俞春东教授

文章出处: 作者: 发布时间: 2014-05-14 访问次数: 260

俞春东,Ph. D.

新世纪优秀人才,教授,博士生导师

炎症与肝病学

课题组组长

  话:+86-0592-2182013

E-mailcdyu@xmu.edu.cn 

教育及工作经历:

1993,中山大学生物学系生物化学专业,获理学学士学位;

1996,厦门大学生物学系细胞生物学专业,获理学硕士学位;

2002,美国德州大学休士顿健康科学中心细胞生物学专业,获博士学位;

2002年至2006,美国贝勒医学院Bert OMalley实验室,博士后研究工作;

2006至今,厦门大学生命科学学院教授,博士生导师,炎症与肝病学课题组组长。

研究领域

炎症与肝病学课题组主要从事生物医学的理论和应用基础研究。本课题组主要有两个研究方向:第一,研究核受体及其转录协同因子在炎症反应的发生、发展以及其在炎症反应相关疾病发病中的作用。第二,研究核受体及其转录协同因子在肝脏代谢及肝损伤、肝纤维化和肝癌等肝脏疾病发病中的作用。

代表性论文:

1. Zhu, J., Chen, Q., Xia, X., Mo, P., Shen, Y., Yu, C.*. Mycoepoxydiene Suppresses RANKL-induced Osteoclast Differentiation And Reduces Ovariectomy-induced Bone Loss in Mice. Appl Microbiol Biotechnol. 97(2):767-774, 2013.

2. Liu Y, Tong Z, Li T, Chen Q, Zhuo L, Li W, Wu R-C, Yu C*. Hepatitis B virus X Protein Stabilizes Amplified in Breast Cancer 1 Protein and Cooperates with It to Promote Human Hepatocellular Carcinoma Cell Invasiveness. Hepatology. 56:1015-1024, 2012.

3. Chen Q, Li W, Wan Y, Xia X, Wu Q, Chen Y, Lai Z, Yu C*, Li W*. Amplified in Breast Cancer 1 Enhances Human Cholangiocarcinoma Growth and Chemoresistance by Simultaneous Activation of Akt and Nrf2 Pathways. Hepatology. 55:1820-1829, 2012.

4. Chen T, Chen Q, Xu Y, Zhou Q, Zhu J, Zhang H, Wu Q, Yu C*. Steroid Receptor Coactivator 3 Is Required for CAR-regulated Hepatocyte Proliferation and Drug Metabolism. Journal of Hepatology. 56:210-217, 2012.

5. Chen Q, Chen T, Li W, Zhang W, Zhu J, Li Y, Huang Y, Shen Y*, Yu C*. Mycoepoxydiene Inhibits Lipopolysaccharide-Induced Inflammatory Responses through the Suppression of TRAF6 Polyubiquitination. PLoS One. 7:e44890, 2012.

6. Chen Q, Chen T, Xu Y, Zhu J, Jiang Y, Zhao Y, Xu J, Yu C*. Steroid Receptor Coactivator 3 Is Required for Clearing Bacteria and Repressing Inflammatory Response in Escherichia coli-induced Septic Peritonitis. The Journal of Immunology. 185: 5444-5452, 2010.

7. Xu Y, Chen Q, Li W, Su X, Chen T, Liu Y, Zhao Y, Yu C*. Overexpression of Transcriptional Coactivator AIB1 Promotes Hepatocellular Carcinoma Progression by Enhancing Cell Proliferation and Invasiveness. Oncogene. 29: 3386-3397, 2010.

8. Chen Q, Zhao Y, Cheng Z, Xu Y, Yu C*. Establishment of A Cell-based Assay for Examining the Expression of Tumor Necrosis Factor Alpha (TNF-alpha) Gene. Applied Microbiology and Biotechnology. 80: 357-363, 2008.

9. Yu C, York B, Wang S, Feng Q, Xu J, O’Malley B. An Essential Function of the SRC-3 Coactivator in Suppression of Cytokine mRNA Translation and Inflammatory Response. Molecular Cell. 25: 765-778, 2007.

荣誉、奖励及参加学术团体的情况:

1. 2010年教育部新世纪优秀人才支持计划入选者

2. 2010年福建省自然科学基金杰出青年基金获得者