周荣斌教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 656

周荣斌(男)

中国科学技术大学教授、微尺度国家实验室(筹)研究员,博士生导师。2012年入选中科院“百人计划”,并获基金委“优秀青年基金”支持。2002年毕业于中国科学技术大学生命科学学院,获学士学位;2002年至2007年在科大生科院进行研究生学习,获得细胞生物学博士学位;20077月至20113月,在瑞士洛桑大学进行博士后研究;20113月加入中国科学技术大学生命科学学院。

主要从事固有免疫细胞识别和信号转导机制研究,在固有免疫失调极炎症发生和调控及其致病机制研究方面做出过一系列工作。至今在《Nature》、《Cell》、《Science》、《Nat. Immunol》、《Immunity》、《J Exp Med》、《PNAS》等国际核心杂志上发表了SCI论文多篇,其中通讯作者或第一作者的SCI论文9篇。SCI论文总被引用1400余次,其中第一作者单篇最高引用400余次。现主持的科研项目包括基金委优秀青年基金、中科院“百人计划”项目、基金委重点项目、青年973项目等。

代表性论文(*Co-corresponding author, ? Co-first authorship

1.   Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z*, Zhou R*. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell. 2015 Jan 15;160(1-2):62-73.

2.   Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z*, Zhou R*. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol. 2014 ;15(12):1126-33.

3.   Jiang W, Wang X, Zeng B, Liu L, Tardivel A, Wei H, Han J, MacDonald HR, Tschopp J, Tian Z*, Zhou R*. Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. J Exp Med. 2013;21;210(11):2465-76.

4.   Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z*, Tschopp J, Zhou R*. ω-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013;27;38(6):1154-63.

5.   Zhou R, Yazdi A, Menu P,Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011 Jan 13;469(7329):221-5

6.   Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol. 2010 Feb;11(2):136-40.

7.   Schroder K, Zhou R, Tschopp J. The NLRP3 inflammasome: a sensor for metabolic danger? Science. 2010 Jan 15;327(5963):296-300.

8.   Zhou R, Wei H, Sun R, Zhang J, Tian Z. NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7512-5.

9.   Zhou R, Wei H, Sun R, Tian Z. Recognition of double-stranded RNA by TLR3 induces severe small intestinal injury in mice. J Immunol. 2007 Apr 1;178(7):4548-56.

10. Zhou R, Wei H, Tian Z. NK3-like NK cells are involved in protective effect of polyinosinic-polycytidylic acid on type 1 diabetes in nonobese diabetic mice. J Immunol. 2007 Feb 15;178(4):2141-7

11. Hou X, Zhou R, Wei H, Sun R, Tian Z. NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis. Hepatology. 2009 Mar;49(3):940-9.

12. Jiang W, Sun R, Zhou R, Wei H, Tian Z. TLR-9 activation aggravates concanavalin A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells. J Immunol. 2009 Mar 15;182(6):3768-74.