李博安教授

文章出处: 作者: 发布时间: 2014-04-18 访问次数: 448

李博安Ph.D.

闽江特聘,教授,博士生导师

发育与肿瘤细胞生物学

课题组组长

  话:+86-592-2181987

E-mailbali@xmu.edu.cn

教育及工作经历:

1986年,第四军医大学,医学学士学位;

1996年,上海肿瘤研究所,生物化学与分子生物学博士学位;

19982006年,德国和美国先后任博士后和高级研究员;

20061月至今,厦门大学生命科学学院,闽江学者特聘教授,博士生导师。

2012年至今,厦门大学生命科学学院,副院长。

研究领域:

wnt信号通路在正常组织发育和肿瘤形成过程中发挥重要作用。我们实验室的兴趣在于,研究该信号通路的主要组份与调节因子在正常以及应激条件下,对于肿瘤发生、发展和组织发育、代谢过程的影响;涉及到表观遗传学、干细胞生物学等生物学前沿领域。

代表性论文:

1. Yang M, Li SN, Anjum KM, Gui LX, Zhu SS, Liu J,  Chen JK, Liu QF, Ye GD, Wang WJ, Wu JF, Cai WY, Sun GB, Liu YJ, Liu RF, Zhang ZM and Li BA* . Double-Negative Feedback Loop Between Wnt/β-catenin Signaling and HNF4α Regulates Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma. J Cell Sci. 2013,  Oct 7, doi:10.1242/jcs.135053

2. Cai WY, Wei TZ, Luo QC, Wu QW, Liu QF, Yang M, Ye GD, Wu JF, Chen YY, Sun GB, Liu YJ, Zhao WX, Zhang ZM, Li BA*. Wnt/β-catenin pathway represses let-7 microRNAs expression via transactivation of Lin28 to augment breast cancer stem cell expansion. J Cell Sci. 2013 Apr 23. [Epub ahead of print]

3. Li BA*. A novel tumor suppressor miRNA miR-520e contributes to suppression of hepatoma. Acta Pharmacol Sin. 2012 Jan; 33(1):3-4.

4. Chen HZ, Liu QF, Li L, Wang WJ, Yao LM, Yang M, Liu B, Chen W, Zhan YY, Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA*, Wu Q*. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling . GUT.2012; 61:714-724.

5. Chen J,  Luo Q,  Yuan YHuang X, Cai W,  Li C, Wei T,  Zhang L, YanM, Liu Q, Ye G, Cheng P, Dai and Li B*. Pygo2 associates with MLL2 histone methyltransferase (HMT) and GCN5 histone acetyltransferase (HAT) complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion. Mol. Cell. Biol. 2010 Dec;30(24):5621-35.

6. Chen YY, Li BA*, Wang HD, Liu XY, Tan GW, Ma YH, Shen SH, Zhu HW, Wang ZX. The role of Pygopus 2 in rat glioma cell growth. Med Oncol. 2011 Jun; 28(2):631-40. 

7. Wang ZX, Chen YY, Li BA*, Tan GW, Liu XY, Shen SH, Zhu HW, Wang HD. Decreased pygopus 2 expression suppresses glioblastoma U251 cell growth. J Neurooncol. 2010 Oct;100(1):31-41.

8. Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru K, Millar S, Lee EY, Lewis MT, and  Li B*, Dai X*,  Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol. 2009, 185,811-826.

9. Li B*,  Teng A, Bilanchone V, Munguia JE, Hu M, Jessen S, Piccolo S, Waterman ML, Dai X. Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Genesis.2007 May; 45(5): 318-25

10.  Ye Y, Li B*. 1'S-1'-Acetoxychavicol acetate (ACA) isolated from Alpinia galanga inhibits human immunodeficiency virus type 1 (HIV-1) by blocking Rev transport. Journal of general Virology. 2006; 87: 2047-2053.

11. Li B*., Nair, M., Mackay, DR., Bilanchone, V., Hu, M., Fallahi, M., Song, H., Dai, Q., Cohen, PE., Dai, X. Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development. 2005; 132, 1463-1473.

12. Li B*., Mackay, DR., Ma, J., Dai, X. Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component. Genomics. 2004; 84(2): 398-405.

13.  Li B*., Dai, Q., Li, L., Nair, M., Mackey, D., Dai, X. Ovol2, a Mammalian Homolog of Drosophila ovo: Gene Structure, Chromosomal Mapping, and Aberrant Expression in Blind-Sterile Mice. Genomics. 2002; 80(3):319

14. Li B*., Mackey, DR, Dai, Q., Li, TW., Nair M., Fallahi, M., Schonbaum, CP., Fantes, J., Mahowald, AP., Waterman, ML., Fuchs, E., Dai, X. The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc Natl Acad Sci, U S A. 2002; 30;99(9):6064-9.