佟超教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 419

佟超

浙江大学生命科学研究院教授,博士生导师

19779月出生于内蒙古包头市

教育经历:

1995-1999:南开大学生命科学院学士

1999-2002:中国科学院动物研究所硕士

2002-2006:美国德克萨斯大学西南医学中心(UTSW)博士

工作经历:

2006-2010:美国贝勒医学院(Baylor College of Medicine)人类分子遗传学系博士后

2011-至今:浙江大学生命科学研究院教授,博士生导师

代表性论文:

1.Tian, X.J., Gala, U., Zhang, Y.P., Shang, W.N., Jaiswal, S.,  Ronza, A., Jaiswal, M., Yamamoto, S., Sandoval, H., Duraine, L., Sardiello,  M.,  Sillitoe, R., Venkatachalam, K .,  Fan, H.Y., Bellen, H.J. *, Tong, C*  (2015). A Voltage gated calcium channel regulates lysosomal fusion with  endosomes and autophagosomes and is required for neuronal homeostasis. PLOS  Bio.  In press (* co-correspondence  author)

2.Yu, J., Wu, H., Wen, Y., Liu, Y. J., Zhou, T., Ni, B., Lin, Y.,  Dong, J., Zhou, Z., Hu, Z. B.*, Guo, X. J.*, Sha, J. H.*, Tong, C*. (2015). Identification of  seven genes essential for male fertility through a genome-wide association  study of non-obstructive azoospermia and RNA interference-mediated  large-scale functional screening in Drosophila. Hum Mol Genet. in press (*  co-correspondence author)

3 Hu, Z. B.*, Li, Z.*, Yu, J.*, Tong,  C.*, Lin, Y.*, Guo, X.*, Lu, F. , Dong, J., Xia, Y., Wen, Y., Wu, H., Li,  H., Zhu, Y., Ping, Y., Chen, X., Dai, J., Jiang, Y., Pan, S., Xu, P.,  Luo, K., Du, Q., Yao, B., Liang, M., Gui,  Y., Weng, Y., Lu,H., Wang, Z., Zhang, F., Zhu, X., Yang, X., Zhang, Z., Zhao,  H., Xiong, C., Ma, H., Jin, G., Chen, F., Xu, J., Wang, X., Zhou, Z., Chen,  Z., Liu, J., Shen, H., Sha, J. H. (2014). Association analysis identifies new  risk loci for non-obstructive azoospermia in Chinese men. Nat Commun,  23;5:3857 (* co-first author)

4.Yu, C., Zhang, Y.L., Pan, W.W., Li, X.M., Wang, Z.W., Ge, Z.J.,  Zhou, J.J., Cang, Y., Tong, C.,  Sun, Q.Y., et al. (2013). CRL4 complex regulates mammalian oocyte survival  and reprogramming by activation of TET proteins. Science 342:1518-1521.

5.Tong, C., Ohyama, T.,  Tien, A.C., Rajan, A., Haueter, C.M., and Bellen, H.J. (2011). Rich regulates  target specificity of photoreceptor cells and N-cadherin trafficking in the  Drosophila visual system via Rab6. Neuron 71:447-459.

6.Jia, H., Liu, Y., Xia, R., Tong,  C., Yue, T., Jiang, J., and Jia, J. (2010). Casein kinase 2 promotes  Hedgehog signaling by regulating both smoothened and Cubitus interruptus. J  Biol Chem 285:37218-37226.

7.Chen, Y., Li, S., Tong, C.,  Zhao, Y., Wang, B., Liu, Y., Jia, J., and Jiang, J. (2010). G protein-coupled  receptor kinase 2 promotes high-level Hedgehog signaling by regulating the  active state of Smo through kinase-dependent and kinase-independent mechanisms  in Drosophila. Genes Dev 24:2054-2067.

8.Bellen, H.J., Tong, C.,  and Tsuda, H. (2010). 100 years of Drosophila research and its impact on  vertebrate neuroscience: a history lesson for the future. Nat Rev Neurosci  11:514-522.

9.Tsuda, H., Han, S.M., Yang, Y., Tong, C., Lin, Y.Q., Mohan, K., Haueter, C., Zoghbi, A., Harati,  Y., Kwan, J., et al. (2008). The amyotrophic lateral sclerosis 8 protein VAPB  is cleaved, secreted, and acts as a ligand for Eph receptors. Cell  133:963-977.

10.Zhao, Y.*, Tong, C.*,  and Jiang, J. (2007). Hedgehog regulates smoothened activity by inducing a  conformational switch. Nature 450:252-258. (* co-first author)

11. Zhao, Y., Tong, C.,  and Jiang, J. (2007). Transducing the Hedgehog signal across the plasma  membrane. Fly (Austin) 1:333-336.

12.Tong, C., and  Jiang, J. (2007). Using immunoprecipitation to study protein-protein  interactions in the Hedgehog-signaling pathway. Methods Mol Biol 397:215-229.

13.Zhang, W., Zhao, Y., Tong,  C., Wang, G., Wang, B., Jia, J., and Jiang, J. (2005). Hedgehog-regulated  Costal2-kinase complexes control phosphorylation and proteolytic processing  of Cubitus interruptus. Dev Cell 8:267-278.

14.Jia, J., Zhang, L., Zhang, Q., Tong, C., Wang, B., Hou, F., Amanai, K., and Jiang, J. (2005).  Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus  interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell  9:819-830.

15.Jia, J.*, Tong, C.*,  Wang, B., Luo, L., and Jiang, J. (2004). Hedgehog signalling activity of  Smoothened requires phosphorylation by protein kinase A and casein kinase I.  Nature 432:1045-1050. (* co-first author)

16.Yao, L.J., Fan, H.Y., Tong,  C., Chen, D.Y., Schatten, H., and Sun, Q.Y. (2003). Polo-like kinase-1 in  porcine oocyte meiotic maturation, fertilization and early embryonic mitosis.  Cell Mol Biol (Noisy-le-grand) 49:399-405.

17.Tong, C., Fan,  H.Y., Chen, D.Y., Song, X.F., Schatten, H., and Sun, Q.Y. (2003). Effects of  MEK inhibitor U0126 on meiotic progression in mouse oocytes: microtuble  organization, asymmetric division and metaphase II arrest. Cell Res  13:375-383.

18.Moskalenko, S., Tong,  C., Rosse, C., Mirey, G., Formstecher, E., Daviet, L., Camonis, J., and  White, M.A. (2003). Ral GTPases regulate exocyst assembly through dual  subunit interactions. J Biol Chem 278:51743-51748.

19.Jia, J., Tong, C.,  and Jiang, J. (2003). Smoothened transduces Hedgehog signal by physically  interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev  17:2709-2720.

20.Fan, H.Y., Tong, C.,  Teng, C.B., Lian, L., Li, S.W., Yang, Z.M., Chen, D.Y., Schatten, H., and  Sun, Q.Y. (2003). Characterization of Polo-like kinase-1 in rat oocytes and  early embryos implies its functional roles in the regulation of meiotic  maturation, fertilization, and cleavage. Mol Reprod Dev 65:318-329.

21.Fan, H.Y., Tong, C.,  Lian, L., Li, S.W., Gao, W.X., Cheng, Y., Chen, D.Y., Schatten, H., and Sun,  Q.Y. (2003). Characterization of ribosomal S6 protein kinase p90rsk during  meiotic maturation and fertilization in pig oocytes: mitogen-activated  protein kinase-associated activation and localization. Biol Reprod  68:968-977.

22.Cheng, Y., Fan, H.Y., Wen, D.C., Tong, C., Zhu, Z.Y., Lei, L., Sun, Q.Y., and Chen, D.Y. (2003). Asynchronous  cytoplast and karyoplast transplantation reveals that the cytoplasm  determines the developmental fate of the nucleus in mouse oocytes. Mol Reprod  Dev 65:278-282.

23.Tong, C., Fan,  H.Y., Lian, L., Li, S.W., Chen, D.Y., Schatten, H., and Sun, Q.Y. (2002).  Polo-like kinase-1 is a pivotal regulator of microtubule assembly during  mouse oocyte meiotic maturation, fertilization, and early embryonic mitosis.  Biol Reprod 67:546-554.

24.Fan, H.Y., Tong, C.,  Li, M.Y., Lian, L., Chen, D.Y., Schatten, H., and Sun, Q.Y. (2002).  Translocation of the classic protein kinase C isoforms in porcine oocytes:  implications of protein kinase C involvement in the regulation of nuclear  activity and cortical granule exocytosis. Exp Cell Res 277:183-191.

25.Fan, H.Y., Li, M.Y., Tong,  C., Chen, D.Y., Xia, G.L., Song, X.F., Schatten, H., and Sun, Q.Y.  (2002). Inhibitory effects of cAMP and protein kinase C on meiotic maturation  and MAP kinase phosphorylation in porcine oocytes. Mol Reprod Dev 63:480-487.