白丽教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 463

Li Bai                                                                                              

Professor, Institute of Immunology

The CAS Key Laboratory of Innate Immunity and Chronic Disease                                                        

Hefei National Laboratory for Physical Sciences at Microscale

School of life science

University of Science & Technology of China

Tel: 0551-3607897

Email: baili@ustc.edu.cn

Education

1997-2001: B.A., Biology, Huazhong University of Science and Technology, Wuhan, China

2001-2006: Ph.D., Biophysics, Huazhong University of Science and Technology, Wuhan, China

Research Experience

2001-2004: Ph.D. candidate, Huazhong University of Science and Technology, Wuhan, China

2004-2006: Ph.D. candidate, Institute of Biophysics, CAS, Beijing, China

2006-2010: Postdoctoral Fellow, Howard Hughes Medical Institute, University of Chicago, Chicago, USA

2010-PresentProfessor, University of Science and Technology of China, Hefei, China

Research Interests

Immune regulatory function of NKT cell.

NKT cell and meta-inflammation.

Publications

1.   Cui K, Yan G, Xu C, Chen Y, Wang J, Zhou R, Bai L, Lian Z, Wei H, Sun R, Tian Z. Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice. J Hepatol. 2015 Jan 9. pii: S0168-8278(14)00956-8.

2.   Zhu K, Yang J, Luo K, Yang C, Zhang N, Xu R, Chen J, Jin M, Xu B, Guo N, Wang J, Chen Z, Cui Y, Zhao H, Wang Y, Deng C, Bai L, Ge B, Qin CF, Shen H, Yang CF, Leng Q. TLR3 Signaling in Macrophages Is Indispensable for the Protective Immunity of Invariant Natural Killer T Cells against Enterovirus 71 Infection. PLoS Pathog. 2015 Jan 23;11(1):e1004613.

3.   Chen J, Wei Y, He J, Cui G, Zhu Y, Lu C, Ding Y, Xue R, Bai L, Uede T, Li L, Diao H. Natural killer T cells play a necessary role in modulating of immune-mediated liver injury by gut microbiota. Sci Rep. 2014 Dec 1;4:7259.

4.   Deng S, Bai L, Reboulet R, Matthew R, Engler DA, Teyton L, Bendelac A, Savage PB. A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo. Chem Sci. 2014 Apr; 5(4):1437-1441.

5.   Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ.Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells. Immunity. 2013 Dec 12;39(6):1032-42.

6.   Bai L*, Deng SL* , Reboulet R*, Mathew R , Teyton L, Savage PB , Bendelac A. Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16097-102.co-corresponding

7.   Bai L*, Picard D*, Anderson B, Chaudhary V, Luoma A, Jabri B, Adams EJ, Savage PB, Bendelac A. The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR. Eur J Immunol. 2012 Jul 25.

8.   Bai L, Constantinides MG, Thomas SY, Reboulet R, Meng F, Koentgen F, Teyton L, Savage PB, Bendelac A. Distinct APCs explain the cytokine bias of α-galactosylceramide variants in vivo. J Immunol. 2012 Apr 1;188(7):3053-61. Epub 2012 Mar 5co-corresponding.

9.   Deng S, Mattner J, Zang Z, Bai L, Teyton L, Bendelac A, Savage PB. Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids. Org Biomol Chem. 2011 Oct 26;(22):7659-62.

10. Scanlon ST, Thomas SY, Ferreira CM, Bai L, Krausz T, Savage PB, Bendelac A. Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation. J Exp Med. 2011 Sep 26;208(10):2113-24

11. Bai L, Sagiv Y, Liu Y, Freigang S, Yu KO, Teyton L, Porcelli SA, Savage PB, Bendelac A. Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen ?GC. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10254-9.

12. Zhao P, Yang L, Lopez JA, Fan J, Burchfield JG, Bai L, Hong W, Xu T, James DE. Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes. J Cell Sci. 2009 Oct 1;122(Pt 19):3472-80.

13. Liu Y, Deng S, Bai L, Freigang S, Mattner J, Teyton L, Bendelac A, Savage PB. Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties. Bioorg Med Chem Lett. 2008. 18:3052-5

14. Jiang L*, Fan J*, Bai L*, Wang Y, Chen Y, Yang L, Chen L, Xu T. Direct Quantification of Fusion Rate Reveals a Distal Role for AS160 in Insulin-stimulated Fusion of GLUT4 Storage Vesicles. J Biol Chem. 2008 Mar 28; 283(13): 8508-16.

15. Yuval Sagiv, Li Bai, Datsen G. Wei, Reuven Agami, Paul B. Savage, Luc Teyton, and Albert Bendelac. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J Exp Med. 2007 Apr 2.

16. Bai L*, Wang Y*, Fan J*, Chen Y, Ji W, Qu A, Xu P, James DE, Xu T. Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action.       Cell Metab. 2007 Jan; 5(1): 47-57.

17. Bai L*, Dan Zhu*, Keming Zhou*, Wei Zhou, Dongdong Li, Yan Wang, Rongying Zhang and Tao Xu. Differential properties of GTP- and Ca2+-stimulated exocytosis from large dense core vesicles. Traffic. 2006 Apr; 7(4): 416-28.

18. Li CH*, Bai L*, Li DD, Xia S, Xu T. Dynamic tracking and mobility analysis of single GLUT4 storage vesicle in live 3T3-L1 cells. Cell Res. 14(6), (2004),480-6.

19. Xia S, Kjaer S, Zheng K, Hu PS, Bai L, Jia JY, Rigler R, Pramanik A, Xu T, Hokfelt T, Xu ZQ. Visualization of a functionally enhanced GFP-tagged galanin R2 receptor in PC12 cells: constitutive and ligand-induced internalization. Proc Natl Acad Sci U S A. 101(42), (2004), 15207-12.

20. Xia S, Xu L, Bai L, Xu ZQ, Xu T. Labeling and dynamic imaging of synaptic vesicle-like microvesicles in PC12 cells using TIRFM. Brain Res. 997 (2), (2004), 159-64.

* These authors contributed equally to the work.