张 雷教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 518

 

张雷博士

中科院上海生化细胞所研究员、博士生导师

出生年月:1972.05

办公地点:徐汇区岳阳路320号新大楼507,上海,200031

电话:021-54921336

Emailrayzhang@sibcb.ac.cn

 

教育背景:

1991.9-1995.7    吉林大学分子生物学系本科(生物化学)

1995.9-1998.7    吉林大学酶工程国家重点实验室硕士(生物化学)

1998.9-2001.7    中科院遗传与发育研究所博士(发育生物学)

 

工作经历:

2001.12-2008.12   美国西南医学中心,博士后,助理讲师

2009.01-  至今上海生化细胞所研究员

 

学术奖项与活动:

 

2009年入选中科院“百人计划”, 2014年“百人计划”终期评估获得优秀;2009年获上海市“浦江人才计划”资助。《中国细胞生物学学报》、《遗传》、《ABBS》编委,eLife, Cell Res 等杂志应邀审稿人。中国果蝇大会组委会成员;2015年第三届亚太果蝇大会(3APDRCsession chair

研究方向:

 

发育过程的组织分化与生长调控

 

主持的课题

1)  中国科学院创新交叉团队: Hippo信号研究交叉团队, 2014.09-2017.09,负责人

2)  国家自然科学基金面上项目,Hippo 信号转导途径中CK2Yki/YAP的稳定性和活性调控机制,2012.01-2015.12,负责人

3)  国家自然科学基金面上项目,筛选和鉴定Hippo信号转导途径中抑制Hippo蛋白激酶活性的新成员,2014.01-2017.12,负责人

4)  中国科学院战略性先导专项,谱系转化及细胞命运改变的疾病模型建立及机理研究,2011.01-2015.12,负责人。

5)  科技部蛋白质重大科学研究计划,上皮组织的形成、更新及其调节机理,2012.01-2016.08,学术骨干

6)  科技部蛋白质重大科学研究计划,细胞生长调控的重要蛋白质群的功能与作用机制,2010.01-2014.08,学术骨干。

7)  国家自然科学基金面上项目,Hippo 信号转导途径中Hippo 蛋白激酶的活性调节机制研究,2010.01-2012.12,负责人

8)  中国科学院“百人计划”引进国外杰出人才项目,发育与信号转导调控,  2010.01-2014.12,负责人

9)  上海市“浦江人才计划”团队,细胞编程及重编程后胚胎发育中HhHippo 信号通路的研究, 2009.07-2011.07 负责人

 

专利申请

 

VGLL4基因治疗肿瘤的用途及其相关药物专利申请号:201310493193.4

 

发表论文(# corresponding author):

 

1.    Ye Zhu, Dong Li, Yadong Wang, Chunli Pei, Song Liu, Lei Zhang, Zengqiang Yuan, Peng Zhang  Brahma regulates the Hippo pathway activity through forming complex with Yk–Sd and regulating the transcription of Crumbs. Cellular Signalling 2014 (In Press)

 

2.    Mengxin Yin and Lei Zhang#  Hippo signaling in epithelial stem cells. Acta Biochimica et Biophysica Sinica 2015, 47:39-45 (invited review) (# corresponding author)

Guest editor: ABBS special issue on Hippo signaling.

 

3.    Lianxin Hu, Hongling Huang, Jinhui Li, Meng-Xin Yin, Yi Lu, Wenqing Wu, Rong Zeng, Jin Jiang, Yun Zhao and Lei Zhang# Drosophila CK2 promotes Wts to suppress Yki activity for growth control. The Journal of Biological Chemistry 2014, 289:33598-33607 # corresponding author)

 

4.    Hongling Huang, Jinhui Li, Lianxin Hu, Ling Ge, Hongbin Ji, Yun Zhao#, Lei Zhang#  Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo. Developmental Biology 2014, 385:211-219 # corresponding author)

 

5.    Shi Jiao, Huizhen Wang, Zhubing Shi, Aimei Dong, Wenjing Zhang, Xiaomin Song, Feng He, Yicui Wang, Zhenzhen Zhang, Wenjia Wang, Xin Wang, Tong Guo, Peixue Li, Yun Zhao, Hongbin Ji#, Lei Zhang#, Zhaocai Zhou#. A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer Cell 2014, 25: 166-180 # corresponding author)

 

6.    Wenjing Zhang, Yijun Gao, Peixue Li, Zhubing Shi, Tong Guo, Fei Li, XiangKun Han, Yan Feng, Chao Zheng, Zuoyun Wang, Fuming Li, Haiquan Chen, Zhaocai Zhou#, Lei Zhang# and Hongbin Ji#  VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEADs transcriptional complex. Cell Research  2014, 24: 331-343# corresponding author)

 

7.    Yijun Gao, Wenjing Zhang, Xiangkun Han, Fuming Li, Xujun Wang, Rui Wang, Zhaoyuan Fang, Xinyuan Tong, Shun Yao, Fei Li, Yan Feng, Yihua Sun, Yingyong Hou, Zhongzhou Yang, Kunliang Guan, Haiquan Chen, Lei Zhang# & Hongbin Ji#  YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression. Nat Communications 2014, 5:4629 # corresponding author)

 

8.    Xiangkun Han, Fuming Li, Zhaoyuan Fang, Yijun Gao, Fei Li, Rong Fang, Shun Yao, Yihua Sun, Li Li, Wenjing Zhang, Huimin Ma, Qian Xiao, Gaoxiang Ge, Jing Fang, Hongda Wang, Lei Zhang, Kwok-kin Wong, Haiquan Chen, Yingyong Hou, Hongbin Ji. Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma. Nat Communications 2014, 5:3261

 

9.    Feifei Mao, Xiaofeng Yang, Lin Fu, Xiangdong Lv, Zhao Zhang, Wenqing Wu, Siqi Yang, Zhaocai Zhou, Lei Zhang, Yun Zhao  Kto-Skd complex can regulate ptc expression by interacting with Ci in Hedgehog signaling pathway. The Journal of Biological Chemistry 2014 289 (32): 22333-41

 

 

10.  Yunyun Jin, Jinjin Xu, Meng-Xin Yin, Yi Lu, Lianxin Hu, Peixue Li, Peng Zhang, Zengqiang Yuan, Margaret S. Ho, Hongbin Ji, Yun Zhao#, Lei Zhang#  Brahma is essential for Drosophila Intestinal Stem Cell proliferation and regulated by Hippo signaling. eLife 2013 2: e00999  # corresponding author

 

 

11.  Hongling Huang, Shimin Wang, Mengxin Yin,Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, Hongbin Ji, Jin Jiang, Yun Zhao#, Xin-Yuan Liu# and Lei Zhang#  Par-1 regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association. PLoS Biology 2013,11(4) e1001620 (Press released by PLoS Biology)# corresponding author

 

12.  Tong Guo, Yi Lu, Peixue Li, Meng-Xin Yin, Dekang Lv, Wenjing Zhang, Huizhen Wang, Zhaocai Zhou, Hongbin Ji, Yun Zhao#, Lei Zhang#  A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity. Cell Research 201323:1201-1214# corresponding author)

 

13.  Zhao Zhang, Jing Feng, Chenyu Pan, Xiangdong Lv, Wenqing Wu, Zhaocai Zhou,Feng Liu, Lei Zhang# and Yun Zhao#   Atrophin/Rpd3 complex represses Hedgehog signaling by interacting with Ci. The Journal of Cell Biology 2013, 203:575-583 # corresponding author)

 

14.  Zhao Zhang,  Xiangdong Lv,  Wen-chi Yin,  Xiaoyun Zhang, Jing Feng, Wenqing Wu, Chi-chung Hui, Lei Zhang# and Yun Zhao#  Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation. Developmental Cell 2013, 25: 636-644 (# corresponding author)

 

15.  Xiaofeng Yang, Feifei Mao, Xiangdong Lv, Zhao Zhang, Lin Fu, Yi Lu, Wenqing Wu, Zhaocai Zhou, Lei Zhang#, and Yun Zhao#. Drosophila Vps36 is involved in Hh signaling by regulating Smo trafficking. Journal of Cell Science. 2013126:4230-4238 (#Corresponding author)

 

16.  Hongling Huang, Wenqing Wu, Lei Zhang# and Xin-Yuan Liu# Drosophila Ste-20 family protein kinase, Hippo, modulates Fat cell proliferation.  PLoS One  2013, 8: e61740   (# corresponding author)

 

17.  Dawei Shi, Xiangdong Lv, Zhao Zhang, Xiaofeng Yang, Zhaocai Zhou, Lei Zhang#, and Yun Zhao# Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts is Essential for High Hh Activity Transduction    The Journal of Biological Chemistry  2013,  288(18): 12605-12614 (# corresponding author)

 

18.  Meng Zhang, Liang Dong, Zhubing Shi, Shi Jiao, Zhen Zhang, Wenqing Zhang, Guoguang Liu, Cuicui Chen, Miao Feng, Qian Hao, Wenjia Wang, Mengxin Yin, Yun Zhao, Lei Zhang#and Zhaocai Zhou#. Structural Mechanism of CCM3 Heterodimerization with GCKIII Kinases. Structure 2013, 21:680-688 (# corresponding author)

 

19.  Zhao Zhang, Xiangdong Lv, Jin Jiang, Lei Zhang#, Yun Zhao#. Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis. Cell Research 2013 23(4): 573-576 ( # corresponding author)

 

20.  Zhubing Shi, Shi Jiao, Zhen Zhang, Miao Ma, Zhao Zhang, Cuicui Chen, Ke Wang, Huizhen Wang, Wenjia Wang, Lei Zhang, Yun Zhao, and Zhaocai Zhou. Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism. Structure 2013, 21: 449-461

 

21.  Yunyun Jin, Liang Dong, Yi Lu, Wenqing Wu, Qian Hao, Zhaocai zhou, Jin Jiang, Yun Zhao#  and Lei Zhang#. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. The Journal of Biological Chemistry 2012, 287: 5784-5796 (# corresponding author)

 

22.  Mengxin Yin and Lei Zhang#. Hippo signaling, a hub of growth control, tumor suppression and pluripotency maintenance. Journal of Genetics and Genomics 2011, 38: 471-481 (invited review) (# corresponding author) 

 

23.  Yanyan Zhang, Feifei Mao, Yi Lu, Wenqing Wu, Lei Zhang# and Yun Zhao#. Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. Cell Research 2011, 21: 1436-1451 (# corresponding author)

 

24.  Fangfang Ren, Lei Zhang, Jin Jiang. Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms. Developmental Biology  2010, 337, 303-312

 

25.  Lei Zhang, Tao Yue and Jin Jiang. Hippo signaling pathway and organ size control. 2009, Fly 3(1), 1-6 (invited review).

 

26.  Lei Zhang, Fangfang Ren, Qing Zhang, Yongbin Chen, Bing Wang, and Jin Jiang. The TEAD/TEF family of transcription factor Scalloped mediates nuclear responses to the Hippo pathway in organ size control.  Developmental Cell  200814377-387

 

27.  Lei Zhang, Jianhang Jia, Bing Wang, Kazuhito Amanai, Keith A. Wharton Jr, Jin Jiang. Regulation of wingless signaling by the CKI family in Drosophila limb development. Developmental Biology 2006, 299: 221-237

 

28.  Qing Zhang*, Lei Zhang*, Bing Wang, Chan-Yen Oh, Cheng-Ting Chien, ang Jin Jiang. A Hedgehog-Induced BTB Protein Modulates Hedgehog Signaling by Degrading Ci/Gli Transcription Factor. Developmental Cell 2006, 10719-729 (* Equally contributed to this work)

 

29.  Jianhang Jia*, Lei Zhang*, Qing Zhang* et al. Phosphorylation by Double-time/CKIε and CKIα targets Cubitus interruptus for Slimb/β-TRCP mediated proteolytic processing. Developmental cell  2005, 9: 819-830  (* Equally contributed to this work)

 

30.  Zhipan Yang, Lei Zhang, Fengqiu Diao, Meijuan Huang, Naihu Wu Sucrose regulates elongation of Carrot somatic embryo radicles as a signal molecule.      Plant Molecular Biology 200454441-459

 

31.  HuiXin.Lin, Lei Zhang, Zhipan Yang etal. Molecular Characterization of Poly(A)-binding Protein from Daucus carota.    DNA sequencing 2004, 14(2): 147-153

 

32.  Yiming Liu, Fengqiu Diao, Lei Zhang, Meijuan Huang, Naihu Wu  Cloning and function analysis of DcLEA1 , a new number of LEA gene family Progress in Natural Science,14(5) 20-26 (2004)

 

33.  Huixin Lin, Lei Zhang, Zhipan Yang, et al  Isolation and Functional Identification of DcPAB from Daucus carota  Chinese Journal of Biochemistry and Molecular biology 2004, 20 (3)319-324 (in Chinese, English abstract)

 

34.  Zhipan Yang, Lei Zhang, Fengqiu Diao et al.  Cloning and expression of DnaJ homolog in Carrot somatic embryo. Progress in Natural Science 2003,13(5) 350-356

 

35.  Lei Zhang, Zhipan Yang, Yiming Liu et al.  Analysis of gene expression in carrot somatic embryonic development by differential screening of a cDNA library.  Progress in Natural Science 2002,12(3) 261-265  (in Chinese)

 

36.  Lei Zhang, Fengqiu Diao, Zhipan Yang et al. Isolation and characterization of a new member of sucrose carrier cDNA from carrot by functional expression in yeast. Chinese Science Bulletin 2001,46(14) 1190-1195  (in Chinese)

 

37.  Fengqiu Diao, Lei Zhang, Meijuan Huang et al.  Isolation of development-related genes in somatic embryo radicle of carrot (Daucus carota L.) using modified cDNA RDA.     Science in China. 2000, 43(1) 47-56

 

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