赵允教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 527

 

赵允博士

 

联系方式

中国科学院上海生命科学研究院生物化学与细胞生物学研究所

上海市岳阳路320

生化细胞新大楼501房间

邮编:200031

电话: (021)54921618

Email: yunzhao@sibcb.ac.cn

 

学习工作背景:

200810至今:   中科院上海生物化学与细胞生物学研究所,研究员,博士生导师

20043—200810月:  美国德州大学西南医学中心,发育生物学系,博士后

20019—20042月:   美国哈佛大学医学院 Berman Gund 实验室,博士后

19968—20017月:

19928—19967月:   北京大学生命科学学院,分子细胞生物学专业,博士

北京市科委营养源研究所,助理工程师

19889—19927月:   山东大学微生物系,微生物学专业,学士

 

所获奖励:

2014 明治生命科学奖

2009:   入选上海市“浦江人才”

2008:   入选“中科院百人计划”

2006:   American Heart Association Postdoctoral Fellowship

2006:   中国教育部“科技进步”一等奖

2003:   中国教育部“全国优秀博士论文”一等奖

2003:   北京大学“优秀博士学位论文”一等奖

2001:   北京大学优秀毕业生

2001:   中国教育部“科技进步奖”一等奖

 

协会成员:

美国遗传学会会员

中国细胞生物学会会员

中国遗传学会会员

中国生化学会会员

《中国细胞生物学杂志》编委会成员

Acta Biochimica et Biophysica Sinica 编委

研究领域:

多年从事细胞生物学及发育生物学的研究,特别是集中在与形态发生素相关的信号转导途径(例如HedgehogWntHippo等信号途径)的研究。并利用模式生物针对发育过程中组织、器官大小的形成机制以及肿瘤的发生、发展与疾病发生机制进行了深入的研究。在相关领域先后在Nature, Nature GeneticsGene & DevelopmentDevelopmental Cell, Journal of Cell BiologyHuman Molecular GeneticsProceeding of National Academy of Sciences, Journal of Biological Chemistry, Cellular and Molecular Life Science以及FEBS Letters等杂志发表多篇论文。

 

发表文章:

 

1.    Feifei Mao, Xiaofeng Yang, Lin Fu, Xiangdong Lv, Zhao Zhang, Wenqing Wu, Siqi Yang, Zhaocai Zhou, Lei Zhang and Yun Zhao#. The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway. Journal of Biological Chemistry. 2014, 289(32):22333-22341. (#Corresponding author)

2.    Chuanchuan Li, Miao Feng, Zhubing Shi, Qian Hao, Xiaomin Song, Wenjia Wang, Yun Zhao, Shi Jiao and Zhaocai Zhou. Structural and biochemical insights into the activation mechanisms of germinal center kinase OSR1. Journal of Biological Chemistry. 2014, 2014, 289(52):35969-35978.

3.    Shi Jiao, Huizhen Wang, Zhubing Shi, Aimei Dong, Wenjing Zhang, Xiaomin Song, Feng He, Yicui Wang, Zhenzhen Zhang, Wenjia Wang, Xin Wang, Tong Guo, Peixue Li, Yun Zhao, Hongbin, Ji, Lei Zhang and Zhaocai Zhou. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell. 2014, 25(2):166-180.

4.    Lianxin Hu, Hongling Huang, Jinhui Li, Meng-xin Yin, Yi Lu, Wenqing Wu, Rong Zeng, Jin Jiang, Yun Zhao and Lei Zhang. Drosophila casein kinase 2 (CK2) promotes warts protein to suppress yorkie protein activity for growth control. Journal of Biological Chemistry. 2014, 289(48):33598-33607.

5.    Cuicui Chen, Zhubing Shi, Wenqing Zhang, Min Chen, Feng He, Zhenzhen Zhang, Yicui Wang, Miao Feng, Wenjia Wang, Yun Zhao, Jerry H. Brown, Shi Jiao and Zhaocai Zhou. Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex. Journal of Biological Chemistry. 2014, 289(14):9651-9561

6.    Hongling Huang, Jinhui Li, Lianxin Hu, Ling Ge, Hongbin Ji, Yun Zhao# and Lei Zhang#. Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling. Developmental Biology. 2014, 385(2):211-219. (#Corresponding author)

7.    Zuoyun Wang, Yihua Sun, Bin Gao, Yi Lu, Rong Fang, Yijun Gao, Tian Xiao, Xin-yuan Liu, William Pao, Yun Zhao#, Haiquan Chen# and Hongbin Ji#. Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome. Cancer Letters. 2014, 342(1):36-42. (#Corresponding author)

8.    Zhao Zhang, Jing Feng, Chenyu Pan, Xiangdong Lv, Wenqing Wu, Zhaocai Zhou, Feng Liu, Lei Zhang#, and Yun Zhao#. Atrophin/Rpd3 complex represses Hedgehog signaling by acting as a co-repressor of CiR. Journal of Cell Biology. 2013, 203(4):575-583. (#Corresponding author)

9.    Zhao Zhang, Xiangdong Lv, Wen Chi Yin, Xiaoyun Zhang, Jing Feng, Wenqing Wu, Chi-chung Hui, Lei Zhang#, and Yun Zhao#. Ter94 ATPase Complex Targets K11-linked Ubiquitinated Ci to Proteasomes for Partial Degradation. Developmental Cell. 2013, 25(6):636-644. (#Corresponding author)

10.  Shoujun Huang, Zhao Zhang, Chunxia Zhang, Xiangdong Lv, Xiudeng Zheng, Zhenping Chen, Liwei Sun, Hailong Wang, Yuanxiang Zhu, Jing Zhang, Shuyan Yang, Yi Lu, Qinmiao Sun, Yi Tao, Feng Liu, Yun Zhao#, and Dahua Chen#. Activation of Smurf E3 ligase promoted by Smoothened regulates Hedgehog signaling through targeting Patched turnover. PLoS Biology. 2013, 11(11):e1001721. (#Corresponding author)

11.  Yan Zhang, Lin Fu, Xiaolong Qi, Zhenyi Zhang, Yuanxin Xia, Jianhang Jia, Jin Jiang, Yun Zhao#, and Geng Wu#. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nature Communications. 2013, 4:2608 (#Corresponding author)

12.  Yunyun Jin, Jinjin Xu, Meng-Xin Yin, Yi Lu, Lianxin Hu, Peixue Li, Peng Zhang, Zengqiang Yuan, Margaret S Ho, Hongbin Ji, Yun Zhao#, and Lei Zhang#. Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling. eLIFE. 2013, 2:e00999. (#Corresponding author)

13.  Xiaofeng Yang, Feifei Mao, Xiangdong Lv, Zhao Zhang, Lin Fu, Yi Lu, Wenqing Wu, Zhaocai Zhou, Lei Zhang#, and Yun Zhao#. Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. Journal of Cell Science. 2013, 126(18):4230-4238. (#Corresponding author)

14.  Tong Guo, Yi Lu, Peixue Li, Mengxin Yin, Dekang Lv, Wenjing Zhang, Huizhen Wang, Zhaocai Zhou, Hongbin Ji, Yun Zhao#, and Lei Zhang#. A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity. Cell Research. 2013, 23(10):1201-1214. (#Corresponding author)

15.  Hong-Ling Huang, Shimin Wang, Meng-Xin Yin, Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, Hongbin Ji, Jin Jiang, Yun Zhao#, Xin-Yuan Liu#, Lei Zhang#. Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association. PLoS Biology. 2013, 11(8):e1001620. (#Corresponding author)

16.  Zhao Zhang#, Chenyu Pan, and Yun Zhao#. Hedgehog in the Drosophila testis niche: what does it do there? Protein and Cell. 2013, 4(9):650-655. (invited review) (#Corresponding author)

17.  Xiangdong Lv, Lin Fu, and Yun Zhao#. aPKC ι/λ: a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC. Acta Biochimica et Biophysica Sinica. 2013, 45(7):610-611. (invited review) (#Corresponding author)

18.  Min Luo, Te Ling, Wenbing Xie, He Sun, Yonggang Zhou, Qiaoyun Zhu, Meili Shen, Le Zong, Guoliang Lyu, Yun Zhao, Tao Ye, Jun Gu, Wei Tao, Zhigang Lu, and Ingrid Grummt. NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells. Stem Cells. 2013, 31(7):1278-1286. 

19.  Dawei Shi, Xiangdong Lv, Zhao Zhang, Xiaofeng Yang, Zhaocai Zhou, Lei Zhang#, and Yun Zhao#. Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts Is Essential for High Hedgehog Activity Transduction. Journal of Biological Chemistry. 2013, 288:12605-12614. (#Corresponding author)

20.  Zhao Zhang, Xiangdong Lv, Jin Jiang, Lei Zhang#, and Yun Zhao#. Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis. Cell Research. 2013, 23:573-576. (#Corresponding author)

21.  Zhubing Shi, Shi Jiao, Zhen Zhang, Miao Ma, Zhao Zhang, Cuicui Chen, Ke Wang, Huizhen Wang, Wenjia Wang, Lei Zhang, Yun Zhao#, and Zhaocai Zhou#. Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism. Structure. 2013, 21:449–461. (#Corresponding author) 

22.  Meng Zhang, Liang Dong, Zhubing Shi, Shi Jiao, Zhen Zhang, Wenqing Zhang, Guogang Liu, Cuicui Chen, Miao Feng, Qian Hao, Wenjia Wang, Mengxin Yin, Yun Zhao, Lei Zhang, and Zhaocai Zhou. Structural Mechanism of CCM3 Heterodimerization with GCKIII Kinases. Structure. 2013, 21:680-688.

23.  Wenjia Wang, Zhubing Shi, Shi Jiao, Cuicui Chen, Huizhen Wang, Guoguang Liu, Qiang Wang, Yun Zhao, Mark I Greene, Zhaocai Zhou. Structural insights into SUN-KASH complexes across the nuclear envelope. Cell Research. 2012, 22:1440-1452.

24.  Shuo Shi, Yue-Zhen Deng, Jiang-Sha Zhao, Xiao-Dan Ji, Jun Shi, Yu-Xiong Feng, Guo Li, Jing-Jing Li, Di Zhu, H. Phillip Koeffler, Yun Zhao, Dong Xie. RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. Journal of Biological Chemistry. 2012, 287(11):7845-7858.

25.  Yunyun Jin, Liang Dong, Yi Lu, Wenqing Wu, Qian Hao, Zhaocai Zhou, Jin Jiang, Yun Zhao#, and Lei Zhang#. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. Journal of Biological Chemistry. 2012, 287:5784-5796. (#Corresponding author)

26.  Yanyan Zhang, Feifei Mao, Yi Lu, Wenqing Wu, Lei Zhang#, and Yun Zhao#. Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. Cell Research. 2011, 21:1436-1451. (#Corresponding author) 

27.  Yongbin Chen, Shuang Li, Chao Tong, Yun Zhao, Bing Wang, Yajuan Liu, Jianhang Jia, Jin Jiang. G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes and Development. 2010, 24(18):2054-2067.

28.  Jun Yang, Xiaoqing Liu, Yun Zhao, Michael Adamian, Basil Pawlyk, Xun Sun, D. Randy McMillan, M. Charles Liberman, Tiansen Li. Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss. PLoS Genetics. 2010, 6(5):e1000955.

29.  Joel M. Hyman, Ari J. Firestone, Vivi M. Heine, Yun Zhao, Cory A. Ocasio, Kyuho Han, Mark Sun, Paul G. Rack, Surajit Sinha, Jason J. Wu, David E. Solow-Cordero, Jin Jiang, David H. Rowitch, James K. Chen. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proceedings of the National Academy of Sciences USA. 2009, 106(33):14132-14137.

30.  Hongbo Yang, Jing Xiang, Nengdong Wang, Yun Zhao, Joel Hyman, Jin Jiang, James K. Chen, Zhen Yang and Shuo Lin. Converse conformational control of smoothened activity by structurally related small molecules. Journal of Biological Chemistry. 2009, 284(31):20876-20884.

31.  Yun Zhao, Chao Tong and Jin Jiang. Transducing the Hedgehog signal across the plasma membrane. Fly. 2007, 1(6):333-336. (invited review)

32.  Yun Zhao, Chao Tong and Jin Jiang. Hedgehog regulates Smoothened activity by inducing a conformational switch. Nature. 2007, 450:252-258. (Research Article)

33.  Jun Yang, Basil Pawlyk, Xiaohong Wen, Michael Adamian, Maria Soloviev, Norman Michaud, Yun Zhao, Michael A. Sandberg, Clint L. Makino, Tiansen Li. Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals. Human Molecular Genetics. 2007, 16(9):1017-1029.

34.  Xiaoqing Liu, Yun Zhao, Basil Pawlyk, Margot Damaser and Tiansen Li. Failure of Elastic Fiber Homeostasis Leads to Pelvic Floor Disorders. American Journal of Pathology. 2006, 168(2):519-528.

35.  Wensheng Zhang*, Yun Zhao*, Chao Tong, Gelin Wang, Bing Wang, Jianhang Jia, and Jin Jiang. Hedgehog-regulated Costal2/kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Developmental Cell. 2005, 8(2):267-278. (*equal contribution).

36.  Xiaoqing Liu, Yun Zhao, Jiangang Gao, Basil Pawlyk, Barry Starcher, Jeffrey A Spencer, Hiromi Yanagisawa, Jian Zuo and Tiansen Li. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nature Genetics. 2004, 36(2):178-182.

37.  Yun Zhao, Dong-Hyun Hong, Basil Pawlyk, Guohua Yue, Michael Adamian, Marcin Grynberg, Adam Godzik, and Tiansen Li. The retinitis pigmentosa GTPase Regulator (RPGR)-interacting protein: Subserving RPGR function and participating in disk morphogenesis. Proceedings of the National Academy of Sciences USA. 2003, 100(7):3965-3970.

38.  Yun Zhao, Zhigang Lu, Min Wu, Qingqing Han, Wei Tao, and Zhonghe Zhai. Effect of phosphocreatine on apoptosis induced in Xenopus cell-free system. Journal of Biological Chemistry. 2001, 276:34573-34578.

39.  Yun Zhao, Min Wu, Yan Shen, and Zhonghe Zhai. Analysis of nuclear apoptotic process in a cell-free system. Cellular and Molecular Life Science. 2001, 58:298-306.

40.  Yun Zhao, Yan Shen, Min Wu, and Zhonghe Zhai. The change of Nuclear Matrix Lamina in apoptosis of nucleus. J Chinese Electronic Microscope. 2001, 20(2):87-92.

41.  Min Wu, Yun Zhao, and Zhonghe Zhai. The ultrastructural observation of apoptotic mouse liver cell nuclei. Journal of Chinese Electronic Microscope. 2001, 20(1):21-26.

42.  Yun Zhao, Xiaoling Liu, Min Wu, Wei Tao, and Zhonghe Zhai. In vitro nuclear reconstitution could be induced in a plant cell-free system. FEBS Letters. 2000, 480:208-212.

43.  Zhengfan Jiang, Yun Zhao, Xia Hong, and Zhonghe Zhai. Nuclear apoptosis induced by isolated mitochondria. Cell Research. 2000, 10:221-232.

44.  Yun Zhao, Zhengfan Jiang, Yingli Sun, and Zhonghe Zhai. Apoptosis of mouse liver nuclei induced in the cytosol of carrot cells. FEBS Letters. 1999, 448:197-200.

45.  Yun Zhao, Yingli Sun, Zhengfan Jiang, and Zhonghe Zhai. Apoptosis of carrot nuclei in in vitro system induced by cytochrome c. Chinese Scince Bulletin. 1999, 44:1497-1501.

46.  Yingli Sun, Yun Zhao, Xia Hong, and Zhonghe Zhai. Cytochrome c release and caspase activation during menadione-induced apoptosis in plants. FEBS Letters. 1999, 462:317-321.

47.  Yingli Sun, Yun Zhao, Chunxiang Liu, and Zhonghe Zhai. Cytochrome c Can Induce Programmed Cell Death in Plant Cells, Acta Botanica Sinica. 1999, 41:379-383.

48.  Yingli Sun, Yun Zhao, Jian Wang, and Zhonghe Zhai. Distribution of NuMA-like Proteins and Its Changes During Cell-cycle in Plant cells. Acta Botanica Sinica. 1999, 41:235-240.

49.  Danying Chen, Yun Zhao, Dazhong Zhao, and Zhonghe Zhai. Study of intermediate filaments in Adiantum philippense and comparative analysis of karetin-like proteins in some plant species. Acta Botanica Sinica. 1998, 40:790-795.