欧阳高亮教授

文章出处: 作者: 发布时间: 2014-04-18 访问次数: 647

欧阳高亮 OUYANG Gaoliang  Ph.D.

新世纪优秀人才,教授,博士生导师

干细胞与肿瘤转移课题组 组长

Laboratory of Stem Cells and Tumor Metastasis

  话:+86-592-2186091

E-mailoygldz@xmu.edu.cn

教育及工作经历:

1993年毕业于南昌大学生物学系,获学士学位

2001年毕业于厦门大学生命科学学院,获博士学位

2006.2-2008.1在美国加州大学伯克利分校进行访问研究

现为厦门大学生命科学学院教授,博士生导师,副院长

研究领域:

肿瘤转移是一复杂的多步骤过程,涉及肿瘤细胞侵袭转移至靶器官、适应并重塑靶器官的组织微环境。本课题组长期致力于研究基质蛋白(如PeriostinOPN等)在肿瘤转移中的功能,发现这些蛋白可通过促进细胞生存、上皮细胞间质转分化、干细胞干性维持和血管发生来促进肿瘤转移。我们目前的研究表明基质蛋白在炎症发生和肿瘤转移过程中可参与重塑组织微环境。本课题组将继续深入研究基质蛋白在调控干细胞微环境、炎症微环境和肿瘤转移微环境中的功能。

代表性论著:

1. Liu AY, Ouyang G*. Tumor angiogenesis: glioblastoma stem cells as a new source of pericytes. Curr Biol, 2013; DOI: 10.1016/j.cub.2013.05.023. (*Corresponding author).

2. Wang Z, Ouyang G*. Periostin: a bridge between cancer stem cells and their metastatic niche. Cell Stem Cell, 10: 111-112, 2012.

3. Fang X, Cai Y, Liu J, Wang Z, Wu Q, Zhang Z, Yang CJ, Yuan L, Ouyang G*. Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal. Oncogene, 30: 4707-4720, 2011.

4. Ouyang G*, Wang Z, Fang X, Liu J, Yang CJ. Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells. Cell Mol Life Sci, 67: 2605-2618, 2010.

5. Ruan K, Bao S, Ouyang G*. The multifaceted role of periostin in tumorigenesis. Cell Mol Life Sci, 66: 2219-2230, 2009.

6. Song G#, Ouyang G#, Mao Y, Ming Y, Bao S, Hu T. Osteopontin promotes gastric cancer metastasis by augmenting cell survival and invasion through Akt-mediated HIF-1a up-regulation and MMP9 activation. J Cell Mol Med, 13: 1706-1718, 2009. (#These authors contributed equally to this work).

7. Ouyang G*, Liu M, Ruan K, Song G, Mao Y, Bao S. Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway. Cancer Lett, 281: 213-219, 2009.

8. Song G, Cai QF, Mao YB, Ming YL, Bao SD, Ouyang GL*. Osteopontin promotes ovarian cancer progression and cell survival and increases HIF-1α expression through PI3-K/Akt pathway. Cancer Sci, 99: 1901-1907, 2008.

9. Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, Shao R, Anderson RM, Rich JN, Wang XF*. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell, 5: 329-339, 2004.