张华凤教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 528

Huafeng Zhang, Ph. D

School of Life Science

The University of Science and Technology of China

Tel: 86-551-63607131(Lab)

Email: hzhang22@ustc.edu.cn

Education

  Oct. 2000 ~ Mar. 2004   Ph.D., Department of Pharmaceutical Science

                                            University of Tokyo, Japan

  Sep. 1997 ~ Dec.1999   M.S., Department of Pharmacology, Shenyang Pharmaceutical          

                                            University, China  

  Sep. 1992 ~ July 1997   B S., Department of Pharmacy, Shenyang Pharmaceutical

                                            University, China.

 

Employment and Appointment

      Feb. 2011 ~present

              Professor School of Life Science, the University of Science and Technology of China

    Feb. 2008~Feb. 2010

              Research Associate

              Department of Oncology, Johns Hopkins University School of Medicine

      Sep. 2005 ~ Jan. 2008  

              Postdoctoral fellow

              Department of Genetic Medicine, Johns Hopkins University School of Medicine

      Apr. 2004 ~ Aug. 2005

                Postdoctoral fellow,

                Laboratory of Protein Dynamics and Signaling, Center for Cancer Research,

              NCI-Frederick, NIH

      May 2000 ~ Sep. 2000  

                Visiting Researcher

                Institute of Molecular and Cellular Bioscience, University of Tokyo, Japan.

 

Book chapters

1. Zhang H and Semenza GL. Chapter Three: von Hippel–Lindau tumor suppressor, hypoxia-induced factor-1, and tumor vascularization In Cancer Genome and Tumor Microenvironment. ISBN: 978-1-4419-0710-3, Springer (New York), 2009

2. Sun L, He X, Cao Y, Gao P*, Zhang H*. MicroRNAs and Energy Metabolism in Cancer Cells In MicroRNAs: Key Regulators of Oncogenesis. ISBN 978-3-319-03724-0, Springer (New York), 2014

 

Awards and Honors

1. Chinese government “one thousand talents” program award in 2011

2. Chinese Academy of Science “one hundred talents” program award in 2010

3 Albert Lehninger Award --Johns Hopkins Young Investigator Awards in April, 2008.

4 IWAKI International Medical Scholarship, Japan (2001- 2003)

5 TOUKA International Student Scholarship, Japan (2000-2001)

 

Selected Publications (*corresponding author)

1.   Cao Y, Guo WT, Tian S, He X, Wang X, Liu XM, Gu K, Ma X, Huang D, Hu L, Cai YP, Zhang H, Wang YM*,Gao P*. miR-290/371-Mbd2-Myc Circuit Regulates Glycolytic Metabolism to Promote Pluripotency. EMBO J. 2015 Jan 20. pii: e201490441. [Epub ahead of print]

2.   Liu Y, Qian P, Chen C, Lu X, Sun B, Zhang X, Wang L, Gao X, Li H, Chen Z, Tang J, Zhang W, Dong J, Bai R, Lobie PE, Wu Q, Liu S, Zhang H, Zhao F, Wicha MS, Zhu T*, Zhao Y*. (2015) Gd-metallofullerenol nanomaterial nanomaterial as non-toxic cancer stem cell specific inhibitor. Nat Commun. 6,5988.

3.   Liu Z, Semenza GL, Zhang H*. Hypoxia-inducible factor-1 and breast cancer metastasis. J Zhejiang Univ Sci B. 2015 Jan;16(1):32-43.

4.   Yuan Y, Sun H, Ge S, Wang M, Zhao H, Wang L, An L, Zhang J, Zhang H, Hu B, Wang J, Liang G. Controlled Intracellular Self-Assembly and Disassembly of 19F Nanoparticles for MR Imaging of Caspase 3/7 in Zebrafish. ACS Nano. 2014 Dec 30.

5.   Zhao T, Ren H, Li J, Chen J, Zhang H, Xin W, Sun Y, Sun L, Yang Y, Sun J, Wang X, Gao S, Huang C, Zhang H, Yang S, Hao J. LASP1 Is a HIF1α Target Gene Critical for Metastasis of Pancreatic Cancer. Cancer Res. 2015 Jan 1;75(1):111-9.

6.   Ma X, Li C, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P*, Zhang H*. Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nature Communications. 2014 Oct 10;5:5212.

7. Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P and Zhang H* HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation is Critical for Cancer Progression. Cell Reports. 2014 Sep 25;8(6):1930-42.

8. Yang C, Jiang L, Zhang H, Shimoda LA, DeBerardinis RJ, Semenza GL*. Analysis of hypoxia-induced metabolic reprogramming. Methods Enzymol. 2014; 542:425-55.

9. Huang D, Li C, Zhang H*. Hypoxia and cancer cell metabolism. Acta Biochim Biophys Sin. 2014 Mar;46(3):214-9

10. He X, Cao Y, Wang L, Han Y, Zhong X, Zhou G, Cai Y, Zhang H, Gao P*. Human fibroblast reprogramming to pluripotent stem cells regulated by the miR19a/b-PTEN axis. PLoS One. 2014 Apr 16; 9(4):e95213.

11. Yang F, Zhang H, Mei Y, Wu M*. Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect. Mol Cell 2014 Jan 9;53(1):88-100.

12. Chaturvedi P, Gilkes DM, Wong CC, Kshitiz, Luo W, Zhang H, Wei H, Naoharu N, Schito L, Levchenko A, Semenza GL* Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis Journal of Clinical Investigation, 123(1), pp189-205,2013

13. Gao P*, Sun L, He X, Cao Y, Zhang H. MicroRNAs and the Warburg Effect: new players in an old arena. Curr Gene Ther.12(4):285-91,2012

14. Schito L, Rey S, Tafani M, Zhang H, Wong CC, Russo A, Russo MA, Semenza GL. Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells. PNAS 2;109 (40),2012

15. Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi ME, Semenza GL. Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. J Mol Med 90(7):803-15,2012

16. Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT Jr, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL*. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 31(14), pp1557-70, 2012

17. Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL*. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. PNAS 108(39), pp16369-74, 2011

18. Yoshida T#, Zhang H# Shen J, Semenza GL, Campochiaro P. Digoxin Inhibits Retinal Ischemia-induced HIF-1a Expression and Ocular Neovascularization FASEB J. 24(6):1759-67,2010 (#Equal Contributors)

19. Sharma P, Murillas R, Zhang H, Kuehn MR*. N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies. J Cell Sci. 15;123(Pt 8):1227-34,2010

20. Zhang H; Semenza GL. Reply to Lopez-Lazaro: Evidence that digoxin inhibits human cancer PNAS 106(9): E27-E27,2009

21. Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza, GL. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. PNAS 106(42): 17910-5,2009

22. Zhang H, Qian DZ, Tan Y, Lee K,Gao P, Ren YR,Rey S, Hammers H, Chang D,1 Pili R, Dang CV, Liu JO and Semenza GL. Digoxin and Other Cardiac Glycosides Inhibit HIF-1a Synthesis and Block Tumor Growth. PNAS 105(50):19579-86,2008

23. Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem.283(16):10892-903,2008

24. Zhang H, Semenza GL. The expanding universe of hypoxia. J Mol Med 86(7):739-46,2008

25. Liu L, Marti GP, Wei X, Zhang X, Zhang H, Liu YV, Nastai M, Semenza GL, Harmon JW. (2008) Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. J Cell Physiol. 217(2):319-27,2008

26. Zhang H., Gao P., Fukuda R., Kumar G., Krishnamachary B., Dang CV., Semenza GL. HIF-1 represses mitochondrial mass and respiration in VHL-null renal cell carcinoma. Cancer Cell 11(5):407-20,2007

27. Fukuda R, Zhang H., Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells. Cell. 129(1):111-22,2007

28. Gao P, Zhang H, Dinavahi R, Li F, Xiang Y, Raman V, Bhujwalla ZM, Felsher DW, Cheng L, Pevsner J, Lee LA, Semenza GL, Dang CV. HIF-dependent Anti-tumorigenic Effect of Anti-oxidants In Vivo. Cancer Cell. 12(3):230-8,2007

29. Liu YV, Baek JH., Zhang H., Diez R, Cole RN., Semenza GL. RACK1 competes with HSP90 for binding to HIF1alpha, and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF1alpha. Molecular Cell. 25(2):207-17,2007

30. Bosch-Marce M, Okuyama H, Wesley JB, Sarkar K, Kimura H, Liu YV, Zhang H, Strazza M, Rey S, Savino L, Zhou YF, McDonald KR, Na Y, Vandiver S, Rabi A, Shaked Y, Kerbel R, Lavallee T, Semenza GL. Effects of Aging and Hypoxia-Inducible Factor-1 Activity on Angiogenic Cell Mobilization and Recovery of Perfusion Following Limb Ischemia. Circulation Research. 101(12):1310-8,2007

31. Baek JH, Liu YV, McDonald KR, Wesley JB, Zhang H, Semenza GL. Spermidine/spermine-N1-acetyltransferase-1 binds to HIF-1alpha and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. J Biol Chem. 282 (46):33358-66,2007

32. Zhang H, A.Tomida, R. Kosimisu, Y. Ogiso, S.H. Lei and T. Tsuruo. Cullin 3 Promotes Proteasomal Degradation of Topoisomerase I-DNA Covalent Complex. Cancer Res. 2004, 64, 1114-1121,2004

33. Wu CF, Li CL, Song HR, Zhang H, Yang JY, Wang YL. Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice.  

    J. Pharm Pharmacol. 55(8): 1159-62,2003

34. Cai B, Zhang H., Zhang DY, Cui CB, Li WX. Apoptosis-inducing activity of extract from

    Chinese herb, Albizzia Licicidor I. Nielsen. Chinese J. Cancer 21(4): 373-8,2002

35. Cai B, Zhang H., Cui CB and Wang SL. A new method for identifying cell apoptosis.

    Chinese J. Cancer 21 (8): 923-6,2002

36. Wang SL, Cai B, Cui CB, Zhang H., Yao XS and Qu GX. Apoptosis induced by Caesalpinia  

      sappan L. extract in leukemia cell line K562. Chinese J. Cancer 20 (12): 1376-1379,2001