杨振业教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 495

杨振业博士

中国科学技术大学生命学院教授、博导。

地址:   安徽合肥黄山路443号中国科学技术大学生命学院,230027

Email:   zhenye@ustc.edu.cn

电话:   0551-63600613

教育经历:

1999/09-2005/07中国科学院上海生命科学研究院,生物化学与细胞生物学研究所,博士 (导师:朱学良研究员)

1995/09-1999/07上海交通大学,生命科学与技术学院,学士

研究工作经历:

2013/03-至今,中国科学技术大学,生命科学学院,教授

2010/12-2013/02 美国国立癌症研究所NCI/NIH,小鼠肿瘤遗传系,研究科学家(导师:  Terry Van Dyke博士)

2009/12-2010/11 Wadsworth研究中心, 纽约州立奥尔巴尼分校,研究科学家(导师: Conly Rieder博士)

2005/12-2009/11 Wadsworth研究中心, 纽约州立奥尔巴尼分校,博士后(导师:  Conly Rieder博士)

研究方向:

1.   细胞分裂与肿瘤的发生发展的相互调控机制

2.   抗有丝分裂化疗药物作用的分子机理

3.   肿瘤恶性发展过程中炎症和代谢的调控机制

在研项目:

1.   国家重大科学研究计划子课题:肿瘤代谢异常的关键蛋白质作用机制及其分子调控网络。

2.   国家自然科学基金委项目:  Aurora-A激酶在G2后期调控有丝分裂检查点建立和激活的机制研究。

3.   国家重点基础研究计划(973计划)子课题:免疫炎症反应与肿瘤药物治疗效果以及抗药性的关系

发表文章:

1.   Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y and Zhu X. 2012. Misfolded Gbeta2 is recruited to cytoplasmic dynein by Nudel for efficient clearance. Cell Res. 22(7):1140-54.

2.   Yang Z., Kenny A., Brito D. and Rieder C. 2009. Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments. J Cell Biol.186: 675-684.

Featured in Faculty 1000 as “Must read”

3.   Yang Z., Loncarek J., Khodjakov A. and Rieder C. 2008. Extra centrosomes and/or chromosomes prolong mitosis in human cells. Nat .Cell Biol. 10: 748-751.

Journal cover, highlighted in Cell

4.   Brito D.*, Yang Z.* and Rieder C. 2008. Microtubules do not promote mitotic slippage when the Spindle Assembly Checkpoint cannot be satisfied. J Cell Biol. 182(4):623-9. (* Co-first author)

Featured in Faculty 1000 as “Must Read”

5.   Yang Z., Tulu S., Wadsworth P. and Rieder C. 2007. Kinetochore Dynein is Required for Normal Chromosome Motion and Congression Independent of the Spindle Checkpoint. Curr. Biol. 17(11): 973-80.

Featured in Faculty 1000 as “Recommended”

6.   Liang Y., Yu W., Li Y., Yu L., Zhang Q., Wang F., Yang Z., Du J., Huang Q., Yao X., and Zhu X. 2007. Nudel Modulates Kinetochore Association and Function of Cytoplasmic Dynein in M Phase. Mol. Biol. Cell. 18 (7): 2656-66.

7.   Guo J, Yang Z, Song W, Chen Q, Wang F., Zhang Q. and Zhu X. 2006. Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. Mol. Biol. Cell. 17(2):680-9.

8.   Zhou X, Wang R, Fan L, Li Y, Ma L, Yang Z, Yu W, Jing N, Zhu X. 2005. Mitosin/cenp-F as a negative regulator of activating transcription factor-4. J Biol. Chem. 280(14): 13973-7.

9.   Yang Z., Guo J., Chen Q., Du J., Ding C., and Zhu X. 2005. Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Mol. Cell. Biol. 25: 4062-4074.

10. Liang, Y., Yu W., Li Y., Yang Z., Yan X., Huang Q., and Zhu X.. 2004. Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein. J Cell Biol. 164:557-66.

11. Yang, Z., Guo J., Li N., Qian M., Wang S, and. Zhu X. 2003. Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. Cell Res. 13:275-83.

12. Zhao, X., Yang Z., Qian M., and Zhu X. 2001. Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub. Biochem. Biophys. Res. Commun. 280:513-7.

获奖:

2008     American Society for Cell Biology 48th annual meeting travel award, San Francisco

2005     Third prize of excellent scientific paper, meeting of the Chinese Society of Cell Biology

2005     Dean’s Award, Chinese Academy of Sciences

2003     Outstanding Graduate Student Award, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences

2002     Outstanding Graduate Student Award, Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences