Acta Cryst D. (2005). 61, 772-775. (*equal contribution)


12. Yong-Qun Zhu, De-Yu Zhu, Hong-Xia Lu,  Na Yang, Gen-Pei Li, Da-Cheng Wang.

Purification  and Preliminary Crystallographic Studies of CutC, a Novel Copper Homeostasis  Protein from Shigella flexneri. Protein & Peptide Letters. 12, 823-826,  2005.