薛天教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 1016

 

薛天,博士,

中国科学技术大学生命科学学院和微尺度国家实验室教授、博导,科技部国家重大科学研究计划青年973项目首席科学家。

教育和研究经历:

1995-2000年,中国科学技术大学少年班系(强化班),获学士学位

2000-2005年,美国约翰霍普金斯大学医学院,获分子生理学博士学位

2006-2011年,美国约翰霍普金斯大学医学院神经学系,博士后

2011-2012年,美国约翰霍普金斯大学医学院神经学系,助理研究员

2012年至今,中国科学技术大学生命科学学院和微尺度国家实验室,教授博导

 

获奖情况:

American Heart Association (AHA) 2003 Scientific Sessions Selected Late-Breaking Science         2003

NIH Stem Cells Scholarship at the Keystone Stem Cells Symposium, NIH             2004

BEST BASIC SCIENCE PAPER by Circulation, AHA (1 basic-science paper per year in Circulation)           2006

Final list of Life Science Research Foundation Fellowships (list of 60 out of 820)   2007

国家自然科学基金委优秀青年基金                                     2013

Human Frontier Science Program (HFSP)Young Investigator Grants             2014

 

发表论文:

长期从事光感受神经生物学的光信号转导和神经环路以及干细胞相关的感光细胞再生等研究。至今共发表SCI论文24篇,多篇第一或通讯作者论文发表在Nature(通讯作者)、Nature NeuroscienceCirculationCirculation ResearchStem Cells等学术期刊,引用超过1000余次。

 

1.   Hu QX, Dong JH, Du HB, Zhang DL, Ren HZ, Ma ML, Cai Y, Zhao TC, Yin XL, Yu X, Xue T, Xu ZG, Sun JP 2014 Constitutive Gαi Coupling Activity of VLGR1 and its Regulation by PDZD7. J Biol Chem 289(35):24215-2

 

2.   Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Park T, Zambidis E, Meyer J, Gamm MD, Yau KW, Canto-Soler MV (2014). Human-iPSC-Derived, 3-Dimensional Retinal Cups with Functional Photoreceptors. Nature Communications 5:4047.

 

3.   Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai SI, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, Diantonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ. (2013). Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proc Natl Acad Sci U S A. 110(10):4045-50.

 

4.   Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UFO, Benucci A, Sung CH, Carandini M, Yau KW, Sowden JC, Ali RR. (2012). Restoration of vision after transplantation of photoreceptors. Nature. 485(7396):99-103.

 

5.   Xue T?, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW?. (2011). Melanopsin Signaling in Mammalian Iris and Retina. Nature. 479(7371):67-73. (Research Article) (? co-corresponding authors); Faculty of 1000: f1000.com/13360986.

 

6.   Do MT, Kang SH, Xue T, Zhong H, Liao HW, Bergles DE, Yau KW. (2009) Photon capture and signalling by melanopsin retinal ganglion cells. Nature. 457(7227):281-7. (Research Article); Faculty of 1000: f1000.com/1144855.

 

7.   Luo DG, Xue T, Yau KW. (2008) How vision begins: An odyssey. Proc Natl Acad Sci U S A. 105(29): 9855-62 (review)

 

8.   Fu YB*, Kefalov V*, Luo DG*, Xue T*, Yau KW. (2008) Quantal noise from human red cone pigment. Nature Neuroscience. 11(5):565-71 (* equal contributions)

 

9.   Xue T, Siu CW, Lieu DK, Lau CP, Tse HF, Li RA. (2007) Mechanistic role of I(f) revealed by induction of ventricular automaticity by somatic gene transfer of gating-engineered pacemaker (HCN) channels. Circulation. 115(14):1839-1850.

 

10. El-Kholy W, MacDonald PE, Fox JM, Bhattacharjee A, Xue T, Gao X, Zhang Y, Stieber J, Li RA, Tsushima RG, Wheeler MB. (2007) Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells. Mol Endocrinol. 21(3):753-764.

 

11. Tse HF, Xue T, Lau CP, Siu CW, Wang K, Zhang QY, Tomaselli GF, Akar FG, Li RA (2006). A bio-artificial sinus node constructed via in vivo gene transfer of an engineered pacemaker (HCN) channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model. Circulation 114: 1000-1011. Issue highlights, GROUND-BREAKING STUDY OF 2007 AHA.

 

12. Ardehali H, Xue T, Dong P, Machamer C (2005). Targeting of the mitochondrial membrane proteins to the cell surface for functional studies. Biochem Bioph Res Comm. 338(2):1143-51.

 

13. Abraham MR, Henrikson CA, Tung L, Chang MG, Aon M, Xue T, Li RA, O'Rourke B, Marban E (2005). Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ Res. 97:159-67.

 

14. Moore JC, van Laake LW, Braam SR, Xue T, Tsang SY, Ward D, Passier R, Tertoolen LL, Li RA, Mummery CL (2005). Human embryonic stem cells: Genetic manipulation on the way to cardiac cell therapies. Reprod Toxicol. 20:377-91.

 

15. Azene EM, Xue T, Marban E, Tomaselli GF, Li RA (2005). Non-equilibrium behavior of HCN channels: Insights into the role of HCN channels in native and engineered pacemakers. Cardiovasc Res. 67:263-73.

 

16. Wang G*, Xue T*, Tsang SY, Wong J, Cheng L, Zhang J, Li GR, Lau CP, Li RA, Tse HF (2005). Electrophysiological properties of pluripotent human and mouse embryonic stem cells. Stem Cells. 23(10):1526-34. (* equal contributions)

 

17. Xue T*, Cho H*, Akar F*, Tsang SY, Jones S, Marbán E, Tomaselli GF, Li RA (2005). Functional Integration of Electrically Active Cardiac Derivatives from Genetically Engineered Human Embryonic Stem Cells with Quiescent Recipient Ventricular Cardiomyocytes. Insights into the Development of Cell-Based Pacemakers. Circulation. 111:11-20. issue highlights, (Best Paper Award, Circulation. 2005) (* equal contribution)

 

18. Xue T, Sato K, Kodama K, Ennis I, French RJ, Li RA (2003). Novel interactions identified between μ-conotoxin and the Na+ channel Domain I P-loop: Implications for toxin-pore binding geometry. Biophys. J. 85(4):2299-310.

 

19. Azene EM*, Xue T*, Li RA (2003). Molecular basis of the effects of potassium on heterologously-expressed pacemaker (HCN) channels. J. Physiol. (London) 547(2):349-356. (* equal contributions )

 

20. Henrikson CA, Xue T, Dong P, Sang D, Marbán E, Li RA (2003). Identification of a surface charged residue in the S3-S4 linker of pacemaker (HCN) channel that influences activation gating. J. Biol. Chem. 278(16):13647-54.

 

21. Li RA, Ennis I, Xue T, Nguyen HM, Tomaselli GF, Goldin AL, Marbán E (2003). Molecular basis of isoform-specific μ-conotoxin block of cardiac, skeletal muscle and brain Na channels. J. Biol. Chem. 278(10):8717-24.

 

22. Xue T, Li RA (2002). An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification.   J. Biol. Chem. 277(48):46233-42.

 

23. Xue T, Marbán E, Li RA (2002). Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: Insights into structure-function relationships and multimerization. Circ. Res. 90:1267-1273.

 

24. Li RA, Sato K, Kodama K, Kohno T, Xue T, Tomaselli GF, Marban E. (2002). Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore. FEBS Lett. 511(1-3):159-164.

 

Submitted and In-Preparation:

 

25. Fu YB*, Xue T*, Kefalov V*, Wang ZY, Shulga-Morskoy SV, Lem J, Yau KW. (2014). G???subunits are required for the proper termination of rod photoresponse. In Preparation. (* equal contributions)

 

 

受邀讲座:

Groundbreaking Studies in the Practice of Cardiovascular Medicine”

American Heart Association, Chicago                               11/2006

“Beginning of Vision: From Single Cell Physiology to Regenerative Medicine”

Hong Kong University, Hong Kong                                         06/2008

Melanopsin Signaling in Mammalian Iris and Retina”

Virginia Commonwealth University, Richmond, VA                     10/2011

Melanopsin Signaling in Mammalian Eye”

RIKEN, Center for Development Biology, Kobe, Japan               11/2011

Melanopsin Signaling in the Eye”

University of Texas Southwestern Medical Center                         01/2012

Northwestern University                                           01/2012

SUNY Upstate Medical University                                         02/2012

University of California, San Francisco                           02/2012

Yale University                                                   03/2012

University of Massachusetts                                       08/2013

The 10th Biennial Conference of the Chinese Neuroscience Society (Invited talk)   09/2013

 

专利  (pending):

1.   "Modulation of Bio-electrical Rhythms Via a Novel Engineering Approach" WO2006/017566

2.   "Customizing Stem Cell-derived Cardiomyocytes for Transplantation"     WO2006/017567

3.   "A Novel Genetic Approach to inhibit or Eliminate the Tumorgenicity of Human Embryonic Stem Cells and/or their Derivatives After Transplantation"       WO2006/091852

 

Social activity:

2013-present       中国细胞生物学学会,青年委员会委员。

2014-present       中国睡眠研究会睡眠生物节律专业委员会,常务委员