林圣彩教授

文章出处: 作者: 发布时间: 2014-04-18 访问次数: 741

林圣彩,Ph.D.

教授博士生导师。教育部“长江学者”特聘教授,科技部重大科学研究计划项目首席科学家,国家杰出青年基金获得者。厦门大学生命科学学院院长。

E-maillinsc@xmu.edu.cn

实验室网址:http://121.192.179.196/linlab/

教育及工作经历:

1984年,厦门大学生物系,学士学位;

1991年,美国德克萨斯大学西南医学中心,生物化学博士;

1991年至1995年,美国Howard Hughes Institute at UCSD博士后;

1995年至2001年,新加坡国立大学分子与细胞生物研究所实验室主任;

2001年至2006年,香港科技大学生化系助理教授、副教授;兼职于厦门大学生命科学学院,任长江学者特聘教师;2003年起初任院长;

2006年至今,厦门大学生命科学学院长江学者、博士生导师。

2013年入选国家百千万工程人才

 

 

研究领域:

研究细胞生长、代谢稳态维持及其调控细胞生长的分子机制。

1)细胞能量平衡分子机制

2)氨基酸合成调控与细胞生长的关系

3)合成与分解代谢的转换机制

4)机体代谢的平衡机制

 

 

代表性论文 (Selected Publications)

1. Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y,  Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, and Lin SC*. Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy. Autophagy, 8(9):1385-6, 2012

2. Guo HL, Zhang C, Liu Q, Li Q, Lian G, Wu D, Li X, Zhang W, Shen Y, Ye Z, Lin SY, Lin SC*. The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation. Cell Res. 22: 1246-57, 2012

3. Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y,  Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, and Lin SC*. GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science 336, 477, 2012

4. Li, Q., He, Y., Wu, X., Wei, L., Lin, S.-Y., Wang, Z., Lin, S.-C*. AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation. Oncogene 30: 1194-1204, 2011.

5. Li, Q., Lin, S.Y., Wang, X., Lian, G., Lu. Z., Guo, H., Ruan, K., Wang, Y., Ye, Z., Han, J., and Lin, S-C*. Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nat. Cell Biol. 11, 1128-1135, 2009.

6. Lu, Z., Liu, W., Huang, H., He, Y., Han, Y., Wang, Y., Li, Q., Ruan, K., Ye, Z., Low, B. C., Meng, A., Lin, S.-C*. Protein encoded by the AxinFu allele effectively downregulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. J. Biol. Chem. 283, 13132-9, 2008.

7. Li, Q., Wang, X., Wu, X., Rui, Y., Liu, W., Wang, J., Wang, X., Liou, Y.-C., Ye, Z., and Lin, S.-C. Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death. Cancer Res., 67, 66-74, 2007.

8. Rui, Y., Xu, Z., Xiong, B., Cao, Y., Lin, S., Chan, S.C., Luo, W., Han, Y., Lu, Z., Ye, Z., Zhou, H.-M., Han, J., Meng, A.*, Lin, S.-C.* A ß-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by Aida. Dev. Cell, 13, 268-282, 2007.

9. Rui,Y.N., Xu, Z., Lin, S.Y., Li, Q.X., Rui, H.L., Luo, W., Zhou, H.M., Cheung, P.Y., Wu, Z.G., Ye, Z.Y., Li, P., Han, J.H., and Lin, S.-C.*  Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 23, 4583-4594, 2004 

10. Rui,Y.N., Xu, Z., Lin, S.Y., Li, Q.X., Rui, H.L., Luo, W., Zhou, H.M., Cheung, P.Y., Wu, Z.G., Ye, Z.Y., Li, P., Han, J.H., and Lin, S.-C.*  Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J. 23, 4583-4594, 2004