廉哲雄教授

文章出处: 作者: 发布时间: 2015-02-13 访问次数: 849

廉哲雄,Ph.D.

教授,博士生导师。教育部“长江学者”特聘教授,中科院“百人计划”获得者。

电话:0551-63600620   传真:0551-63600620

Email:  zxlian1@ustc.edu.cn

实验室网站:http://lianlab.ustc.edu.cn/wordpress

教育及工作经历

1989             白求恩医科大学(现吉林大学白求恩医学部)医学学士学位

1998             日本大阪关西医科大学医学博士

2000-2003   美国加州大学戴维斯分校(UCDavis)临床免疫学博士后

1989-1992 长春生物制品研究所实习研究员

1992-1994 日本大阪关西医科大学病理教研室研究员

1998-2000 美国纽约北岸大学医院小儿科助理研究员

2003-2007 美国加州大学戴维斯分校(UCDavis)内科资深研究员

2007-2009 美国加州大学戴维斯分校(UCDavis)内科副教授

2009-至今中国科技大学生命科学学院/免疫所教授、博士生导师

 

学术奖项与活动

1997 Kansai Medical University International Scholar Award

2009 中国科学院海外引进人才“百人计划“

2009 教育部长江学者特聘教授

2010 中国科技大学唐仲英讲席教授

2011 安徽省”百人计划“特聘专家

2003-至今   The American Association of Immunologisits (美国免疫学会会员)。

2010-至今   Journal of Autoimmunity 编委;

2013-至今   Scientific Reports 编委; 

 

研究方向

1)自身免疫性肝病的细胞和分子生物学发病机制

2)自身免疫性肠炎的细胞和分子生物学发病机制

3)开发新一代治疗自身免疫性疾病的靶点免疫药物

主持的课题

国家自然科学基金面上项目,(20101-201212月)负责人,

科技部973项目,(20101-201412月)课题骨干,

国家自然科学基金重点项目,(20121-201612月)负责人,

科技部973项目,(20131-201712月)课题骨干,

国家自然科学基金重点项目,(20151-201912月)负责人, 

 

代表性论文

1.   Zhang Y, Yasumizu R, Sugiura K, Hashimoto F Amoh Y, Lian Z, Cherry, Nishio N and Ikehara S. (1994) Fate of allogeneic or syngeneic cells in intravenous or portal vein injection: possible explanation for the mechanism of tolerance induction by portal vein injection. Eur. J. Immunology. 24: 1558-1565.

2.   Hayashi H, Toki J, Lian Z, Inoue K and Ikehara S. (1997) Analysis extrathymic T cell differentiation in nu/nu mice by mice by grafting embryonal organs. Immunology.197: 1-15.

3.   Lian Z, Toki J, Yu C, Hayashi H, Yasumizu R, Sugiura K, Jin T, Inaba M,Hisha H, Li Y, YU W, Fan H and Ikehara S. (1997) Intra-thymically injected pluripotent hemopoietic stem cells can differentiate into all lineage cells in the thymus. Stem cells. 15: 430-436.

4.   Yu C, Hisha H, Li Y, Lian Z, Toki J, Adachi Y, Inaba M, Fan T, Jin T, Iguchi T, Sogo S, Hosaka N, Song T, Xing J and Ikehara S. (1998) Stimulatory effects of hepatocyte growthfactor on hemopoiesis of SCF/c-kit system-deficient mice. Stem cells. 16: 66-77.

5.   Lian Z, Feng B, Sugiura K, Inaba M, Yu C, Jin T, Fan T, Cui Z, Yasumizu R, Toki J, Adachi Y, Hisha H and Ikehara S. (1999) c-kit<low pluripoietic stem cells form CFU-S on day 16. Stem cells. 17: 39-44.

6.   Feng B, Inaba M, Lian Z, Cui Y, Toki J, Ito T, Jin T, Fan T, Yang G, Yu C and Ikehara S. (2000) Deveolpment of mouse dendritic cells from lineage-negative c-kit<low pluripotent hemopoietic stem cell in vitro. Stem Cells. 18: 53-60.

7.   Hayashi H, Toki J, Lian Z, Sugiura K, Inoue K and Ikehara S. (2000) Long term (>1 year) analysis of chimerism and tolerance in mixed allogenic chimeric mice using normal mouse combinations. Stem Cells. 18: 273-80.

8.   Li Y, Hisha H, Inaba M, Lian Z, Yu C, Kawamura M, Yamamoto Y, Nishio N, Toki J, Fan H and Ikehara S. (2000) Evidence for migration of donor bone marrow stromal cells into recipient thymus after bone marrow transplantation plus bone grafts: A role of stromal cells in positive selection. Experimental Hematology. 28: 950-960.

9.   Morita H, Sugiura K, Inaba M, Jin T, Ishikawa J, Lian Z, Adachi Y, Sogo S, Yamanishi K, Taki H, Adachi M, Noumi T, Kamoyama Y, Good R and Ikehara (1998) A strategy for organ allografts without using immunosuppressants or irradiation. Proc Natl Acad Sci USA. 95: 6947-6952.

10. Fan T-X, Hisha H, Jin T-N, Yu C-Z, Lian Z-X, Guo S-B, Cui Y-Z, Feng B, Yang G-X, Li Q and Ikehara S. (2001) Successful allogeneic bone marrow transplantation (BMT) by injection of bone marrow cells via portal vein: stromal cells as BMT-Facilitating cells. Stem Cells. 19: 144-150.

11. Jin T, Toki J, Inaba M, Sugiura K, Fan T, Yu C, Lian Z, Takase K, Feng B, Ito T, Cui Y, Yang G and Ikehara S. (2001) A novel strategy for organ allografts using sublethal (7 Gy) irradiation followed by injection of donor bone marrow cells via portal vein. Transplantation. 71: 1725-1731.

12. Kita H, Lian Z-X, Van de Water J, He X-S, Matsumura S, Kaplan M, Luketic V, Coppel R, Ansari A.A, Gershwin ME. (2002) Identification of HLA-A2-restricted CD8+ Cytotoxic T Cell Responses in Primary Biliary Cirrhosis: T Cell Activation Is Augmented by Immune Complexes Cross-Presented by Dendritic Cells. J. Exp. Med.195: 113-123.

13. Kita H, Matsumura S, He X-S, Ansari AA, Lian Z-X, Van de Water J, Coppel RL, Kaplan M and Gershwin ME. (2002) Quantitative and functional Analysis of PDC-E2 Specific Autoreactive Cytotoxic T Lymphocytes in Primary Biliary Cirrhosis. J. Clinical Investigation. 109: 1231-1240.

14. Yang G, Hisha H, Cui Y, Fan T, Jin T, Li Q, Hosaka N, Lian Z and Ikehara S. (2002) A new assay method for late CFU-S formation and long-term reconstituting activity using a small number of pluripotent hemopoietic stem cells. Stem Cells. 20: 241-248.

15. Lian Z-X, Okada T, Kita H, Hsu T, Shultz L.D, Dorshkind K, Ansari A.A, Naiki M, Ikehara S and Gershwin ME. (2002) Impaired IL-7R Expression By B Lineage Cells In New Zealand Black (NZB) Mice. Stem Cells. 20: 293-300.

16. Lian Z-X, Kita H, Okada T, Hsu T, Shultz L.D, Dorshkind K, Ansari A.A, Ikehara S, Naiki M and Gershwin ME. (2002) Increased Frequency of Pre-Pro B cells in bone marrow of New Zealand Black (NZB) mice: Implications for a developmental block in B cell differentiation. Development Immunology. 9: 35-45.

17. Okada T, Lian Z-X, Hsu T, Naiki M, Ansari AA, and Gershwin ME. (2002) Elevated c-MET in thymic dendritic cells of New Zealand Black (NZB) mice. Development Immunology. 9: 27-34.

18. Kita H, Matsumura S, He X-S, Ansari AA, Lian Z-X, Van de Water J, Coppel RL, Kaplan M and Gershwin ME. (2002) Analysis of TCR antagonism and molecular mimicry of an HLA-A0201-restricted CTL epitope in primary biliary cirrhosis. Hepatology. 36: 918-926.

19. Matsumura S, Kita H, He X-S, Ansari AA, Lian Z-X, Van de Water J, Yamamoto K, Tsuji T, Coppel RL, Kaplan M and Gershwin ME. (2002) Comprehensive mapping of HLA-A0201-restricted CD8 T-cell epitopes on PDC-E2 in primary biliary cirrhosis. Hepatology. 36: 1125-1134.

20. Cui Y-Z, Hisha H, Yang G-X, Fan T, Jin T, Li Q, Lian Z and Ikehara S. (2002) Optimal protocol for total body irradiation for allogeneic bone marrow transplantation in mice. Bone Marrow Transplantation. 30: 843-849.

21. Lian Z-X, Okata T, He X-S, Kita H, Liu Y-J, Ansari AA, Kikuchi K, Ikehara S and Gershwin ME. (2003) Heterogenity of dendritic cells in the mouse liver: Identification and characterization of four distinct types. J. Immunology. 170: 2323-2330.

22. Okada T, Lian Z-X, Hsu T, Ansari AA, Naki M, Ikehara S and Gershwin ME. (2003) Murine thymic plasmacytoid dendritic cells and toll like receptor. Eur. J. Immunology. 33: 1012-1019.

23. Toki J, Adachi Y, Jin T, Fan T, Takase K, Lian Z, Hayashi H, Gershwin ME and Ikehara S. (2003) Enhancement of IL-7 Following Irradiation of Fetal Thymus. Immunobiology. 207: 247-258.

24. Kita H, Ansari AA, He X-S, Lian Z-X, Van de Water J, Coppel RL, Luketic V, Kaplan M, Inamori H, Isoda N, Sugano K, Imawari M, Gershwin ME. (2003) Proteasome is required for class I-restricted presentation by Fc receptor-mediated endocytosis in primary biliary cirrhosis. J. Autoimmunity. 21: 175-182.

25. Kikuchi K, Lian Z-X, He X-S, Ansari AA, Ishibashi M, Miyakawa H, Shultz LD, Ikehara S, Gershwin ME. (2003) Appearance of human plasma cells following differentiation of human B cells in NOD/SCID mouse spleen. Clin. Dev. Immunol. 10: 197-202.

26. Lian Z-X, Kikuchi K, Yang G-X, Ansari AA, Ikehara S and Gershwin ME. (2004) Expansion of Bone Marrow IFN-?-Producing Dendritic Cells in New Zealand Black (NZB) Mice: High Levels Expression of TLR9 and Secretion of IFN-a NZB Bone Marrow. J. Immunology. 173: 5283-5289.

27. Cheunsuk S, Lian Z-X, Yang,G-X, Gershwin ME, Gruen JR and Bowlus CL. (2005) Prss16 Is Not Required for T-cell Development. Mol. Cell. Biol. 25: 789-796.

28. Kikuchi K, Lian Z-X, Yang G-X, Ansari AA, Ikehara S, Kaplan M, Miyakawa H, Coppel RL and Gershwin ME. (2005) Bacterial CpG induces hyper-IgM production in CD27+ memory B cells in primary biliary cirrhosis. Gastroenterology. 128: 304-312.

29. Yang G-X*, Lian Z-X*, Kikuchi K, Liu Y-J, Ansari AA, Ikehara S and Gershwin ME. (2005) CD4- plasmacytoid dendritic cells (pDCs) migrate in lymph nodes by CpG inoculation and represent a potent functional subset of pDCs. J. Immunology. 174:3197-3203. (*Co-first author).

30. Kikuchi K, Lian Z-X, Kimura Y, Selmi C, Yang G-X, Coppel RL, Ansari AA, Ikehara S, Miyakawa H and Gershwin ME. (2005) Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis. J. Autoimmunity. 24: 347-352.

31. Lan RY, Ansari AA, Lian Z-X and Gershwin ME. (2005) Regulatory T cells: Development, Function and Role in Autoimmunity. Autoimmunity Review. 4: 351–363.

32. Mao Tin*, Lian Z-X*, Selmi C*, Ichiki Y, Watnik M, Ansari AA, Coppel RL,Shimoda S, Ishibashi H, and Gershwin ME. (2005) Altered innate immunity in patients with primary biliary cirrhosis. Hepatology. 42: 802-808. (*Co-first author).

33. Wang X-L, Hisha H, Taketani H, Inaba M, Song CY, Fan T-X, Cui Y-Z, Yang G-X, Li Q, Cui W-H, Guo K-Q, Fan H-X, Lian Z-X, Gershwin ME and Ikehara S. (2005) NCAM Contributes to Hemopoiesis-Supporting Capacity of Stromal Cells: Contribution of NCAM to Hemopoiesis. Stem Cells. 23:1389.

34. Chuang Y-H*, Lian Z-X*, Cheng C-M, Lan RY, Yang G-X, Moritoki Y, Chiang B-L, Ansari AA, Tsuneyama K, and Gershwin ME. (2005) Increased levels of chemokine receptor CXCR3 and chemokines IP-10 and MIG in patients with primary biliary cirrhosis and relative controls. J. Autoimmunity. 25: 126-132. (*Co-first author).

35. Yang G-X*, Lian Z-X*, Kikuchi K, Moritoki Y, Liu Y-J, Ansari AA, Ikehara S and Gershwin ME. (2005) Plasmacytoid dendritic cells of different origins have distinct characteristics and function: Studies of common lymphoid projections versus common myeloid progenitors. J. Immunology (2013 IF:5.52). 175: 7281-7287. (*Co-first author).

36. Lan RY, Cheng C, Lian Z-X, Tsuneyama K, Yang G-X, Moritoki Y, Chuang Y-H, Nakamura T, Saito S, Shimoda S, Tanaka A, Bowlus CL, Takano Y, Ansari AA, Coppel RL and Gershwin ME. (2006) Liver targeted and peripheral blood alterations of regulatory T cells in PBC. Hepatology. 43: 729-737.

37. Wang X-L, Hisha H, Teketani S, Adachi Y, Li Q, Cui W, Cui Y, Wang J, Song C, Mizokami T, Okazaki S, Fan T, Fan H, Lian Z-X, Gershwin ME, and Ikehara S. (2006) Characterization of Mesenchymal Stem Cells Isolated from Mouse Fetal Bone. Stem Cells. 24: 482-493.

38. Chuang Y-H*, Lian Z-X*, Tsuneyama K, Chiang B-L, Ansari AA, Coppel RL and Gershwin ME. (2006) Increased killing activity and decreased cytokine production in NK cells in patients with primary biliary cirrhosis. J. Autoimmunity. 26: 232-240. (*Co-first author).

39. Oertelt S*, Lian Z-X*, Cheng C-M, Chuang Y-H, Padgett KA, He X-S, Ridgway WM, Wicker LS, Ansari AA, Coppel RL, Li MO, Flavell RA, Mackay IR and Gershwin ME. (2006) Presence of anti-mitochondrial antibodies and autoimmune cholangitis in TGF-? Receptor II dominant-negative mice. J. Immunology. 177: 1655-1660 (*Co-first author).

40. Moritoki Y, Lian Z-X, Ohsugi Y, Ueno Y and Gershwin ME. (2006) B cells and autoimmune disease. Autoimmunity Review. 5: 449-457.

41. Aoki CA, Roifman CM, Lian Z-X, Bowlus CL, Norman GL, Shoenfeld Y, Mackay IR, Gershwin ME. (2006) IL-2 receptor alpha deficiency and features of primary biliary cirrhosis. J. Autoimmunity. 27: 50-53.

42. Wakabayashi K*, Lian Z-X*, Moritoki Y*, Lan RY, Tsuneyama K, Chuang Y-H, Yang G-X, Ridgway W, Ansari AA, Coppel RL, Mackay IR and Gershwin ME. (2006) IL2R?-/- mice and the development of primary biliary cirrhosis. Hepatology. 44:1240-1249 (*Co-first author).

43. Moritoki Y*, Lian Z-X*, Wulff H, Yang G-X, Chuang, Y-H, Lan RY, Ueno Y, Ansari AA, Coppel RL, Mackay IR and Gershwin ME. (2007) AMA production is promoted by bacterial CpG and suppressed by potassium channel blockers in Primary Biliary Cirrhosis (PBC). Hepatology. 45:314-322 (*Co-first author).

44. Okada T, Inaba M, Naiki M, Lian Z-X, Gershwin ME and Ikehara S. (2007) C-met mRNA elevation on thymic dendritic cells in autoimmune mice. J. Autoimmunity. 28:41-45.

45. Zeng C, Zhen Y, Shu S-A, Wu T, Yi H, Lian Z-X, and Zhao Y. (2007) Inhibition of B and T lymphocyte attenuator expression by immunosuppressive drug cyclosporin A. J. Autoimmunity. 28:234-244.

46. Shu S-A*, Lian Z-X*, Chuang Y-H, Yang G-X, Moritoki Y, Comstock SS, Zhong R-Q, Ansari AA, Liu Y-J and Gershwin ME. (2007) CD11c+ Hepatic Dendritic Cells in the induction of innate immune responses. Clinical Experimental Immunology. 149:335-343. (*Co-first author).

47. Yang G-X, Lian Z-X, Chuang Y-H, Shu S-A, Moritoki Y, Lan R, Wakabayashi K, Ansari AA, Dorshkind K, Ikehara S and Gershwin ME*. (2007) Generation of Functionally Distinct B Lymphocytes From Common Myeloid Progenitors. Clinical Experimental Immunology. 150:349-357.

48. Hsu W, Shu S-A, Gershwin ME and Lian Z-X*. (2007) The Current Immune Function of Hepatic Dendritic Cell (invited review). Cellular & Molecular Immunology. 4:321-328. (*Corresponding author).

49. Chuang Y-H, Lian Z-X*, Yang G-X, Shu S-A, Moritoki Y, Ridgway WM, Ansari AA, Kronenberg M, Flavell RA, Gao B and Gershwin ME. (2008) NKT cells exacerbate liver injury in a TGF-? receptor II dominant-negative mouse model of primary biliary cirrhosis. Hepatology. 47:571-580. (*Corresponding author).

50. Yang G-X, Lian Z-X*, Chuang Y-H, Moritoki Y, Lan R, Wakabayashi K, Ansari AA, Flavell R, Ridgway WM, Coppel RL, Tsuneyama K, Mackay IR and Gershwin ME*. (2008) Adoptive transfer of CD8+ T cells from dnTGF?RII mice induces autoimmune cholangitis into Rag1-/- mice. Hepatology. 47:1974-1982. (*Equally Corresponding author).

51. Wakabayashi K, Lian Z-X, Leung PS, Moritoki Y, Tsuneyama K, Kurth MJ, Lam KS, Yoshida K, Yang G-X, Hibi T, Ansari AA, Ridgway WM, Coppel RL, Mackay IR and Gershwin ME. (2008) Loss of tolerance in C57BL/6 mice to the autoantigen PDC-E2 by a xenobiotic with ensuing biliary ductular disease. Hepatology.47: 531-540.

52. Shi M, Adachi Y, Shigematsu A, Koike-Kiriyama N, Feng W, Yanai S, Cui Y, Lian Z-X, Li J and Ikehara S. (2008) Intra-Bone Marrow Injection of Donor Bone Marrow Cells Suspended in Collagen Gel Retains Injected Cells in Bone Marrow, Resulting in Rapid Hemopoietic Recovery in Mice. Stem Cells. 26:2211-6.

53. Wei H, Chuang Y-H, Li B, Wei H, Sun R, Moritoki Y, Gershwin ME, Lian Z-X* and Tian Z*. (2008) CD4+CD25+ regulatory T cells ameliorate liver injury via a TGF-β-dependent mechanism in Concanavalin A-induced hepatitis model. J. Immunology. 181:7221-9. (*Equally Corresponding author).

54. Hsu W, Zhang W, Tsuneyama K, Moritoki Y, Ridgway WM, Ansari AA, Lian Z-X*, Mackay IR, and Gershwin ME*. (2009) Differential Effector Mechanisms for the Pathogenesis of Autoimmune Cholangitis and Inflammatory Bowel Disease in Interleukin 2 Receptor ? Knockout Mice (IL-2R?-/-). Hepatology. 49:133-140. (*Equally Corresponding author).

55. Zhang W, Sharma R, Ju S-T, He X-S, Tao Y, Tsuneyama K, Tian Z, Lian Z-X*, Fu SM and Gershwin ME. (2009) Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis. Hepatology. 49:545-552. (*Equally Corresponding author).

56. Wakabayashi K, Yoshida K, Leung PS, Moritoki Y, Yang G-X, Tsuneyama K, Lian Z-X, Hibi T, Ansari AA, Wicker LS, Ridgway WM, Coppel RL, Mackay IR and Gershwin ME. (2009) Induction of autoimmune cholangitis in NOD.1101 mice following a chemical xenobiotic immunzation. Clinical Experimental Immunology. 155:577-86.

57. Moritoki Y, Zhang W, Tsuneyama K, Yoshida K, Wakabayashi K, Yang G-X, Bowlus C, Ridgway W, Ueno Y, Ansari AA, Coppel RL, Mackay IR, Flavell RA, Gershwin ME* and Lian Z-X*. (2009) B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology. 136:1037-1047. (*Equally Corresponding author).

58. Lan RY, Salunga TL, Tsuneyama K, Lian Z-X, Yang G-X, Hsu W, Moritoki Y, Ansari AA, Kemper C, Price J, Atkinson JP, Coppel RL and Gershwin ME. (2009) Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmunity. 32:43-51.

59. Park O, Wang L, Jeong W-I, Wang H, Lian Z-X, Gershwin ME and Gao B. (2009) Invariant NKT cells play a diverse role in acute liver injury but are depleted in chronic liver injury induced by CCl4. Hepatology. 49:1683-1694.

60. Zhang W, Moritoki Y, Tsuneyama K, Yang G-X, Ilan Y, Lian Z-X* and Gershwin ME*. (2009) ?-glucosylceramide Ameliorates Liver Inflammation in Murine Autoimmune Cholangitis. Clinical Experimental Immunology. 157:359-364. (*Equally Corresponding author).

61. Yoshida K, Yang G-X, Zhang W, Tsuda M, Tsuneyama K, Moritoki Y, Ansari AA, Okazaki K, Lian Z-X*, Coppel RL, Mackay I and Gershwin ME*. (2009) Deletion of IL-12p40 suppresses autoimmune cholangitis in dnTGFβRII mice. Hepatology. 50:1494-1500. (*Equally Corresponding author).

62. Lafdil F, Wang H, Park O, Zhang W, Moritoki Y, Yin S, Yuan X, Gershwin ME, Lian Z-X and Gao B. (2009) Myeloid STAT3 inhibits T-cell–mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production. Gastroenterology.137:2125–2135.

63. Moritoki Y*, Lian Z-X*, Lindor K, Tuscano J, Tsuneyama K, Zhang W, Ueno Y, Dunn R, Kehry M, Coppel RL, Mackay IR and Gershwin ME. (2009) B cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in dnTGF-?RII mice. Hepatology. 50:1893-1903. (*Co-first author).

64. Selmi C, Meda F, Kasangian A, Invernizzi P, Tian Z, Lian Z-X, Podda M and Gershwin ME. (2010) Experimental evidence on the immunopathogenesis of primary biliary cirrhosis. Cellular & Molecular Immunology. 7:1-10.

65. Zhang W, Tsuda M, Yang GX, Tsuneyama K, Rong G, Ridgway WM, Ansari AA, Flavell RA, Coppel RL, Lian Z-X, Gershwin ME. (2010) Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis. Hepatology. 52:252-222.

66. Shi M, Adachi Y, Cui Y, Li M, Lian Z, Zhang Y, Yanai S, Shima C, Imai Y and Ikehara S. (2010) Combination of intra-bone marrow–bone marrow transplantation and subcutaneous donor splenocyte injection diminishes risk of graft-versus-host disease and enhances survival rate. Stem Cells and Development. 20:759-68.

67. Yang G-X, Wu Y, Tsukamoto H, Leung PS, Lian Z-X, Rainbow DB, Hunter KM, Morris GA, Lyons PA,Peterson LB, Wicker LS, Gershwin ME, and Ridgway WM. (2011) CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease. J. Immunology. 186: 1259–1267.

68. Moritoki Y, Tsuda M, Tsuneyama K, Zhang W, Yoshida K, Lian Z-X, Yang GX, Ridgway WM, Wicker LS, Ansari AA and Gershwin ME. (2011) B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis. Cell Immunol. 268:16-23.

69. Agmon-Levin N, Lian Z-X, Shoenfeld Y. (2011) Explosion of autoimmune diseases and the mosaic of old and novel factors. Cellular & Molecular Immunology. 8:189-92.

70. Tsuda M, Ambrosini YM, Zhang W, Yang GX, Ando Y, Rong G, Tsuneyama K, Sumida K, Shimoda S, Bowlus CL, Leung PS, He XS, Coppel RL, Ansari AA, Lian Z-X and Gershwin ME. (2011) Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis. Hepatology. 54:1293-1302.

71. Tsuda M, Moritoki Y, Lian Z-X, Zhang W, Yoshida K, Wakabayashi K, Yang G-X, Nakatani T, Vierling J, Lindor K, Gershwin ME and Bowlus CL. (2011) Biochemical and immunologic effects of rituximab in primary biliary cirrhosis patients with an incomplete response to ursodeoxycholic acid. Hepatology. 55:512-521.

72. Jin Q, Moritoki Y, Lleo A, Tsuneyama K, Invernizzi P, Moritoki H, Kikuchi K, Lian Z-X, Hirschfield GM, Ansari AA, Coppel RL, Gershwin ME and Niu J. (2011). Comparative analysis of portal cell infiltrates in AMA positive versus AMA negative PBC. Hepatology. 55:1495-1506.

73. Shu SA, Ma HD and Lian Z-X*. (2012) Ontogenic Development and Population Dynamics of Hepatic Dendritic Cells. Current Immunology Reviews. 8:3-11. (Corresponding author).

74. Ando Y, Yang GX, Tsuda M, Kawada K, Zhang W, Nakajima T, Tsuneyama K, Leung P, Lian Z-X, Okazaki K, Ridgway WM, Norman GL, Ansari AA, He XS, Coppel RL and Gershwin ME. (2012) The immunobiology of colitis and cholangitis in IL-23p19 and IL-17A deleted dnTGFβRII mice. Hepatology. 56:1418-26

75. Zhang W, Tsuda M, Yang G-X, Tsuneyama K, He X-S, Ansari AA, Ridgway WM, Coppel RL, Lian Z-X, Leung P and Gershwin ME. (2012) Lymphoma-Like T Cell Infiltration in Liver Is Associated with Increased Copy Number of Dominant Negative Form of TGFb Receptor II. Plos One. 7: e49413.

76. Tsuda M, Zhang W, Yang GX, Tsuneyama K, Ando Y, Kawata K, Park O, Leung P, Coppel RL, Ansari AA, Ridgway WM, Gao B, Lian Z-X*, Flavell R, He XS and Gershwin ME*. (2013) Deletion of IL-12p35 induces liver fibrosis in dominant negative transforming growth factor β receptor type II mice. Hepatology. 57:806-16. (*Equally Corresponding author).

77. Ma HD, Deng YR, Tian Z and Lian Z-X*. (2013) Traditional Chinese Medicine and Immune Regulation. Clin Rev Allergy Immunol. 44:229-241. (Corresponding author).

78. Ando Y, Yang GX, Kenny TP, Kawata K, Zhang W, Huang W, Leung PS, Lian Z-X, Okazaki K, Ansari AA, He XS, Invernizzi P, Ridgway WM, Lu Q, Gershwin ME. (2013) Overexpression of microRNA-21 is associated with elevated pro-inflammatory cytokines in dominant-negative TGF-β receptor type II mouse. J Autoimmunity. 41:111-119.

79. Kawata K, Yang G-X, Ando Y, Tanaka H, Zhang W, Kobayashi Y, Tsuneyama K, Leung P, Lian Z-X, Ridgway WM, Ansari AA, He X-S, and Gershwin ME. (2013) Clonality, Activated Antigen Specific CD8+ T Cells and Development of Autoimmune Cholangitis in dnTGFβRII Mice. Hepatology. 58:1094-1104.

80. Deng Y-R, Ma H-D, Tsuneyama K, Yang W, Wang Y-H, Lu F-T, Liu C-H, Liu P, He X-S, Diehl AM, Gershwin ME and Lian Z-X*. (2013) STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib. J Autoimmunity. 49:25-34. (Corresponding author).

81. Sun H, Lv J, Tu Z, Hu X, Yan H, Pan Y, Xu D, Lian Z-X, Chi X and Niu J. (2013) Antiviral treatment improves disrupted peripheral B lymphocyte homeostasis in chronic hepatitis B virus-infected patients. Exp Bio Med. 238:1275-1283.

82. Deng Y-R, Yoshida K, Jin Q, Murata M, Yamaguchi T, Tsuneyama K, Moritoki Y, Niu J, Matsuzaki K and Lian Z-X*. (2014) Reversible phosphor-Smad3 signaling between tumor-suppression and fibro-carcinogenesis in chronic hepatitis B infection. Clinical Experimental Immunology. 176:102-111. (Corresponding author).

83. Yao Y, Yang W, Yang Y-Q, Ma H-D, Lu F-T, Li L, Tao Y-Y, Tsuneyama K, Zhang W, Friedman S, Gershwin ME and Lian Z-X*. (2014) Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Rα-/- mice. J Autoimmunity. 51:99-108. (Corresponding author).

84. Yang W, Yao Y, Yang Y-Q, Lu F-T, Li L, Wang Y-H, Nakajima T, Tsuneyama K, Ridgway WM, Gershwin ME and Lian Z-X*. (2014) Differential Modulation by IL-17A of Cholangitis Versus Colitis in IL-2R? Deleted Mice. Plos One. 9:e105351. (Corresponding author).

85. Tanaka H, Zhang W, Yang G-X, Ando Y, Tomiyama T, Tsuneyama K, Leung P, Coppel R, Ansari A, Lian Z-X, Ridgway W, Takashi j and Gershwin ME. (2014) Successful Immunotherapy of Autoimmune Cholangitis by Adoptive Transfer of Foxp3+ Regulatory T cells. Clinical Experimental Immunology. 178:253-61

86. Wang J, Li F, Wei, Lian Z-X, Sun R and Tian Z. (2014) Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation. J. Exp. Med. 211:2397-2410.

87. Ma H-D, Wang Y-H, Chang C, Gershwin ME and Lian Z-X*. (2014) The Intestinal Microbiota and Microenvironment in Liver. Autoimmunity Reviews. 14:183-191. (Corresponding author).