王红艳教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 878

 

王红艳/ Dr. Hongyan Wang

电话:+86 (0) 21-54921086

Email: hongyanwang@sibcb.ac.cn

网页:http://www.sibcb.ac.cn/PI.asp?id=132

地址:中科院上海生科院生化与细胞所,

上海岳阳路320号,邮编200031

 

 

王红艳,女, 197511月出生。2010年回国,担任中科院上海生科院生化与细胞所研究员,博士生导师,细胞生物学国家重点实验室研究组组长。

申请者的研究方向:T 淋巴细胞和巨噬细胞作为最重要的免疫细胞类型,通过严格精密的整合素活化的信号转导网络,达到特异性迁移到病理或受损的靶组织,调控炎症反应,广泛参与抗感染、自身免疫性疾病、组织损伤修复等功能。申请者的科研工作集中探讨:免疫细胞调控炎症及炎症相关疾病的新机制。至今共发表SCI论文21 篇,包括以责任作者或共同责任作者、第一作者或共同第一作者的身份在Immunity Nat ImmunolJ Exp MedPNASMCBRetrovirologyJ Neuroinflammation等期刊上发表11篇论文。

1. 受教育经历

2003/09-2006/07: 英国伦敦帝国理工学院,博士;导师:Christopher E. Rudd教授

1998/09-2001/07: 安徽医科大学免疫系和中国预防医学科学院病毒所基因工程国家重点实验室,硕士

1993/09-1998/07: 安徽医科大学,临床医学系,本科

2.研究工作经历

2010/03-至今: 中科院上海生科院生化与细胞所,研究员,博导,研究组长

2006/07-2010/03: 英国剑桥大学病理系,Research Fellow

2001/10-2006/07: 英国伦敦帝国理工学院免疫系,研究助理

3.奖励或荣誉

2014年国家优秀青年科学基金

2011年获中国科学院“百人计划”择优资助

2011年获上海浦江人才计划资助

2009年英国免疫学会旅行奖

2008年美国Keystone大会旅行奖

2007年英国剑桥大学CIMR年会墙报一等奖

2006年第13届全英华人生命科学大会墙报一等奖

4.期刊编委和审稿人

Cell Biochemistry and Function的编委

中国细胞生物学学报的编委

ImmunologyEMBO Reports审稿人

5.主持或参加科研项目及人才基金项目情况

1)  2014年获"优青"支持。

2)  科技部重大科学研究计划(973)课题,2011CB505005,动物流感病毒变异、跨种间传播及致病的分子机制研究,2011.01-2015.12,执行中,子课题组长。

3)  科技部重大科学研究计划(973)课题,2012CB910800,炎症诱导肿瘤的分子调控网络研究,2012.01-2016.12,执行中,学术骨干。

4)  上海市浦江人才科研开发(A类),11PJ1410700CD4+ T淋巴细胞调控HIV-1病毒转录的分子机制研究,2011.04-2013.03,已结题,主持。

5)  自然科学基金面上项目,31070778CD8+ T细胞的活化,分化,杀伤和迁移功能的分子机制,2011.01-2013.1240万元,已结题,主持。

6)  中科院“百人计划”,免疫系统的信号转导与功能,2011.01-2013.12,主持。

 

6.  已发表的SCI文章

1.    Li C, Li W, Xiao J, Jiao S, Sheng C, Rudd CE, Wei B, Wang H#. ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy. EMBO Mol Med (2015, Minor Revision)

2.    Zhang Y, Lu Y, Ma L, Jiao S, Chen J, Gao Y, Liu C, Duan Z, Li D, He Y, Wei B#, Wang H#  Activation of vascular endothelial growth factor receptor-3 in macrophages restrains TLR-NF-B signaling and protects from endotoxin shock  Immunity, 2014, 40: 501-514 ; (Cover Story)

3.    Huang Y, Jiao S, Tao X, Tang Q#, Jiao W, Xiao J, Xu X, Zhang Y, Liang G, Wang H # Met-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection. J Neuroinflammation 2014,11:146;

4.    Zhang M, Zhou H, Zheng C, Xiao J, Zuo E, Liu W, Xie D, Shi Y, Wu C, Wang H, Li D, Li J. The Roles of Testicular C-kit Positive Cells in De novo Morphogenesis of Testis. Sci Rep. 2014; 4: 5936; 1-11

5.    Yu T, Tao Y, Yang1 M, Chen P, Gao X, Zhang Y, Zhang T, Chen Z, Hou J, Zhang Y, Ruan K, Wang H, Hu R. Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis. Cell Res. 2014:1-17

6.    Wei B#, Han L#, Abbink T, Elisabetta G, Lim D, Thaker YR, Gao W, Zhai R, Wang J, Lever A, Jolly C, Wang H# and Rudd CE#. Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors. Retrovirology, 2013:10:101

7.    Zhang Y and Wang H#. Integrin signaling and function in immune cells. Immunology, 2012;4135:267-75

8.    Li C, Xu X, Wang H# and Wei B#. PD-1 and CTLA-4 mediated inhibitory signaling for T cell exhaustion during chronic viral infections. Journal of Clinical & Cellular Immunology, 2012, S7-10.

9.    Yao Y, Wang Y, Chen F, Huang Y, Zhu S, Leng Q, Wang H, Shi Y, Qian Y. NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens. Cell Res. 2012;22(5):836-47. 

10.  Wang H#, Lim D and Rudd CE. Integrin signaling and immunopathology Semin Immunopathol 2010;32(2):173-82 (#corresponding author)

11.  Raab M, Wang H, Lu Y, Smith X, Wu Z, Strebhardt K, Ladbury JE, Rudd CE. T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes  Immunity 2010;32(4):541-56.  

12.  Wang H, Lv Y and Rudd CE. SKAP1 is dispensable for chemokine induced T-cell migration Immunol Letters 2010:128(2):148-53.

13.  Wang H, Wei B, Bismuth G, Rudd CE. SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility. PNAS 2009; 106(30):12436-41.

14.  Wang H and Rudd CE. SKAP-55, SKAP-55Related and ADAP adaptors modulate integrin-mediated immune cell adhesion. Trends Cell Biol 2008; 18(10):486-93.  

15.  Schenider H*, Wang H* (*equally contributed), Raab M, Valk E, Smith X, Lovatt M, Wu, Z, Strebhardt K, Rudd CE. Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-Cells. PLoS ONE. 2008;5;3(3):e1718

16.  Wang H, Liu H, Lu Y, Lovatt M, Wei B, Rudd CE. Functional defects of SKAP-55 deficient T-cells identify a regulatory role for the adaptor in LFA-1 adhesion. Mol Cell Biol. 2007;27(19):6863-75 

17.  Wei B, da Rocha Dias S, Wang H, Rudd CE. CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase. J Immunol. 2007;179(1):400-8. 

18.  Jo E-K, Wang H, and Rudd CE. An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R. J. Exp. Med. 2005;201(11):1733-9. 

19.  Wang H, McCane F, Gordan J, Wu X, Raab M, Malik T, Davis D, Rudd CE. ADAP-SLP-76 binding differently regulates the supramolecular activation complex (SMAC) formation vs. conjugate formation. J. Exp. Med. 2004;200:1063-1074

20.  Wang H*,  Moon EY*, Azouz A, Wu X, Smith A, Schneider H, Hogg N, Rudd CE. SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. Nat Immunol. 2003;4(4):366-74.

21.  Rudd CE, Wang H. Hematopoietic adaptors in T-cell signaling: potential applications to transplantation. Am J Transplant. 2003;3(10):1204-10. 

22.  Wilkinson B, Wang H, Rudd CE. Positive and negative adaptors in T cell signaling. Immunology 2004;111(4): 368-374.

 

国内被CSCD收录学术期刊:

1.  题名:TCR介导“inside-out”信号通路调控整合素的活化

作者:肖俊,韩磊,李春阳,徐晓燕,盛春,王红艳

单位:上海师范大学生命与环境科学学院

来源:中国细胞生物学学报, 2012, 34(8), 749-758

 

2.  题名:定向进化人α型干扰素基因家庭的研究

作者:段招军,王红艳,李武平,吕宏亮,赵军,魏开坤,马学军,侯云德

单位:中国疾病预防控制中心病毒病预防控制所

来源:病毒学报, 2003, 19(4), 301-305

 

3.  题名:人α型干扰素家族定向进化文库的构建及细胞筛选

作者:段招军,赵军,王红艳,魏开坤,吕宏亮,李武平,李玉英,侯云德

单位:中国预防医学科学院病毒学所

来源:病毒学报, 2001, 17(2), 172

 

专利申请:

VEGF-C在制备诊断败血症及重症细菌感染诊断试剂中的用途

申请号:201310548097.5    受理日期:2013.11.08

 

国际学术大会报告:

1.    Cold Spring Harbor meeting, USA (April 2014)

Oral presentation: Activation of VEGFR-3 in macrophages restrains TLR-NF-B signaling and protects from endotoxin shock

2.    2014 Beijing-Shanghai Immunology Joint Symposium (April 2014, Invited Speaker)

Oral presentation: The negative loop of VEGFR-3/VEGF-C in macrophages to restrain TLR4-NF-B pathway

3.    The 12th Cross-Strait Symposium on Biomedical Research, Shanghai (Sept 2013, Section Chair)

Oral presentation: Immune adaptor ADAP enhance PD-1 expression to reduce CTL-mediated anti-tumor response

4.    Frontiers of Immunology in Health and Diseases, Cold Spring Harbor, Suzhou (Sept 2012)

5.    The 11th Cross-Strait Symposium on Biomedical Research, Taiwan (June 2012)

Oral presentation: Signaling proteins PD1 and SKAP55 mediate the cytotoxicity of CD8+ CTLs

6.    4th SinoFinn Life Science Forum, Finland (August 2011)

Oral presentation: TCR induced integrin adhesion via 'insideout' signaling

7.    14th International Congress of Immunology, Kobe, Japan (2010)

Oral presentation: SKAP1-RapL regulate TCR ‘inside-out’ signalling and T-cell motility in lymph node

3. European Immunology Congress, Berlin, Germany (Sept. 2009)

Oral presentation and Poster: LFA-1 in ‘inside-out’ and ‘outside-in’ signaling.

4. Cambridge Institute for Medical Research retreat, Wellcome Trust Center, Cambridge, UK (March 2009)

Oral presentation: Adaptor proteins in ‘inside-out’ and ‘outside-in’ signaling

5. Cambridge Immunology Forum, Cambridge, UK (Sept. 2008)

6. Keystone meeting ‘Lymphocyte activation and signaling’, Snowbird, USA (2008):

Oral presentation: Sumolation of SLP-76 in the regulation of T-cell activation and microcluster formation &

Poster: SKAP-55 is an effecter in the ADAP-SKAP-55 module that regulates TcR induced integrin adhesion and T-cell activation

7. Cambridge Institute for Medical Research retreat, Wellcome Trust Center, Cambridge, UK (2008)

Poster: ADAP-SKAP-55 module in TcR induced inside-out signaling

8. 18th UK adhesion meeting (Cambridge, 2007):

Poster: ADAP-SKAP55 module regulates TcR induced cell activation and adhesion

9. Genetic control of T cell activation 2005 (Lofoten, Oslo, Norway):

Oral presentation: SLP-76-ADAP-SKAP-55 links TcR/CD3 complex to integrin clustering and costimulation

10. Selected to attend EMBO workshop 2004 (Italy):

Poster: ADAP-SLP-76 Binding Differently Regulates the Supramolecular Activation Complex (SMAC) Formation vs. Conjugate Formation

11. 12th International Congress of Immunology and 4th Annual Conference of FOCIS, Montreal, Canada, 2004:

Poster: ADAP-SLP-76 interaction regulates IL-2 production and Immunological Synapse formation

12. 2003 British Society of Immunology (BSI), UK:

Poster: Adaptors SLP-76 and ADAP are needed for LFA-1 localization in the Supramolecular Activation Complex (SMAC)

13. 2002 British Society of Immunology (BSI), UK:

Oral presentation: SKAP-55 regulates integrin adhesion and T cell-APC conjugation