杨巍维研究员

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 686

 

杨巍维博士

研究员,研究组长,博士生导师,国家自然科学基金“优秀青年”基金获得者

地址:上海市岳阳路320号,生物化学与细胞生物学研究所,613室,200031

电话:54921295

EMAILweiweiyang@sibcb.ac.cn

 

教育和科研经历

1997-2001:武汉大学生命科学院学士

2001-2007:中科院上海生科院健康科学研究所博士

2008-2012The University of Texas MD Anderson Cancer Center,博士后

2012-2013The University of Texas MD Anderson Cancer CenterOdyssey冠名学者

2013至今:中科院上海生科院生物化学与细胞生物学研究所,研究员,研究组长,博士生导师

获奖及荣誉

2006: 中科院上海生科院优秀学生奖

2007: 中科院院长优秀奖

2007: 中科院研究生院优秀毕业生

2011: Outstanding poster award (1st place) of Brain Tumor Center Retreat, The University of Texas MD Anderson Cancer Center

2011: Odyssey Program Outstanding Research Publication Award supported by The Health Memorial Fund, The University of Texas MD Anderson Cancer Center

2011-2012: The Thomas H. and Mayme P. Scott Fellowship in Cancer Research

2011-2012: The Harold C. and Mary L. Daily Endowment Fund

2011-2012: The Trainee of the Quarter recognition award of M.D Anderson Cancer Center

2012: Division of Cancer Medicine Research Award, The University of Texas MD Anderson Cancer Center

2013: Lupe C. Garcia Fellowship in Cancer Research

2013: US Chinese Anti-Cancer Association (USCACA) and National Foundation for Cancer Research (NFCR) Scholarship Award

承担课题

2012-2015Odyssey Fellowship, The University of Texas MD Anderson Cancer Center

2014-2018:科技部重大基础研究计划学术骨干

2015-2018:国家自然科学基金面上项目

2015-2017:国家自然科学基金优秀青年基金

研究方向

癌基因和抑癌基因的突变造成了细胞内多条信号通路的改变,从而影响肿瘤细胞的代谢,并重塑肿瘤细胞,以增强其存活和生长能力。实际上,肿瘤细胞需要改变代谢的状态来应答癌基因信号通路传递的增殖信号。除此之外,独特的生化微环境也能进一步的改变肿瘤细胞的代谢表型,从而影响肿瘤的发生、发展以及对治疗反应性。这些代谢上的顺应性(adaptation)平衡了肿瘤细胞三个最关键的需求:持续增长的能量,充足的用于合成核酸,蛋白质,脂类的生物大分子(macromolecular),以及氧化还原状态的平衡维持(redox balance)。只有充分解析这些过程才能发现肿瘤代谢通路的致命弱点,并转化为新型的癌症治疗手段。

本研究组主要研究方向是肿瘤代谢的信号转导调控。已发现糖酵解关键酶丙酮酸激酶(PKM2)的表达调控机制(Molecular Cell 2012)及细胞核内功能(Nature 2011, Cell 2012, Nature Cell Biology 2013)。实验室的有关情况介绍请参考 http://www.sibcb.ac.cn/PI.asp?id=151

发表论文

1. Jiang Y, Li X, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y, Lu Z. PKM2 regulates chromosome segregation and mitosis progression of tumor. Mol Cell. 2014 Jan 9;53(1):75-87.

2. Zheng Y, Yang W, Aldape, K, He, J, Lu, Z. Epidermal Growth Factor (EGF)-enhanced Vascular Cell Adhesion Molecule-1 (VCAM-1) Expression Promotes Macrophage and Glioblastoma Cell Interaction and Tumor Cell Invasion. J Biol Chem. 2013 Nov 1;288(44):31488-95.

3. Yang W, Lu, Z. Nuclear PKM2 regulates the Warburg effect. Cell Cycle 2013 Oct 1:12(19):3154-8

4. Yang W*, Lu, Z. Regulation and function of PKM2 in cancer. Cancer Letter 2013 Jun 18. 3835(13)00458-8. (*corresponding author)

5. Xia Y, Yang W, Bu W, Ji H, Zhao X, Zheng Y, Lin X, Li Y, Lu Z. Differential regulation of c-Jun plays an instrumental role in chemoresistance of cancer cells. J Biol Chem. 2013 Jul 5;288(27):19321-9.

6. Yang W, Zheng Y, Xia Y, Ji H, Cote G, Aldape K, Chen X, Lu. Z. ERK1/2-dependent nuclear translocation of PKM2 promotes the Warburg effect. Nat. Cell Biol. 2012 Dec;14(12):1295-304.

7. Yang W, Xia Y, Zheng Y, Bu W, Yung W, Cote G, Aldape K, Li Y, Verma I, Chiao P, Lu Z. EGFR-induced NF-kB activation upregulates PKM2 expression and promotes the Warburg effect. Mol. Cell. 2012 Dec 14;48(5):771-84..

8. Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Yung W, Lu Z. PKM2 phosphorylates Histone H3 and promotes gene transcription and tumorigenesis.Cell. 2012 Aug 17;150(4):685-96.

9. Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, and Lu Z. Nuclear PKM2 regulates -catenin transactivation upon EGF stimulation. Nature. 2011 Dec 1;480(7375):118-22..

10. Zheng Y, Yang W, Xia Y, Hawke D, Liu D, and Lu Z. Ras-induced and ERK1/2 phosphorylation-dependent isomerization of PTP-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST. Mol. Cell Biol. 2011 Nov;31(21):4258-69..

11. Yang W, Shu B, Zhu Y, Yang H. E2F6 Inhibits Cobalt Chloride-Mimetic Hypoxia-induced apoptosis through E2F1. Mol. Biol. Cell., 19(9):3691-700, 2008.

12. Yang W, Wang Z, Zhu Y, and Yang H. E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1. Cell Death Differ, 14: 807-817, 2007.

会议摘要

1.    Yang W, Xia Y, Zheng Y, Chiao P,  Lu Z. Metabolic cooperation between EGFR and NF-kappaB pathways in glioblastoma development. 102th AACR Annual Meeting; Orlando, FL, 2011.

2.    Yang W, Xia Y, Ji H, Zheng Y, Aldape K, Lu Z. Nuclear PKM2 regulates b-catenin transactivation upon EGFR activation. Keystone Symposia, Cancer and Metabolism (Q3). Banff, Canada, 2012.

3.    Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lysiotis C, Aldape K, Cantley L, Lu Z. Nuclear PKM2 promotes the Warburg effect. Keystone Symposia, Tumor Metabolism (X4), Colorado, USA, 2013

4.    Yang W, Xia Y, Ji H, Zheng Y, Chiao P, Lu Z. Growth factor-induced PKM2 upregulation. Keystone Symposia, Tumor Metabolism (X4), Colorado, USA, 2013

专著章节

1.    Yang W, Yang, H.T. Biological roles and regulatory mechanisms of transcription factor E2F6. Research Sigpost, 167-178, 2008 (ISBN: 978-81-308-0230-5)