张龙教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 427

Long Zhang (Zhang L) Ph.D.

 

教授、博士生导师。

Address (CN): Nano building Room A575, 866 Yuhangtang Road, Hangzhou, Zhejiang Province 310058 China.

Tel: 0571-88208375 (office) 0571-88208507 (lab)

E-mail: L_Zhang@zju.edu.cn.

Address (EU): Dept. Molecular Cell Biology Building 2, Room R-02-02 Leiden

University Medical Center Postzone S-1-P Postbus 9600, 2300 RC Leiden, The Netherlands.

Tel: +31-71-526 9269 (office) Fax: +31-71- 5268270

Email: L.zhang@lumc.nl

Doctorate Department of Biological Science and Biotechnology, Tsinghua University,China. June, 2008

Work experience since graduating

August 2008 – August 2010: Post of Scientific Researcher, Leiden University

Medical Center (LUMC), The Netherland.

Sep. 2010 – May 2013: Researcher, Leiden University Medical Center (LUMC),

The Netherland.

June 2013 – Sep. 2013: Research Assistant Professor, Researcher, Leiden

University Medical Center (LUMC), The Netherland.

Sep. 2013 – present: Research Assistant Professor (Guest), Leiden University

Medical Center (LUMC), The Netherland.

Sep. 2013 – present: Professor, Life Science Institute, Zhejiang University, China

International collaborations

Collaborate internationally with

Novartis Institutes for Biomedical Research, USA.

Novartis institutes, Shanghai, China

Institute of Biology, Leiden University, The Netherland

School of Life Science, Tsinghua University, China

Chongqing medical University, China

School of Medicine, Xiamen University, China

Grants

(Joined grant) Netherlands Organization for Scientific Research (NWO

918.66.066) and Center for Biomedical Genetics. €180.000

(Joined grant) Netherlands Organization for Scientific Research (VICI

016.066.606) €845.000

(Joined grant) Centre for Biomedical Genetics on “TGF-beta signal transduction

in cancer and other diseases” €330.000

(Joined grant) Swedish Cancer Society grant on "Targeting TGF- β in breast

cancer invasion and metastasis" €180.000

Zhejiang University Special Fund for Fundamental Research and the

Fundamental Research Funds for the Central Universities. RMB5000.000

Zhejiang Provincial Natural Science Foundation of China (Grant No.

R14C070002). RMB360.000

The National Natural Science Funds of China (Grant No. 31471315). RMB

1000.000

Publications and Citations:

List of Publications:

Accepted publications:

(1) Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination.

Xie F, Zhang Z, van Dam H, Zhang L#, Zhou F#. Cells. 2014 Oct 15;3(4):981-93.

doi: 10.3390/cells3040981. Review. (#corresponding author)

(2) TRAF4 mediates activation of TGF-β signaling and is a biomarker for

oncogenesis in breast cancer.Zhou F, Li F, Xie F, Zhang Z, Huang H, Zhang L#.

Sci China Life Sci. 2014 Sep 24. (#corresponding author)

(3) Zhang J, Zhang X, Xie F, Zhang Z, van Dam H, Zhang L#, Zhou F#. The

regulation of TGF-β/SMAD signaling by protein deubiquitination. Protein

Cell. 2014 Apr 23 (#corresponding author)

(4) Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by

activating TGF-b signaling. Zhou F, Drabsch Y, Dekker T, Vinuesa A, Li Y,

Hawinkels L, Sheppard K-A, Goumans M-J, Luwor R.B, Carlie J, Wilma E,

Tollenaar R.A, Devilee P, Chris X, Zhu HJ, Zhang L# & Ten Dijke P#. Nat

Commun. 2014 (#corresponding author)

(5) Zhang L#, Zhou F Ten Dijke P. Signaling interplay between TGF-β receptor

and PI3K/AKT pathway in cancer. Trends Biochem Sci. 38(12), pp.612-20,

2013 (#corresponding author)

(6) Zhang L, Zhou F*, García de Vinuesa A, de Kruijf EM, Mesker WE, Hui L,

Drabsch Y, Li Y, Bauer A, Rousseau A, Sheppard KA, Mickanin C, Kuppen PJ,

Lu CX, Ten Dijke P*. TRAF4 Promotes TGF-β Receptor Signaling and Drives

Breast Cancer Metastasis. Mol Cell. 51(5), pp. 559-72, 2013

(7) Drabsch Y, He S, Zhang L, Snaar-Jagalska BE1, Ten Dijke P.

Transforming growth factor-

β signalling controls human breast cancer metastasis in

a zebrafish xenograft model. Breast Cancer Res. 15(6), pp. R106, 2013

(8) Zhang X, Zhang J, Bauer A, Zhang L, Selinger DW, Lu CX, and ten Dijke P*.

Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated

monoubiquitination of SMAD6. EMBO J. 32(7), pp. 996-1007, 2013

(9) Zhang X, Zhang J, Zhang L, van Dam H, Ten Dijke P*. UBE2O negatively

regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6

polyubiquitination. Cell Res. 23(3), pp. 366-77, 2013

(10) Zhang L, Zhou F, Drabsch Y, Snaar-Jagalska E, Mickanin C, Huang H,

Sheppard KA, Lu C, and ten Dijke P. USP4 is regulated by Akt phosphorylation

and directly deubiquitinates TGF-β type I receptor. Nat Cell Biol. 14(7), pp. 717-

26, 2012

(11) Zhang L#, Huang H, Zhou F, Pardo CG, Zhang T, Barakat TS, Sheppard KA,

van Dam H, Gribnau J, Lu C, and ten Dijke P#. RNF12 controls embryonic stem

cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for

degradation. Mol Cell. 46(5), pp. 650-61, 2012 (#corresponding author)

(12) Zhou F, Kai Gong, Yandao Gong and Zhang L#. APP intracellular domain

(AICD) inhibits Wnt signaling and promotes neurite outgrowth. Biochim Biophys

Acta-Molecular Cell Research. 1823(8), pp. 1233-41, 2012 (#corresponding

author)

(13) Zhang, J, Zhang X-f, Zhang L, Zhou F, van Dinther M, ten Dijke P. LRP8

mediates Wnt/β-catenin signaling and controls osteoblast differentiation. J Bone

Miner Res. 27(10), pp. 2065-74, 2012

(14) Zhang L, Zhou F, Li Y, Drabsch Y, Zhang J, van Dam H, Ten Dijke P. Fasassociated

factor 1 is a scaffold protein that promotes β-TrCP mediated β-catenin

ubiquitination and degradation. J Biol Chem. 287(36), pp. 30701-10, 2012

(15) Gong K, Zhou F, Huang HZ, Gong YD, Zhang L#. Suppression of GSK3β

by ERK mediates lipopolysaccharide induced cell migration in macrophage

through β-catenin signaling. Protein Cell. 3(10), pp. 762-8, 2012 (#corresponding

author)

(16) Zhou F, Zhang XF, van Dam H, ten Dijke P, Huang HZ, Zhang L#. Ubiquitinspecific

protease 4 mitigates Toll-like/Interleukin-1 receptor signaling and

regulates innate immune activation. J Biol Chem. 287(14), pp. 11002-10, 2012

(#corresponding author)

(17) Zhang L, Shi S, Zhang J, Zhou F, ten Dijke P. Wnt/β-catenin signaling

changes C2C12 myoblast proliferation and differentiation by inducing Id3

expression. Biochem Biophys Res Commun. 419(1), pp. 83-8, 2012

(18) Zhou F, Huang H, Zhang L# Bisindoylmaleimide I enhances osteogenic

differentiation. Protein Cell. 3(4), pp. 311-20, 2012 (#corresponding author)

(19) Guidelines for the use and interpretation of assays for monitoring autophagy.

Klionsky DJ, Abdalla FC, Abeliovich H, et al, Zhang L et al. Autophagy. 8(4), pp.

445-544, 2012

(20) Zhou F# , Zhang L#, van Laar T, van Dam H, ten Dijke P*. GSK3β

inactivation induces apoptosis of leukemia cells by repressing the function of c-

Myb. Mol Biol Cell. 22(18), pp. 3533-40, 2011 (#o-first authors)

(21) Zhang L, Zhou F, van Laar T, Zhang J, van Dam H, ten Dijke P. Fasassociated

factor 1 antagonizes Wnt signaling by promoting β-

catenin degradation. Mol Biol Cell. 22(9), pp. 1617-24, 2011

(22) Zhou F, van Laar T, Huang HZ, Zhang L#. APP and APLP1 are degradated

through autophagy in response to proteasome inhibition in neuronal cells.

Protein Cell. 2(5), pp. 377-83, 2011 (#corresponding author)

(23) Zhou F; Gong K; van Laar T; Gong Y, Zhang L#. Wnt/β-catenin signal

pathway stabilizes APP intracellular domain (AICD) and promotes its

transcriptional activity. Biochem Biophys Res Commun. 412(1), pp. 68-73,

2011 (#corresponding author)

(24) Yan X, Zhang J, Pan L, Wang P, Xue H, Zhang L, Gao X, Zhao X, Ning Y,

Chen YG*. TSC-22 promotes TGF-β-mediated cardiac myofibroblast

differentiation by antagonizing Smad7 activity. Mol Cell Biol. 31(18), pp. 3700-9,

2011

(25) Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima

M, Furuichi T, Ikegawa S, Gao X, Chen YG, Jiang D, Ning W*. Follistatin-like 1

(Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in

controlling mouse lung development. Proc Natl Acad Sci U S A. 108(17), pp.

7058-63, 2011

(26) Zhou F#, Zhang L#, Gong K, Lu G, Sheng B, Wang A, Zhao N, Zhang X,

Gong Y*. LEF-1 activates the transcription of E2F1. Biochem Biophys Res

Commun. 365(1), pp. 149-53, 2008 (#co-first authors)

(27) Zhou F#, Zhang L#, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X,

Zhao N, Gong Y*. The association of GSK3β with E2F1 facilitates nerve growth

factor-induced neural cell differentiation. J Biol Chem. 283(21), pp. 14506-15,

2008 (#co-first authors)

(28) Gao X, Wen J, Zhang L, Li X, Ning Y, Meng A, Chen YG*. Dapper1 is a

nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in

the nucleus. J Biol Chem. 283(51), pp. 35679-88, 2008

(29) Su Y#, Zhang L#, Gao X, Meng F, Wen J, Zhou H, Meng A, Chen YG*. The

evolutionally conserved activity of Dapper2 in antagonizing TGF-β signaling.

FASEB J. 21(3), pp. 682-90, 2007 (#co-first authors)

(29) Chen YG*, Wang Z, Ma J, Zhang L, Lu Z. Endofin, a FYVE domain protein,

interacts with Smad4 and facilitates transforming growth factor-β signaling. J Biol

Chem. 282(13), pp. 9688-95, 2007

(30) Zhang L, Gao X, Wen J, Ning Y, Chen YG*. Dapper 1 antagonizes Wnt

signaling by promoting dishevelled degradation. J Biol Chem. 281(13), pp. 8607-

12, 2006

(31) Gu Y, Jin P, Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG*.

Functional analysis of mutations in the kinase domain of the TGF-β receptor

ALK1 reveals different mechanisms for induction of hereditary hemorrhagic

telangiectasia. Blood. 107(5), pp. 1951-4, 2006

(32) Zhou H, Su Y, Sun Z, Zhang H, Zhang L, Zhang Y, Ning Y, Chen

YG, Meng A*. Zebrafish Dpr2 inhibits mesoderm induction by promoting

degradation of nodal receptors. Science. ;306(5693)pp. 114-7, 2004

Meeting Abstract:

(33)Long Zhang, Suping Zhang, Xia Gao, Jun Wen, Yeguang Chen. Modulation

of TGF-signaling in the cytoplasm and the nucleus. The 5th Asian-Pacific

Organization for Cell Biology Congress (APOCB 2006), Oct. 28 to 31, 2006,

Beijing , China. Published in Cell Research (2006) 16:S131-S157 (APOCB2006-

09-052, page S153)