葛高翔研究员

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 383

葛高翔 博士

中国科学院上海生命科学研究院生物化学与细胞生物学研究所、研究员 、博士生导师

出生年月:1975.05

办公地点:上海市岳阳路320号新生化大楼1415

电话:021-54921102

Email: gxge@sibcb.ac.cn

教育背景

1996-2001博士,中国科学院上海生物化学研究所

1992-1996学士,南京大学生物化学系

工作经历

2007-至今 研究员,中国科学院上海生命科学研究院生物化学与细胞生物学研究所

2002-2007 研究助理/Scientist,美国威斯康星大学麦迪逊分校病理系

2001-2002 博士后,美国田纳西大学药理系

学术奖项与活动

2011   Sanofi-SIBS Young Faculty Award

2010  中科院上海分院第二届杰出青年科技创新人才提名奖

2008   中科院“百人计划”

2006   美国生物化学与分子生物学学会年会旅行奖

2002 美国心脏学会博士后研究基金

研究方向

微环境在机体平衡调控与疾病发生发展过程中的功能研究

1)胞外基质:组织发育及恶性肿瘤发生过程中胞外基质动态重塑及其作用机制。

2)癌症相关成纤维细胞:肿瘤发展过程中成纤维细胞的活化,癌症相关成纤维细胞如何调控肿瘤细胞的生长及转移。

主持课题

1)自然科学基金委面上项目,赖氨酰氧化酶的调控与功能研究,2014-2017年,课题负责人。

2)自然科学基金委面上项目,Lysyl Oxidase在肿瘤转移中的作用机制研究,2010-2012年,课题负责人。

3)自然科学基金委重点项目,IV型胶原蛋白在肿瘤发生发展中的功能与机制研究,2015-2019年,课题负责人。

4)自然科学基金委重大项目,微环境-细胞交互作用诱导细胞迁移的信号转导机理,2012-2016年,课题骨干。

5)蛋白质重大研究计划,细胞生长调控的重要蛋白质群的功能与作用机制-细胞生长过程细胞骨架可塑性的调控机制,2010-2014年,课题骨干。

6)中国科学院知识创新工程重大项目,癌症重大科学问题及防治新策略的研究, 2009-2011年,课题骨干。

论文及论著

1.Cheng T, Liu Q, Zhang R, Zhang Y, Chen J, Yu R, Ge G#. (2014) Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation. J Mol Cell Biol. Epub ahead of print.

2.Chen C, Wang X, Xiong X, Liu Q, Huang Y, Xu W, Hu J, Ge G, Ling K. (2014) Targeting Type Iγ phosphatidylinositol phosphate kinase inhibits breast cancer metastasis. Oncogene. In press.

3.Jiang Y, Zhao X, Xiao Q, Liu Q, Ding K, Yu F, Zhang R, Zhu T, Ge G#. (2014) Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition. J Mol Cell Biol. 6, 352-4.

4.Han X, Li F, Fang Z, Gao Y, Li F, Fang R, Yao S, Sun Y, Li L, Zhang W, Ma H, Xiao Q, Ge G, Fang J, Wang H, Zhang L, Wong KK, Chen H, Hou Y, Ji H. (2014) Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma. Nat Commun. 5, 3261

5.Xiao Q, and Ge G#. (2012) Lysyl Oxidase, Extracellular Matrix Remodeling and Cancer Metastasis. Cancer Microenviron. 5, 261-73

6.Xiao G, Deng A, Liu H, Ge G, and Liu, X. (2012) Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1. Proc Natl Acad Sci U S A. 109, 15419-24

7.Sun H, Wu Y, Qi J, Pan Y, Ge G, and Chen J. (2011) The CC' and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low- and high-affinity integrin 47. J Biol Chem. 286, 12086-12092

8.Gao Y, Ge G, Ji H.(2011) LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor. Protein Cell. 2, 99-107

9.Huang G*, Ge G*, Wang D*, Gopalakrishnan B, Butz DH, Colman RJ, Nagy A, Greenspan DS. (2011) α3(V) Collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues. J Clin Invest. 121, 769-783

10.Gao Y, Xiao Q, Ma H, Li L, Liu J, Feng Y, Fang Z, Wu J, Han X, Zhang J, Sun Y, Wu G, Padera R, Chen H, Wong KK, Ge G#, Ji H#. (2010) LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling. Proc Natl Acad Sci U S A. 107:18892-7

11.Huang G, Zhang Y, Kim B, Ge G, Annis DS, Mosher DF, Greenspan DS. (2009) Fibronectin binds and enhances the activity of bone morphogenetic protein 1. J Biol Chem. 284(38):25879-88

12.Kobayashi K, Luo M, Zhang Y, Wilkes DC, Ge G, Grieskamp T, Yamada C, Liu TC, Huang G, Basson CT, Kispert A, Greenspan DS, Sato TN. (2009) Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat Cell Biol. 11(1):46-55.

13.Le Goff C, Morice-Picard F, Dagoneau N, Wang LW, Perrot C, Crow YJ, Bauer F, Flori E, Prost-Squarcioni C, Krakow D, Ge G, Greenspan DS, Bonnet D, Le Merrer M, Munnich A, Apte SS, Cormier-Daire V. (2008) ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation. Nat Genet. 40(9):1119-23.

14.Song W, Wu J, Ge G, Lin Q. (2008) Two domains of the epidermal growth factor receptor are involved in cytoskeletal interactions. Biochem Biophys Res Commun. 370(4):589-93.

15.Ge G, Fernández CA, Moses, MA and Greenspan DS. (2007) Bone Morphogenetic Protein 1 Processes Prolactin to a 17kDa Anti-Angiogenic Form. Proc Natl Acad Sci U S A. 104(24):10010-5.

16.Jasuja R, Ge G, Voss N, Lyman-Gingerich J, Branam AB, Pelegri F and Greenspan DS. (2007) Bone Morphogenetic Protein 1 Prodomain Specifically Binds, Localizes and Regulates Signaling of Bone Morphogenetic Proteins 2 and 4. J Biol Chem, 282(12):9053-62.

17.Zhang Y*, Ge G* and Greenspan DS. (2006) Inhibition of bone morphogenetic protein 1 by native and altered forms of α2-macroglobulin. J Biol Chem, 281: 39096-39104.

18.Ge G and Greenspan DS. (2006) BMP1 controls TGFβ1 activation via cleavage of latent TGFβ-binding protein. J Cell Biol, 175(1):111-120.

19.Jasuja R, Voss N, Ge G, Hoffman GG, Lyman-Gingerich J, Pelegri F and Greenspan DS. (2006) bmp1 and mini fin are functionally redundant in regulating formation of the zebrafish dorsoventral axis. Mech Dev, 123:548-558.

20.Wang WM, Ge G, Lim NH, Nagase H and Greenspan DS. (2006) TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2. Biochem J, 398:515-519.

21.Ge G and Greenspan DS. (2006) Developmental roles of the BMP1/TLD metalloproteinases. Birth Defects Res C Embryo Today, 78:47-68. (Invited Review)

22.Ge G, Zhang Y, Steiglitz BM and Greenspan DS. (2006) Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains. J Biol Chem, 281:10786-10798.

23.Ge G, Hopkins DR, Ho WB and Greenspan DS. (2005) GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cells. Mol Cell Biol, 25:5846-5858.

24.Ge G*, Seo NS*, Liang X, Hopkins DR, Hook M and Greenspan DS. (2004) Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis. J Biol Chem, 279:41626-41633.

25.Ge G, Wu J, Wang Y, and Lin Q. (2002) Activation mechanism of solubilized epidermal growth factor receptor tyrosine kinase. Biochem Biophy Res Commun, 290, 914-920

26.Ge G, Wu J, and Lin Q. (2001) Effect of membrane fluidity on tyrosine kinase activity of reconstituted epidermal growth factor receptor. Biochem Biophy Res Commun, 282, 511-514