杨云青教授

文章出处: 作者: 发布时间: 2014-05-14 访问次数: 500

 

杨云青,PhD

教授,博士生导师

分子医学课题组组长

电话/传真:+86-592-2187230

电邮:jamesyang@xmu.edu.cn

教育及工作经历:

厦门大学微生物学学士;

美国德州休士顿大学生化与分子生物学博士;

1994-1998, 美国哥伦比亚大学, NIH博士后/副研究员;

1998-2005, 香港大学分子生物研究所/生理系, 研究助理教授/研究员;

2006–现今,细胞应激生物学国家重点实验室/厦门大学生命科学学院教授

研究领域

细胞应激蛋白、核/激素受体、转录因子以及microRNAs在高盐、高渗、高糖、氧化胁迫、环境毒素和异生物质胁迫等细胞应激反应以及糖尿病和糖尿病并发症、高血压、肿瘤等人类重大疾病中的作用与机制。

代表性论文:

1. Luo Y, Liu Y, Liu M, Wei J, Zhang Y, Hou J, Huang W, Wang T, Li X, He Y, Ding F, Yuan L, Cai J, Zheng F, Yang JY* (2014) Sfmbt2 10th intron-hosted miR-466(a/e)-3p are important epigenetic regulators of Nfat5 signaling, osmoregulation and urine concentration in mice. BBA Gene Regul Mech (In press)

2. Luo Y, Kong F, Wang Z, Chen D, Liu Q, Wang T, Xu R, Wang X*, Yang JY* (2014) Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration. Mol Med Rep 9:387-394.

3. Wei J, Zhang Y, Luo Y*, Wang Z, Bi S, Song D, Dai Y, Wang T, Qiu L, Wen L, Yuan L*, Yang JY* (2014) Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1-Nrf2, Tgfbeta1/2, and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice. Free Radic Biol Med 67C:91-102.

4. Ji S, Ye G, Zhang J, Wang L, Wang T, Wang Z, Zhang T, Wang G, Guo Z, Luo Y, Cai J*, Yang JY* (2013) miR-574-5p negatively regulates Qki6/7 to impact beta-catenin/Wnt signalling and the development of colorectal cancer. Gut 62:716-726.

5. Liu Q, Luo Y, Li X, Yuan L, Xu R*, Yang JY* (2013) Preparation and Characterizations of Polyclonal Antibodies Against STAR Protein QKI7b. Appl Biochem Biotechnol 169:2273-2280.

6. Qiu L*, Lin J, Ying M, Chen W, Yang J, Deng T, Chen J, Shi D, Yang JY* (2013) Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis. PLoS One 8:e73591.

7. Zhou W, Miao Y, Zhang Y, Liu L, Lin J, Yang JY, Xie Y, Wen L (2013) Induction of cyto-protective autophagy by paramontroseite VO2 nanocrystals. Nanotechnology 24:165102.

8. Qiu L, Lin J, Xu F, Gao Y, Zhang C, Liu Y, Luo Y, Yang JY* (2012) Inhibition of aldose reductase activates hepatic peroxisome proliferator-activated receptor-alpha and ameliorates hepatosteatosis in diabetic db/db mice. Exp Diabetes Res 2012:789730.

9. Zhan YY, Chen Y, Zhang Q, Zhuang JJ, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T, Wu Q (2012) The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat Chem Biol 8:897-904.

10. Zhang T, Luo Y, Wang T, Yang JY* (2012) MicroRNA-297b-5p/3p target Mllt3/Af9 to suppress lymphoma cell proliferation, migration and invasion in vitro and tumor growth in nude mice. Leuk Lymphoma 53:2033-2040.

11. Ahmed MM, Wang T, Luo Y, Ye S, Wu Q, Guo Z, Roebuck BD, Sutter TR, Yang JY* (2011) Aldo-keto reductase-7A protects liver cells and tissues from acetaminophen-induced oxidative stress and hepatotoxicity. Hepatology 54:1322-1332.

12. Huang W, Liu H, Wang T, Zhang T, Kuang J, Luo Y, Chung SS, Yuan L, Yang JY* (2011) Tonicity-responsive microRNAs contribute to the maximal induction of osmoregulatory transcription factor OREBP in response to high-NaCl hypertonicity. Nucleic Acids Res 39:475-485.

13. Liu H, Luo Y, Zhang T, Zhang Y, Wu Q, Yuan L, Chung SS, Oates PJ, Yang JY* (2011) Genetic deficiency of aldose reductase counteracts the development of diabetic nephropathy in C57BL/6 mice. Diabetologia 54:1242-1251.

14. Qiu L, Zhang C, Zhang J, Liang J, Liu J, Ji C, Yang JY* (2009) Intraperitoneal co-administration of thymosin alpha-1 ameliorates streptozotocin-induced pancreatic lesions and diabetes in C57BL/6 mice. Int J Mol Med 23:597-602.

15. Xu J, Zhang J, Cai S, Dong J, Yang JY, Chen Z (2009) Metabonomics studies of intact hepatic and renal cortical tissues from diabetic db/db mice using high-resolution magic-angle spinning 1H NMR spectroscopy. Anal Bioanal Chem 393:1657-1668.

16. Guo ZS, LI Q, Bartlett DL, Yang JY, Fang B (2008) Gene transfer: the challenge of regulated gene expression. Trends Mol Med 14:410-418.

17. Qiu L, Wu X, Chau JF, Szeto IY, Tam WY, Guo Z, Chung SK, Oates PJ, Chung SS*, Yang JY* (2008) Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis. J Biol Chem 283:17175-17183.

18. Yang JY*, Tam WY, Tam S, Guo H, Wu X, Li G, Chau JF, Klein JD, Chung SK, Sands JM, Chung SS* (2006) Genetic restoration of aldose reductase to the collecting tubules restores maturation of the urine concentrating mechanism. Am J Physiol Renal Physiol 291:F186-F195.

19. Wang Y, Ko BC, Yang JY*, Lam TT, Jiang Z, Zhang J, Chung SK, Chung SS* (2005) Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaks. J Biol Chem 280:19986-19991.

20. Lam AKM, Ko BCB, Tam S, Morris R, Yang JY, Chung SK, Chung SSM (2004) Osmotic response element binding protein (OREBP) is an essential regulator of urine concentrating mechanism. J Biol Chem 279:48048-48054.

专著和专利:

1. 杨云青, microRNAs与肾脏应激调控和肾脏相关疾病(研究生教材),《生理科学进展》-第五篇肾脏和泌尿生理学-33章,高等教育出版社,北京,2014

2. 杨云青,张田甜, miR-297b 的用途,中国发明专利,专利号201110403135.9,授权日期2013417

3. 杨云青,蔡建春,纪顺龙,张君,叶耿泰,王霖沛,张田甜,王涛,罗羽,郭宗圣, miR-574-5p的用途,中国发明专利,专利号201110400957.1,授权日期2013417