尤涵教授

文章出处: 作者: 发布时间: 2014-05-14 访问次数: 794

涵,Ph.D.

新世纪优秀人才,教授,博士生导师

课题组组长

  话:+86-592-2180113

E-mailyouhanbu@hotmail.com

hyou@xmu.edu.cn

教育及工作经历:

1999年,第四军医大学七年制本硕联读临床医疗专业,获得医学学士与硕士学位;

20027月,第四军医大学,博士学位.

20003-20016月,波士顿大学生化系,访问学生;

20017-20038月,麻省理工学院肿瘤研究中心,访问学者;

20039-20077月,加拿大多伦多大学,博士后;

20078-至今,厦门大学生命科学学院,教授、 博士生导师。

研究领域

胰岛素信号通路对应激刺激的调控及在衰老和衰老相关疾病中的功能,以及该通路与其他信号通路之间的相互应答。鉴定调控细胞周期,细胞分化,细胞凋亡,细胞自噬的关键分子和信号通路,并阐明其分子机理。

代表性论文:

1. Zhang L, Mei Y, Fu N Y, Guan L, Xie W, Liu H H, Yu C D, Yin Z, Yu V C, and You H*.  TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. Proc Natl Acad Sci USA. 2012 Dec;  109(51), 20937-20942,. (*corresponding author)

2. Zhang Y, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak TW, You H*. Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1. Proc Natl Acad Sci USA. 2012 April; 109(15): 5717-5722 (*corresponding author)

3. Mei Y, Wang Z, Zhang L, Zhang Y, Li X, Liu H, Ye J, You H*. Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA. Proc Natl Acad Sci USA. 2012 March; 109(13): 4898-4903 (*corresponding author)

4. Hao Z, Duncan GS, Su YW, Li WY, Silvester J, Hong C, You H, Brenner D, Gorrini C, Haight J, Wakeham A, You-Ten A, McCracken S, Elia A, Li Q, Detmar J, Jurisicova A, Hobeika E, Reth M, Sheng Y, Lang PA, Ohashi PS, Zhong Q, Wang X, Mak TW. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.J Exp Med. 2012 Jan 16;209(1):173-86.

5. Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H*, Kwiatkowski D, Zhang H*. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci U S A., 2011, 108(10):4129-34. (*co-corresponding author)

6. Mei Y, Zhang YR,Yamamoto K, Xie W, Mak TW*, You H*. FOXO3a-dependent regulation of Pink1/Park6 mediates survival signaling in response to cytokine deprivation. Proc Natl Acad Sci U S A., 2009, 106(13):5153-8. (*co-corresponding author) Sci. Signal., EDITORS' CHOICE: Cell Survival In the Pink1 with FOXO3a. 2009, Vol. 2, Issue 65